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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 331 (1985), S. 20-22 
    Details
    ISSN: 1432-1912
    Keywords: Desipramine ; p-Chlorophenylalanine ; Locomotion ; Rat ; Beta receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The decrease in the B max value of 3H-dihydroalprenolol (3H-DHA) binding to cortical membranes of rat brain induced by long-term administration of desipramine (DMI) was prevented by concomitant treatment with parachlorophenylalanine (pCPA). Acute administration of DMI significantly decreased locomotor activity in saline- and (pCPA)-pretreated rats. DMI-induced inhibition of locomotor activity was abolished in (pCPA)-pretreated rats chronically treated with DMI. Conversely, in pCPA-pretreated animals, acute DMI could still significantly decrease the locomotion of chronically DMI-treated rats. The data presented indicated that an intact serotoninergic system is required to enable antidepressant drugs to induce biochemical and behavioral changes following their chronic administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498847
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioural and biochemical effects in the adult rat after prolonged postnatal administration of clozapine (1983)
    Springer
    Psychopharmacology 81 (1983), S. 239-243 
    Details
    ISSN: 1432-2072
    Keywords: Postnatal treatment ; Clozapine ; Apomorphine ; Stereotyped behaviour ; Locomotion ; Learning ; HVA ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were administered 10 mg/kg SC of clozapine (C) or vehicle solution (S) daily from day 1 after birth until 20 days of age. At 60 days of age (40 days after the postnatal treatment with C or S was interrupted) the stereotyped behaviour and the effects on locomotor activity elicited by apomorphine in S-and C-pretreated rats were investigated. The intensity of stereotyped behaviour as well as the decrement in locomotion induced by apomorphine (0.5–1 mg/kg SC) were not influenced by chronic C administration during development. Finally, at 80 days of age (60 days after the postnatal treatment with C or S was interrupted) rats were subjected to a differential reinforcement of low rates schedule (DRL15s). The results indicate that the acquisition of the DRL task performance criterion (Rs/Rf≤2.5) was significantly more rapid in S-pretreated rats than in C-pretreated ones. In parallel biochemical experiments, homovanillic acid (HVA) content was measured in striatum in rats at 60 days of age (40 days after the postnatal treatment with C or S was interrupted). The results indicate that even if an acute challenge dose of 10 mg/kg C shows a certain degree of tolerance a single dose of 20 mg/kg C is still able to increase striatal HVA concentration in chronic C-pretreated animals. These data indicate that early postnatal administration of a non-cataleptogenic neuroleptic, like C, induces, in the adult rat, behavioural and biochemical changes which significantly differ from those elicited by a cataleptogenic neuroleptic, like haloperidol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427270
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  • 3
    Electronic Resource
    Electronic Resource
    Enduring behavioural and biochemical effects in the adult rat after prolonged postnatal administration of haloperidol (1981)
    Springer
    Psychopharmacology 74 (1981), S. 166-169 
    Details
    ISSN: 1432-2072
    Keywords: Postnatal treatment ; Haloperidol ; Apomorphine ; Stereotyped behaviour ; Locomotion ; Learning ; DOPAC ; HVA ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were administered 0.5 mg/kg SC of haloperidol (H) or saline (S) daily from day 1 after birth until 20 days of age. At 60 days of age (40 days after the postnatal treatment with H or S was interrupted) the stereotyped behaviour and the effects on locomotor activity elicited by apomorphine in S- and H-pretreated rats were investigated. The intensity of apomorphine (0.5–1 mg/kg, SC)-induced stereotyped behaviour was significantly greater in the H-pretreated group than in S-pretreated animals and this was accompanied by a much more marked reduction of locomotor activity in H-pretreated than in S-pretreated rats. Finally, at 80 days of age (60 days after the postnatal treatment with H or S was interrupted) rats were subjected to a Differential Reinforcement of Low Rates schedule (DRL 15-s). The results indicate that the acquisition of the DRL task performance criterion (Rs/Rf≤2.5) was significantly more rapid in S-pretreated rats than in H-pretreated ones. In parallel biochemical experiments, acute H produced smaller increases in dopamine turnover in chronic H-treated rats compared with S-treated controls. These data indicate that H treatment in neonatal rats induces behavioural and biochemical changes which can be observed up to 60 days after H withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432686
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  • 4
    Electronic Resource
    Electronic Resource
    Early postnatal chlordiazepoxide administration: Permanent behavioural effects in the mature rat and possible involvement of the GABA-benzodiazepine system (1983)
    Springer
