ISSN:
1432-2072
Keywords:
Prolonged estradiol treatment
;
Behaviour
;
Rat
;
Muscimol
;
Apomorphine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two months after prolonged administration of estradiol (ES) in female rats the behavioural responsiveness to muscimol, a GABA receptor stimulating agent, and to apomorphine, a dopamine receptor agonist, was significantly altered. In particular, the decrease in locomotor activity induced by a challenge dose of muscimol (0.5–1 mg/kg) was significantly attenuated in ES-pretreated animals. Conversely, the intensity of stereotyped behaviour elicited by a challenge dose of apomorphine (1 mg/kg) was significantly increased in ES-pretreated rats. The behavioural alterations in the response to muscimol and apomorphine presumably result from the production of central GABA receptor subsensitivity and dopamine receptor supersensitivity respectively, induced by the prolonged ES administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427462
