ISSN:
1433-8580
Keywords:
Pancreatic secretion in man
;
Secretin
;
Cholecystokininpancreozymin
;
Hypercalcemia
;
Hypocalcemia
;
Calcitonin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The influences of acute changes of the serum calcium and of calcitonin (CT) on the exocrine pancreatic function have been studied in man. During stimulation with secretin and cholecystokinin-pancreozymin (CCK-PZ) Ca++-glucolactobionate, Na2-EDTA, porcine and human synthetic CT were infused i.v. Hypercalcemia provoked an increase of enzyme secretion under unstimulated and secretin stimulated conditions; however, in the case of CCK-PZ administration enzyme output was not altered. EDTA-hypocalcemia inhibited pancreatic secretion during secretin as well as during CCK-PZ infusions. CT doses above 2 MRCU caused a decrease of enzyme secretion during simultanous secretin/CCK-PZ administration by about 70–80% of the initial value without decreasing serum Ca++; doses of 0.5 MRCU and less were without effect. In none of the experiments bicarbonate secretion was affected. The results show important changes of the pancreatic enzyme secretion during acute hyper- and hypocalcemia, while calcitonin exerts an inhibitory effect during normocalcemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01852252
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