    Psychopharmacology 81 (1983), S. 261-266 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Postnatal treatment ; Long term behavioural and biochemical effects ; GABA-benzodiazepine receptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The long term behavioural and biochemical effects of chronic chlordiazepoxide treatment during the period of neuronal maturation in the rat have been investigated. The administration to lactating mothers of chlordiazepoxide at very low doses (0.22 and 2.6 mg/kg) in their drinking water affects both behavioural and biochemical parameters in offspring at 60 days of age and undrugged since weaning. A deficit in the acquisition of the conditioned avoidance response in treated rats was observed, although no significant difference in spontaneous locomotor activity between control and treated rats was found. 3H-Flunitrazepam binding sites in cerebral cortex and hippocampus were decreased by the treatment, whereas no change was detected in cerebellum. Moreover, 3H-muscimol binding sites increased in hippocampus with no changes in cerebral cortex and cerebellum. According to the different regional distribution of benzodiazepine type 1 and type 2 receptors, we suggest that type 2 receptors are selectively affected by the treatment, and that the GABA ergic receptor system is also permanently altered by administration of chlordiazepoxide during early postnatal life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427275
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  • 5
    Electronic Resource
    Electronic Resource
    Behavioural responsiveness to muscimol and apomorphine 2 months after prolonged treatment with estradiol in rats (1984)
    Springer
    Psychopharmacology 84 (1984), S. 287-288 
    Details
    ISSN: 1432-2072
    Keywords: Prolonged estradiol treatment ; Behaviour ; Rat ; Muscimol ; Apomorphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two months after prolonged administration of estradiol (ES) in female rats the behavioural responsiveness to muscimol, a GABA receptor stimulating agent, and to apomorphine, a dopamine receptor agonist, was significantly altered. In particular, the decrease in locomotor activity induced by a challenge dose of muscimol (0.5–1 mg/kg) was significantly attenuated in ES-pretreated animals. Conversely, the intensity of stereotyped behaviour elicited by a challenge dose of apomorphine (1 mg/kg) was significantly increased in ES-pretreated rats. The behavioural alterations in the response to muscimol and apomorphine presumably result from the production of central GABA receptor subsensitivity and dopamine receptor supersensitivity respectively, induced by the prolonged ES administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427462
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  • 6
    Electronic Resource
    Electronic Resource
    Irreversible impairment of active avoidance behavior in rats prenatally exposed to mild concentrations of carbon monoxide (1995)
    Springer
    Psychopharmacology 122 (1995), S. 66-71 
    Details
    ISSN: 1432-2072
    Keywords: Carbon monoxide ; Prenatal exposure ; Behavior ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wistar female rats were exposed to relatively mild concentrations of carbon monoxide (75 and 150 ppm) from day 0 to day 20 of pregnancy. The results show that prenatal exposure to CO (150 ppm) significantly impairs the acquisition of a two-way active avoidance task in 3-month-old male rats as well as the acquisition and reacquisition of this schedule in 18-month-old animals subjected to six daily 20-trial sessions. These deficits do not seem to be attributable to alterations of a non-associative nature, as the intertrial activity and the escape response latencies in CO exposed animals were not significantly affected with respect to controls. These findings, showing that gestational exposure to CO induces in rat offspring permanent learning and memory impairment, confirm that the offspring of smoking mothers may be at considerably greater risk than current epidemiological studies on birthweight and neonatal mortality suggest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246443
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  • 7
    Electronic Resource
    Electronic Resource
    Valutazione dei dati aerosporologici ottenuti in due diverse stazioni di rilevamento di una stessa città (1987)
    Springer
    Aerobiologia 3 (1987), S. 73-77 
    Details
    ISSN: 1573-3025
    Keywords: Aerobiological data ; Mould allergy ; Dati aerobiologici ; Allergia da miceti
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Summary Mould spores at two different places in Cagliari from February to April 1987 have been studied using Petri dishes containing “Potato dextrose agar”. The change of the numerical consistence of the isolations in two different places has been observed. 6702 mycetical colonies, belonging to 15 different genera, have been isolated; 6 of them mostly prevailing. On the basis of the amount and variety of isolated species, the Authors think that mould air-spores are not a negligible risk factor allergic disease.
    Notes: Riassunto Nel presente lavoro vengono riportati gli studi quantitativi e qualitativi delle spore micetiche presenti in due diverse zone della città di Cagliari. I rilevamenti sono stati effettuati nei mesi di Febbraio, Marzo ed Aprile del 1987 utilizzando capsule di Petri contenenti “Potato dextrose agar” più antibiotico. Sono state osservate differenze significative nella frequenza delle spore delle due zone considerate. Nel corso dell'intera ricerca abbiamo isolato 6702 colonie filamentose appartenenti a 15 generi diversi; 6 generi sono stati repertati costantemente. Sulla base della quantità e varietà delle specie micetiche identificate, gli Autori ritengono che le spore aerodiffuse possono costituire un fattore di rischio non trascurabile.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02449997
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