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  • 1
    Electronic Resource
    Electronic Resource
    Relating zircon and monazite domains to garnet growth zones: age and duration of granulite facies metamorphism in the Val Malenco lower crust (2003)
    Oxford, UK : Blackwell Science Inc
    Journal of metamorphic geology 21 (2003), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Zircon from a lower crustal metapelitic granulite (Val Malenco, N-Italy) display inherited cores, and three metamorphic overgrowths with ages of 281 ± 2, 269 ± 3 and 258 ± 4 Ma. Using mineral inclusions in zircon and garnet and their rare earth element characteristics it is possible to relate the ages to distinct stages of granulite facies metamorphism. The first zircon overgrowth formed during prograde fluid-absent partial melting of muscovite and biotite apparently caused by the intrusion of a Permian gabbro complex. The second metamorphic zircon grew after formation of peak garnet, during cooling from 850 °C to c. 700 °C. It crystallized from partial melts that were depleted in heavy rare earth elements because of previous, extensive garnet crystallization. A second stage of partial melting is documented in new growth of garnet and produced the third metamorphic zircon. The ages obtained indicate that the granulite facies metamorphism lasted for about 20 Myr and was related to two phases of partial melting producing strongly restitic metapelites.Monazite records three metamorphic stages at 279 ± 5, 270 ± 5 and 257 ± 4 Ma, indicating that formation ages can be obtained in monazite that underwent even granulite facies conditions. However, monazite displays less clear relationships between growth zones and mineral inclusions than zircon, hampering the correlation of age to metamorphism. To overcome this problem garnet–monazite trace element partitioning was determined for the first time, which can be used in future studies to relate monazite formation to garnet growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1314.2003.00484.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of aliphatic alcohols on growth and degree of saturation of membrane lipids in Acinetobacter calcoaceticus (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 220 (2003), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The adaptive responses of the bacterium Acinetobacter calcoaceticus to different aliphatic alcohols on the level of the membrane fatty acids were studied in detail. The toxicity of the aliphatic alcohols increased with an increasing hydrophobicity. As alcohols are known to increase the fluidity of the membrane they consequently should cause the same adaptive effect on membrane level. Yet, cells of A. calcoaceticus react completely different to the alcohols: in the presence of long-chained alcohols they increase their degree of saturation, while in the presence of short-chained alcohols they decrease the degree of saturation. So, there are no observable differences in the adaptive responses of bacteria with the so-called anaerobic pathway, like Escherichia coli and Pseudomonas putida, and the bacterium carrying the so-called aerobic pathway like A. calcoaceticus. These results strongly indicate a physico-chemical difference in the membrane effect of both the partitioning and localisation of the different alcohols into the membrane and the membrane adaptive responses of the bacteria to these effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0378-1097(03)00103-4
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  • 3
    Electronic Resource
    Electronic Resource
    Ultraviolet B 308-nm excimer laser treatment of psoriasis: a new phototherapeutic approach (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Excimer laser-derived 308-nm ultraviolet (UV) B therapy is a new alternative for treating psoriasis by phototherapy. Some studies have been made showing the effectiveness of intralesional phototherapy technology in treating psoriasis. However, there has been no information available so far with regard to the cumulative dosage on a larger group of patients and on therapy optimized treatment strategies.Objectives  One hundred and twenty psoriatic patients were treated according to standard protocol to define the effectiveness. Our aim was to develop new parameters and determine whether effectiveness could be improved and whether treatment exposure, the cumulative UVB dose and adverse effects could be minimized.Methods  Initially, the excimer laser's effectiveness in treating psoriasis was evaluated in an open prospective study according to standard protocol. This included 120 adult patients (67 female/53 male) with chronic plaque psoriasis and 〈 20% involved body surface. The initial dose was based on three multiples of a predetermined minimal erythema dose (MED). Patients were treated twice a week for the first 3 weeks, then once a week until clearance was achieved. The main parameters were the initial starting dose, psoriasis area and severity index (PASI), the number of treatments needed, the time in treatment and the cumulative