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  • 1
    Electronic Resource
    Electronic Resource
    INFLUENCE OF THE PROGESTOGENIC COMPONENT OF ORAL CONTRACEPTIVES ON TRYPTOPHAN METABOLISM (1973)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 80 (1973), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients taking 0.05 mg. of ethinyl oestradiol and 2.5 mg. of lynestrenol (Minilyn) showed, at most, only a mild rise in xanthurenic acid excretion in urine, while very marked rises in xanthurenic acid secretion were found in patients taking 0.05 mg. of ethinyl oestradiol with 1 mg. of norethisterone (Minovlar), or 3 mg. of norethisterone (Gynovlar) or 1 mg. of ethynodiol diacetate (Ovulen 50). Patients taking 0.05 mg. of mestranol with 1 mg. of norethisterone (Norinyl 1) showed a smaller rise in the urinary excretion of kynurenine or 3-hydroxykynurenine than did those taking Minovlar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1973.tb02137.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    THE EFFECTS OF A PROGESTOGEN, MEGESTROL ACETATE, ON CARBOHYDRATE AND LIPID METABOLISM (1972)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 79 (1972), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The metabolic effects of the administration of megestrol acetate 0.5 mg. daily have been studied in 31 women. In 26 women (Group A) studied before and after daily megestrol acetate administration there were no changes in plasma glucose, plasma insulin, blood pyruvate, serum triglyceride and serum cholesterol levels. Significant decreases in plasma glucose and plasma insulin and in blood pyruvate levels during oral and intravenous glucose tolerance tests were observed in 17 women (Group B) on substituting daily megestrol acetate for a combined oestrogen-progestogen oral contraceptive (OC). In these women the fasting serum triglyceride and serum cholesterol levels also decreased. It is concluded that the daily administration of 0.5 mg. megestrol acetate does not alter carbohydrate or lipid metabolism. This may be an advantage over combined preparations. Offsetting this, however, was a fairly high incidence of side effects and in this small group, at least one method failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1972.tb12911.x
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  • 3
    Electronic Resource
    Electronic Resource
    Quantum metallicity in a two-dimensional insulator (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 409 (2001), S. 161-164 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One of the most far-reaching problems in condensed-matter physics is to understand how interactions between electrons, and the resulting correlations, affect the electronic properties of disordered two-dimensional systems. Extensive experimental and theoretical studies have shown that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35051516
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  • 4
    Electronic Resource
    Electronic Resource
    Seventh Annual Meeting of the European Association for the Study Of Diabetes Southampton, England, September 15–17, 1971 Abstacts, Part 1 (1971)
    Springer
    Diabetologia 7 (1971), S. 467-486 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212066
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  • 5
    Electronic Resource
    Electronic Resource
    Inter-relationship between insulin secretion and plasma free fatty acid and triglyceride transport kinetics in maturity onset diabetes and the effect of phenethylbiguanide (Phenformin) (1974)
    Springer
    Diabetologia 10 (1974), S. 119-130 
    Details
    ISSN: 1432-0428
    Keywords: Maturity onset diabetes ; kinetic measurements ; free fatty acid (FFA) ; triglyceride (TG) ; insulin ; post-heparin lipolytic activity (PHLA) ; hypertriglyceridaemia ; turnover rate ; influx rate clearance ; oral glucose tolerance test (O.G.T.T.)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The plasma free fatty acid and triglyceride transport kinetics in 16 non-obese and 7 obese maturity onset diabetics with hypertriglyceridaemia have been compared with results obtained in 27 control subjects. Changes in glucose and insulin responses were evaluated in relation to the lipid parameters. All the diabetics showed elevated plasma FFA levels and turnover rates. In the non-obese diabetics the plasma triglyceride turnover rate was within the normal range and their hypertriglyceridaemia was due to impaired triglceride clearance. In the obese diabetics the plasma triglyceride turnover rate was increased and they also had some impairment of triglyceride clearance, so that in them a double mechanism was observed to account for their hypertriglyceridaemia. The insulin levels in the diabetics were similar to, or greater than, those found in the controls. Our results suggested that the enhanced lipolysis and impaired triglyceride clearance observed in the diabetic patients were a manifestation of insulin unresponsiveness in adipose tissue and that the changes in insulin and glucose relationship could be secondary to elevated FFA and triglyceride levels. Further confirmation was obtained by the finding of an exaggerated insulin response to a glucose challenge in normal subjects infused with Intralipid. Treatment with phenethylbiguanide (Phenformin) significantly lowered the plasma FFA and triglyceride concentration in both diabetic groups. This was associated with normalisation of both plasma FFA turnover and triglyceride clearance. It also reduced the triglyceride turnover rate to the normal range in the obese diabetics. These changes were associated with a fall of plasma glucose and insulin levels to within the normal range. These results suggested an effect of Phenformin in reducing the rate of lipolysis leading to improved glucose tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219667
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    Paper (German National Licenses)
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