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  • 1
    Electronic Resource
    Electronic Resource
    Experimental Helicobacter felis Infection in Transgenic Mice Expressing Human Group IIA Phospholipase A2 (2004)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 9 (2004), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background.  Both various virulence factors of Helicobacter pylori and host factors influence the clinical outcome of H. pylori infection. In animal experiments with Helicobacter felis, large variations in the severity of disease have been observed between different mouse strains infected with a single isolate of H. felis. C57BL/6 J mouse strain that lacks the expression of group IIA phospholipase A2 has been shown to develop more severe gastric inflammation than other mouse strains. Thus, group IIA phospholipase A2 has been suggested to play a role in regulating inflammation in gastric mucosa. The aim of this study was to examine the possible role of group IIA phospholipase A2 in experimental Helicobacter infection.Materials and Methods.  Transgenic mice expressing human group IIA phospholipase A2 and their group IIA phospholipase A2 deficient nontransgenic C57BL/6 J littermates were infected with H. felis. The mice were killed 3, 8, and 19 weeks after inoculation of bacteria to determine the histopathological changes in gastric mucosa.Results.  The infected mice developed chronic inflammation in gastric mucosa. We found no differences in the colonization of bacteria between transgenic and nontransgenic mice. At 3 and 8 weeks, no difference was found in the severity of inflammation between the two groups. Nineteen weeks after the administration of bacteria the inflammation was more marked in nontransgenic than transgenic mice. Group IIA phospholipase A2 was expressed by in situ hybridization in the neck cells of the glandular stomach in transgenic mice.Conclusions.  The results of the present study suggest that the endogenous expression of group IIA phospholipase A2 diminishes chronic inflammation in gastric mucosa in experimental H. felis infection in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1083-4389.2004.00257.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of gastric leiomyosarcoma (1978)
    Springer
    Virchows Archiv 379 (1978), S. 25-33 
    Details
    ISSN: 1432-2307
    Keywords: Electron microscopy ; Microfilaments ; Microtubules ; Nuclear pockets ; Smooth muscle tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Samples of gastric leiomyosarcomas from two male patients (69 years and 57 years of age) were studied by electron microscopy. The tumour cells contained abundant 50–90 å thick microfilaments and microtubules. Another cell type, regarded as immature leiomyosarcoma cell, contained numerous profiles of granular endoplasmic reticulum, free ribosomes and a well developed Golgi apparatus. There were intercellular junctions of zonula adherens-type between adjacent tumour cells. It was concluded that electron microscopy offers a valuable aid in the diagnosis of gastric neoplasms of smooth muscle origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432780
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of primary lymphosarcoma of testis (1975)
    Springer
    Journal of cancer research and clinical oncology 84 (1975), S. 189-192 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Fall eines primären Lymphosarkoms im Testis wurde licht- und elektronenmikroskopisch untersucht. Die Feinstruktur der Tumorzellen ist monoton. Das spärliche Cytoplasma enthält normale Zellorganellen. Freie Ribosomen sind zahlreich und der Golgi-Apparat ist gut entwickelt. Die Kerne sind groß und unregelmäßig, die Nukleolen prominent. Einige Kerne enthalten “nuclear pockets” mit Material, das der cytoplasmatischen Grundsubstanz ähnlich ist. Reste degenerierender Zelle werden ebenfalls gefunden.
    Notes: Summary A case of primary lymphosarcoma of testis was studied by light and electron microscopy. The fine structure of the lymphosarcoma cells was simple and monotonous. The cytoplasm was scanty and contained normal-looking organelles. Free ribosomes were abundant and the Golgi apparatus was well developed. The nuclei were large and irregular in shape with prominent nucleoli. “Nuclear pockets” enclosing material similar to the cytoplasmic ground substance were found infrequently. Remnants of disintegrating cells were also encountered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304043
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  • 4
    Electronic Resource
    Electronic Resource
    Level of circulating phospholipase A2 in prediction of the prognosis of patients with suspected myocardial infarction (2000)
    Springer
    Basic research in cardiology 95 (2000), S. 413-417 
    Details
    ISSN: 1435-1803
    Keywords: Key words Atherosclerosis – infarction – inflammation – phospholipase A2 – prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives. Atherosclerotic lesions result from inflammatory-proliferative responses of the endothelium and smooth muscle of the arterial wall. Poor prognosis of acute myocardial infarction (AMI) patients has been associated with elevated levels of acute phase proteins including C-reactive protein. We investigated the significance of circulating phospholipase A2 in the long-term prognosis of suspected AMI patients. Methods. The concentration of phospholipase A2 was measured by an immunoassay in sera of 100 suspected AMI patients. Admission phospholipase A2 95% fractile outliers were excluded to eliminate the effect of acute infectious diseases. The total and atherosclerotic mortalities were followed for a 4-year period. Results. The most powerful prognostic limit for both admission (p=0.02, RR=2.6 and 95% CI=1.2 to 5.6) and maximal (p=0.06, RR=2.4 and 95% CI=0.96 to 5.9) phospholipase A2 groups was ≥ 8 μg/l. The admission phospholipase A2 level had an independent prognostic significance for atherosclerotic mortaligy (p=0.04, RR=2.4 and CI=1.02 to 5.8) in multivariate analysis with CK-MB and age. Conclusions. The eleated serum phospholipase A2 level at admission is an independent predictor of long-term atherosclerotic mortality in patients with suspected AMI. The prognostic significance of phospholipase A2 weakens during hospitalisation concomitant to the onset of the acute inflammatory response to myocardial injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003950070041
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of pancreatic exocrine secretion by vinblastine (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 163-168 
    Details
    ISSN: 1433-8580
    Keywords: Amylase secretion ; Exocrine pancreas ; Microtubules ; Vinca alkaloids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inbred BALB/c mice were given vinblastine sulfate (VelbeR) and/or pilocarpine hydrochloride (20 mg/kg) intraperitoneally and amylase activity was determined in the pancreas homogenate. When vinblastine was given 5 hours before measuring the pancreatic amylase content it inhibited the pilocarpine stimulated (2 hours) pancreatic secretion in a dosis-dependent fashion at doses 4, 40 and 400 mg/kg. Vinblastine (200 mg/kg) also delayed amylase accumulation during 3 hours in mice given vinblastine 2 hours after pilocarpine stimualtion. The results support the hypothesis that faultless function and integrity of microtubules might be a prerequisite of pancreatic acinar cell secretionin vivo. Other effects of vinblastine, such as interference with amino acid metabolism, anticholinergic action, and cell injury must also be considered when interpreting the present findings form the point of view of the secretory mechanism of the pancreatic acinar cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01854842
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