dose needed to clear psoriatic plaques. Thereafter, 43 patients were treated as a second comparable group. Therapy began with a starter dose, defined as MED-I. MED-I was defined as a UVB 308-nm dose which provoked a visible increase in erythema after 24 h. In addition, the epidermal thickness of the plaques was measured on an individual basis by 20-MHz ultrasound and correlated to the MED-I.Results  Of the patients who met the standard protocol, 65·7% were at least 90% clear after a maximum of 10 treatments; an even greater number (85·3%) showed a ≥ 90% improvement in PASI after 13 sessions, while 14·7% of patients had only a ≤ 50% PASI improvement. The cumulative UVB dose was 11·25 ± 4·21 J cm−2 and the average treatment time was 7·2 weeks. Patients treated individually with the MED-I starter dose showed nearly identical rates of clearance (83·7%), but were clear in 7·07 ± 2·15 sessions with a cumulative dose of 6·25 ± 4·02 J cm−2.Conclusions  The majority of our patients benefited greatly from laser-derived 308-nm UVB therapy, which cleared skin lesions faster than conventional phototherapy. As this therapy targets only the involved skin, the thickness of the plaques and individual MED-I should determine the initial dose, thus increasing the effectiveness of the therapy. We propose that light therapy sparing uninvolved skin will become predominant in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2003.05709.x
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  • 4
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    Unknown
    Wandrers Sturmlied--Neidgetroffen. (1946)
    Washington, etc. : Periodicals Archive Online (PAO)
    Germanic Review. 21:3 (1946:Oct.) 165 
    Details
    ISSN: 0016-8890
    Topics: German, Dutch and Scandinavian Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1091-1946-003-00-000002
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  • 5
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    Die tote Maus oder Nachtrag zur 'moralischen Verwirrung der Zeit.' Schillers Urenkel in Thomas Manns "Doktor Faustus" (1984)
    Stuttgart, etc. : Periodicals Archive Online (PAO)
    Deutsche Vierteljahrsschrift für Literaturwissenschaft und Geistesgeschichte. 58:3 (1984:Sept.) 470 
    Details
    ISSN: 0012-0936
    Topics: German, Dutch and Scandinavian Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0088-1984-058-03-000007
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  • 6
    Electronic Resource
    Electronic Resource
    The cis–trans isomerase of unsaturated fatty acids in Pseudomonas and Vibrio: biochemistry, molecular biology and physiological function of a unique stress adaptive mechanism (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 229 (2003), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Isomerization of cis to trans unsaturated fatty acids is a mechanism enabling Gram-negative bacteria belonging to the genera Pseudomonas and Vibrio to adapt to several forms of environmental stress. The extent of the isomerization apparently correlates with the fluidity effects caused, i.e. by an increase in temperature or the accumulation of membrane-toxic organic compounds. Trans fatty acids are generated by direct isomerization of the respective cis configuration of the double bond without a shift of its position. The conversion of cis unsaturated fatty acids to trans is apparently instrumental in the adaptation of membrane fluidity to changing chemical or physical parameters of the cellular environment. Such an adaptive mechanism appears to be an alternative way to regulate membrane fluidity when growth is inhibited, e.g. by high concentrations of toxic substances. The cis–trans isomerase (Cti) activity is constitutively present and is located in the periplasma, it requires neither ATP nor any other cofactor such as NAD(P)H or glutathione, and it operates in the absence of de novo synthesis of lipids. Its independence from ATP is in agreement with the negative free energy of the reaction. cti encodes a polypeptide with an N-terminal hydrophobic signal sequence, which is cleaved off during or shortly after the enzyme is transported across the cytoplasmic membrane to the periplasmic space. A functional heme-binding site of the cytochrome c-type was identified in the predicted Cti polypeptide and very recently, direct evidence was obtained that isomerization does not include a transient saturation of the double bond.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0378-1097(03)00792-4
