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  • 11
    Electronic Resource
    Electronic Resource
    Alterations of extracellular matrix induced by tobacco smoke extract (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 188-194 
    Details
    ISSN: 1432-069X
    Keywords: Key words Matrix metalloproteinase ; Extracellular ¶matrix ; Reactive oxygen species
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Epidemiologic studies have indicated the association between tobacco smoking and skin aging, but the exact mechanism of tobacco smoke-induced premature skin aging is currently unknown. In this study, we investigated the alterations of collagen, matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in human fibroblasts treated with tobacco smoke extract. Human fibroblasts were exposed to different concentrations of water-soluble extract from tobacco smoke. Human fibroblasts irradiated with ultraviolet A1 (UVA1) were used as positive controls because the mechanism of UVA1-mediated MMP expression has been well characterized. The expression of MMP and TIMP was analyzed semiquantitatively following reverse transcriptase-polymerase chain reaction. Production of type I and type III collagens was detected by Western blotting and biosynthesis of new collagen was assessed by 3H-proline incorporation. Upon treatment with tobacco smoke extract or UVA1 irradiation, the expression of MMP-1 and MMP-3 mRNA was significantly increased in a dose-dependent manner. Maximum induction was observed with 25 μl/ml tobacco smoke extract. In contrast, the expression of TIMP-1 and TIMP-3 mRNA remained unchanged. Western blotting of the supernatant revealed that type I and type III collagens were decreased as compared with untreated controls. Collagen biosynthesis was significantly reduced by 40.1% following treatment with ¶25 μl/ml tobacco smoke extract. Sodium azide, l-ascorbic acid and Trolox (a water-soluble vitamin E) prevented both the UVA1- and the tobacco-induced alteration of MMP-1. These observations suggest that the imbalance of connective tissue matrix components might contribute to the molecular basis for premature skin aging in smokers. They also suggest that reactive oxygen species including singlet oxygen mediate this process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050476
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  • 12
    Electronic Resource
    Electronic Resource
    Intracranial adenoid cystic carcinoma a case report (1983)
    Springer
    Acta neurochirurgica 69 (1983), S. 291-295 
    Details
    ISSN: 0942-0940
    Keywords: Computer tomography ; adenoid cystic carcinoma ; brain metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A rare case of operatively verified intracranial adenoid cystic carcinoma is reported. In this case, haematogeneous metastasis to the brain parenchyma was suspected. The computer tomography showed a large hypodense mass in the left frontal lobe. The lateral wall of the tumour was irregularly enhanced with contrast media.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401816
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  • 13
    Electronic Resource
    Electronic Resource
    Histochemical studies on the regeneration of aminergic nerves in rat cerebral artery after superior cervical ganglionectomy (1983)
    Springer
    Histochemistry and cell biology 77 (1983), S. 57-62 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The course of regeneration of aminergic nerves in rat cerebral arteries was studied by means of histochemical methods, after uni- or bilateral cervical sympathectomy. Degeneration of aminergic nerves started on day 1 and was complete between days 3 and 7 after surgery. Between weeks 4 and 6, regenerating nerves started to appear from the proximal internal carotid artery. Regenerated aminergic nerve fibres were generally unbeaded and intensity of fluorescence was weak. The circular nerves appeared earlier than the longitudinal ones. The number of regenerating nerves reached the maximum, between months 9 and 12, at about half the normal level. AChE activity of the cerebral arteries showed no significant changes at any stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496636
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  • 14
    Electronic Resource
    Electronic Resource
    MD simulation of atom-order void formation in Ni fcc metal (2000)
    Springer
    Computational mechanics 26 (2000), S. 281-287 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Atom-order void formation in a defective crystalline material is studied by using molecular dynamics method (MD). Infinite long cylinder, which is constructed with nickel atoms with a line of vacancies, is subjected to multiaxial tensile strain field by moving periodic boundary and the atoms on the outer surface of the cylinder. When the load exceeds a critical value, sudden appearance of the void is observed and it develops rapidly. The developed void does not disappear by only unloading and relaxation, in spite of the system with the void has higher potential energy than that without void. The biaxial or the triaxial load is necessary to the atom order void formation. Moreover, the results by the MD simulations are compared with theoretical solution for nonlinear elastic solid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004660000155
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  • 15
    Electronic Resource
    Electronic Resource
    Raman spectroscopic study of Streptomyces subtilisin inhibitor (1982)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 13 (1982), S. 276-279 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Raman spectra of Streptomyces subtilisin inhibitor (SSI) in H2O and D2O solutions were observed for the first time. Information obtained regarding the conformations of polypeptide backbone, disulphide bridge and methionyl side chain was largely consistent with the results derived from other methods. As for the microenvironments of the three tyrosyl residues, the Raman spectrum suggested that none of these residues were involved in a specific interresidue interaction as proposed by nuclear magnetic resonance study for Tyr-93. The Raman spectrum was shown to be useful for studying the binding of the sulphate ion to SSI.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250130313
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