ISSN:
1433-0350
Keywords:
Key words Acoustic schwannoma
;
MIB-1 staining index
;
Pediatric patient
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Acoustic schwannoma is a slow-growing tumor and usually occurs in adult patients. We report a rare pediatric case of acoustic schwannoma with high proliferative potential. A 10-year-old boy was diagnosed as having a right cerebellopontine angle tumor. The tumor was subtotally resected. Histological examination revealed a typical acoustic schwannoma with a few mitotic figures. Chromosomal analysis showed no abnormality on the long arm of chromosome 22 associated with neurofibromatosis type 2. The lesion regrew rapidly as an acoustic schwannoma, necessitating subtotal resection on three occasions and CyberKnife radiosurgery. The immunohistochemical MIB-1 staining indices of the specimens obtained at the first, second, and third operations were 2.3%, 4.6% and 14.7%, respectively. The immunohistochemical proliferative potential of acoustic schwannoma is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003810050479
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