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of glutathione S-transferase and peptide methionine sulphoxide reductase in Ochrobactrum anthropi is correlated to the production of reactive oxygen species caused by aromatic substrates (2004)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 241 (2004), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Peptide methionine sulphoxide reductase (MsrA) and glutathione S-transferases (GSTs) are considered as detoxification enzymes. In the xenobiotics-degrading bacterium Ochrobactrum anthropi the two enzymes are co-induced by toxic concentrations of aromatic substrates such as phenol and 4-chlorophenol. In aerobic organisms, degradation of aromatic substrates by mono- and dioxygenases leads to a generation of oxidative stress that causes the occurrence of reactive oxygen species (ROS). A capillary electrophoretic method, using the intracellular conversion of dihydrorhodamine-123 into rhodamine-123, was developed to measure the content of ROS in the bacteria. The presence of toxic concentrations of the aromatic substrate 4-chlorophenol, an inducer of GST and MsrA, leads to a significant increase in the production of ROS. These results strongly suggest that GST and MsrA enzymes are part of the bacterial defence mechanism against particular oxidative stress conditions. As oxidative stress is known to be present predominantly close to the cytoplasmic membrane, we investigated the subcellular distribution of both MsrA and GST enzymes in this bacterium grown in the presence of 4-chlorophenol. By Western blotting, MsrA and GST was assayed in the cytoplasm as well as in the periplasm. Moreover, immunolocalisation by colloidal gold immunoelectron microscopy identified the two proteins associated with the cell envelope.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsle.2004.10.013
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  • 8
    Electronic Resource
    Electronic Resource
    Struktur und Farbigkeit von P,P′-Tetra-t-butyl-und P, P′-Tetraphenyl-oxalsäurediphosphid und Derivaten (1980)
    Springer
    Monatshefte für Chemie 111 (1980), S. 749-759 
    Details
    ISSN: 1434-4475
    Keywords: Crystal structure ; Electronic transitions and structure ; Oxalic acid phosphides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The unexpected violet colour of P,P′-tetraphenyl-oxalic acid diphosphide (3) stimulated the synthesis of the following derivatives: P,P′-tetra-t-butyl-oxalic acid diphosphide (2), N,P-tetraphenyl-oxalic acid amide phosphide (4) and P, α-triphenyl-glyoxylic acid phosphide (5). The compounds could be prepared by the reaction of the corresponding acyl chlorides with diorganyl-(trimethylsilyl) phosphine; (organyl=t-butyl and phenyl). The electronic transitions of green-blue2 and red5 in the 450–700 nm region are discussed, also theirv C=O in the ir spectrum. These results are interpreted in connection with the molecule structures of2 and3 which have been determined by X-ray crystal structure analysis. In2 the framework P−C(O)−C(O)−P is only slightly distorted from a coplanartrans-position, in3 somewhat more. The bonds at P have the expected pyramidal arrangement. The direction of the lone pairs at the P-atoms, derived from this bond arrangement, is discussed with respect to the electronic transitions in acyl phosphides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00903328
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  • 9
    Electronic Resource
    Electronic Resource
    Diphenylarsinoderivate des Maleinsäureanhydrids und verwandte Verbindungen. Kristall- und Molekülstruktur des 2,3-Bis(diphenylstibino)maleinsäureanhydrids (1980)
    Springer
    Monatshefte für Chemie 111 (1980), S. 177-191 
    Details
    ISSN: 1434-4475
    Keywords: Bis(diphenylarsino)maleic acid, derivatives ; Bis(diphenylstibino)maleic anhydride, synthesis, crystal structure ; Bis(phenylthio)maleic acid, derivatives ; Maleic acid derivatives, synthesis, molecular structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The unusual properties of bis(diphenylphosphino)maleic anhydride and similar ditertiary phosphines has prompted the synthesis of analogous arsines and stibines. Bis(diphenylarsino)maleic anhydride,-maleic thioanhydride and-N-methyl maleic imide, bis(diphenylstibino)maleic anhydride (5) and-maleic thioanhydride are obtained as crystalline yellow or red compounds by the reaction of the corresponding 2,3-dichloromaleic acid derivatives with diphenyl(trimethylsilyl)arsine and-stibine resp. The uv/vis spectra and characteristic i.r. bands of selected compounds are given and compared with those of the corresponding phosphines. The strong shift of νC=C to lower wavenumbers observed in all compounds has caused the determination of crystal and molecular structure of5 by x-ray diffraction. Bond distances and angles are given. The complex formation of the new diarsine ligands has been examined by the preparation of Ni-, Cr- and Mo-carbonyl derivatives. As the first organylsulfane substituted maleic acid derivatives bis(phenylthio)maleic thioanhydride,-N-methyl-maleic imide and-maleic acid dimethylester are synthesized and described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00938726
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  • 10
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    Unknown
    Swift's GULLIVER'S TRAVELS, I.ii (1983)
    Washington, etc. : Periodicals Archive Online (PAO)
    Explicator. 42:1 (1983:Fall) 18 
    Details
    ISSN: 0014-4940
    Topics: Linguistics and Literary Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1084-1983-042-01-000012
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