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  • 2000-2004  (2)
  • 1980-1984  (1)
  • 1
    Electronic Resource
    Electronic Resource
    023
The Use of Cilostazol in the Treatment of Raynaulds Disease with Digital Ischemia and Tissue Loss (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Wound repair and regeneration 12 (2004), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: More than three quarters of patients with a connective tissue disorder will develop secondary Raynauld’s disease. This more severe form of the Raynauld’s can lead to digital ischemia, tissue loss and may even result in the need for amputation of one or more digits. Cilostazol is a phosphodiesterase inhibitor currently approved for use in vascular disease of the lower extremities. Case History: In August of 2002 a 62 year old female pianist with scleroderma presented to the wound clinic with a two year history of intractable digital pain secondary to ischemic ulcerations of the index, long and ring fingers of the right hand. She suffered from secondary Raynauld’s disease. Prior unsuccessful treatments included warming the hands, calcium channel blockade, anticoagulation, topical xylocaine and narcotic analgesics. In August of 2002 cilostazol was started at 100mg BID. Wound care consisted of serial debridement, moist wound healing and topical rhPDGF. Results: Four weeks into treatment the patient’s narcotic requirement decreased substantially and the fingers had a pink appearance. The ring finger healed after eight weeks. At three months the patient discontinued narcotic pain medication. Nine months into treatment the index finger had healed and she resumed playing the piano. The long finger finally healed one year after she initially presented to the wound clinic. Conclusion: Cilostazol may be an important adjunct in the treatment of secondary Raynauld’s disease particularly when digital ischemia has developed. Acknowledgements: Funding from Otsuka Pharmaceuticals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2004.0abstractx.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dissolved silica in the Garonne River waters: changes in the weathering dynamics (2000)
    Springer
    Environmental geology 40 (2000), S. 19-26 
    Details
    ISSN: 1432-0495
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  The major ion chemistry of the Garonne River is indicative of seasonal variations in the weathering dynamics of the drainage basin. Using the geochemical model MEGA for calculation of the contribution of atmospheric CO2 to the total bicarbonate fluxes exported by the Garonne River allows estimations of the concentrations of the major dissolved elements that originate from silicate- and carbonate-rock weathering. The molecular ratio SiO2/Al2O3 was calculated for the 1989–1992 period to identify the main type of weathering in the Garonne River, and montmorillonite was shown to be the major mineral occurring in the weathering products. The seasonal variations of the SiO2/Al2O3 ratio also showed that removal of silica was accelerated during humid periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540000119
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    63. Begutachtung von Verletzungen im Bereich des Fußes (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 449-451 
    Details
    ISSN: 1435-2451
    Keywords: Medical opinion ; Injuries of the foot ; Disability ; Undiagnosed lesions ; Begutachtung ; Fußverletzungen ; Invaliditätsgrad ; übersehene Fußverletzungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Siebentel aller Frakturen betrifft den Fuß ohne Knöchel. Jedoch beeinträchtigen auch die Verletzungen des Unterschenkels und Kniegelenkes mittelbar den Fuß. Etwa /13 der Fußverletzungen führt zu einer Gebrauchsbeeinträchtigung von 30% und mehr. Einige Verletzungen (der Bänder, des Gelenkknorpels, Teilverrenkungen des Talus und Kalkaneus, Brüche und Verrenkungen der Keilbeine I und II sowie der Mittelfußknochen I bis III, ferner Fremdkörpereinsprengungen) werden häufig übersehen. Wichtig für die Begutachtung sind Vorgeschichte, Klagen des Patienten, objektiver Befund und Funktionszustand. Röntgenaufnahmen in 2 oder 3 Richtungen sowie Schichtaufnahmen sind differentialdiagnostisch unentbehrlich. Rechtskenntnisse sind unerläßliche Voraussetzung.
    Notes: Summary One-seventh of all fractures concerns the foot, excluding the malleolus, and injuries of the lower leg and knee are also followed by disturbances in the foot. One-third of the foot injuries lead to a 30% disability. Some of the lesions are often undiagnosed (ligaments, articular cartilage, subtotal luxations of the talus or calcaneus, fractures and luxations of the cuneiform bones I and 11 and tarsal bones I–III, additional foreign bodies in the metatarsus). For expert opinion anamnesis, complaints, objective findings, and functional state are important. X-ray pictures in two or three directions or tomograms are needed for differential diagnosis. Knowledge of the laws and of jurisdiction is required to form an opinion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286888
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    Paper (German National Licenses)
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