Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
5 (1976), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Lymphocytes from the peripheral blood, spleen, or para-aortic lymph nodes of primigravida L rats carrying (L × BN)F1 (LBN) fetuses are fully capable of mounting graft-versus-host (GVH) reactions in LBN F1 recipients. The reactivity of lymphocytes from interstrain pregnant (L × BN) or intrastrain pregnant (L × L) rats, or from rats postpartum from these pregnancies, is equivalent to that of normal virgin females over a full dose-response curve, ruling out both specific and nonspecific effects of pregnancy on the intrinsic GVH competence of the maternal thymus-derived (T) lymphocyte. Attempts to block GVH reactivity with serum from pregnant rats were unsuccessful. In addition, when the distribution pattern of 51Cr-labeled syngeneic and semiallogeneic lymphocytes was studied in intact primigravida mice, there was no difference between inter-strain and intrastrain pregnant mice, and there was no evidence of immunologically specific ‘trapping’ in the para-aortic lymph nodes draining the interstrain pregnant uterus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1976.tb00310.x
Permalink
Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |