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  • 2000-2004  (8)
  • 1965-1969  (7)
  • 1905-1909  (3)
  • 11
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    Instinct and intelligence (1909)
    London, etc. : Periodicals Archive Online (PAO)
    British journal of psychology. 3 (1909/1910) 219 
    Details
    ISSN: 0007-1269
    Topics: Psychology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0047-1909-003-00-000011
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  • 12
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    The Interpretation of Nature (1905)
    London : Periodicals Archive Online (PAO)
    The Contemporary Review. 87 (1905:Jan./June) 609 
    Details
    ISSN: 0010-7565
    Topics: General, Interdisciplinary
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0274-1905-087-00-000050
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  • 13
    Electronic Resource
    Electronic Resource
    Plasma TGF-β1 as a risk factor for gingival overgrowth (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background and Aims: Induction of the pro-fibrotic growth factor TGF-β1 has been suggested as a possible mechanism through which immunosuppressant drugs may induce gingival overgrowth. This study aims to investigate plasma levels of TGF-β1 and relate them to the development and severity of gingival overgrowth in immunosuppressed transplant patients.Materials and Methods: One hundred and thirty-two ciclosporin-treated and 13 tacrolimus-treated transplant patients and 24 drug-free control subjects underwent a full periodontal examination including a determination of the presence and severity of gingival overgrowth.Results: Plasma TGF-β1 concentrations were determined by ELISA, and were found to be significantly elevated in samples from the transplant patients (mean=29.1 ng/ml) as compared with controls (mean=6.1 ng/ml, p〈0.0001). There was no significant difference between the levels of plasma TGF-β1 in the ciclosporin- and tacrolimus-treated patient groups.Conclusions: Furthermore, concomitant treatment with calcium channel blockers did not influence the levels of plasma TGF-β1 in the patients group. The relationship between gingival overgrowth, independent periodontal variables and TGF-β1 plasma concentrations was examined using univariate and multivariate regression analyses; low TGF-β1 plasma concentrations were found to be a risk factor for gingival overgrowth in immunosuppressed patients concomitantly receiving a calcium channel blocker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00572.x
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  • 14
    Electronic Resource
    Electronic Resource
    A survey of physicians' attitudes to transfusion practice in critically ill patients in the UK (2002)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 57 (2002), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary This study aimed to examine the attitudes of intensivists and haematologists to the use of blood and blood products using a scenario-based postal questionnaire. One hundred and sixty-two intensivists and 77 haematologists responded to the survey. In four scenarios, the baseline haemoglobin thresholds for red cell transfusion ranged from 6 to 12 g.dl−1. There was significant variation between scenarios (p 〈 0.005). Increasing age, high Acute Physiology and Chronic Health Status II score, surgery, acute respiratory distress syndrome, septic shock and lactic acidosis significantly (p 〈 0.005) modified the transfusion threshold. There were greater variations in the baseline threshold for platelet transfusion. The majority of respondents (72.3%) selected a baseline haemoglobin threshold between 9 and 10 g.dl−1. The thresholds for platelet transfusion were far less consistent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2002.02509_1.x
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  • 15
    Electronic Resource
    Electronic Resource
    Blood component use in critically ill patients (2002)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 57 (2002), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary This prospective observational study was conducted to assess the current transfusion practice in critically ill patients. One thousand two hundred and forty-seven consecutive critically ill patients admitted between February 1999 and October 1999 were included in the study. Overall 666 (53%) patients were administered red cells. Transfused patients had significantly higher intensive care unit␣mortality but also had higher Acute Physiology and Chronic Health Evaluation II scores and longer durations of stay. The average pretransfusion haemoglobin concentration was 〈 9 g.dl−1 in 75% of transfusion episodes. The common indications for transfusion were low haemoglobin (72%) and haemorrhage (25%). Overall, 202 (16%) and 281 (22%) of the patients were transfused platelets and fresh frozen plasma, respectively. The indications for transfusion were haemorrhage, low platelet counts, prolonged prothrombin time or to provide cover for invasive interventions. Most platelet transfusions were given at values in the order of 50–100 × 109.l−1. The pretransfusion platelet count varied according to the indications for transfusion. This study showed that transfusion practice is consistent and that in general there does not seem to be an excessive use of blood components in critically ill patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2002.02514.x
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  • 16
    Electronic Resource
    Electronic Resource
    Effects of Induced drinking on self-stimulation of the Lateral Hypothalamus (1967)
    Springer
    Experimental brain research 3 (1967), S. 111-116 
    Details
    ISSN: 1432-1106
    Keywords: Drinking ; Electrical stimulation ; Hypothalamus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats with chronic electrodes in the lateral hypothalamus were induced by electrical stimulation to self-stimulate and drink. The effect of this artificially-elicited drinking on self-stimulation behavior was investigated. Self-stimulation rates at optimal current levels were not changed by induced water intake. However, with the current level just above threshold for self-stimulation the rate was increased significantly when the animals were able to self-stimulate and drink simultaneously. It is suggested that sensory feed-back from the consummatory behavior facilitates the activation of neural circuits in the lateral hypothalamus so that low current stimulation more effectively reinforces self-stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233256
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  • 17
    Electronic Resource
    Electronic Resource
    Structures of 5-Bromodeoxyuridine and 5-Bromouridine (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1230-1232 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] By means of X-ray crystal analysis we have investigated the structure of 5-bromodeoxyuridine (BUDR) and that of the closely related 5-bromouridine (BUR). These molecules differ by only one oxygen atom (Fig. 1), and it is of interest to see what differences exist between their conformations. BUDR ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091230b0
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  • 18
    Electronic Resource
    Electronic Resource
    Acute renal failure following cardiopulmonary bypass: a changing picture (2000)
    Springer
    Intensive care medicine 26 (2000), S. 565-571 
    Details
    ISSN: 1432-1238
    Keywords: Key words Cardiopulmonary bypass ; Acute renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess the incidence of acute renal failure (ARF) developing perioperatively in adult patients requiring cardiopulmonary bypass surgery (CPB) and to make comparisons with data from the same institution published earlier. Design: Prospective, observational. Setting: Tertiary referral centre for cardiopulmonary medicine. Patients and participants: All patients admitted to the intensive care unit (ICU) who developed ARF perioperatively necessitating continuous veno-venous haemofiltration (CVVH) during the 24 months January 1997–December 1998. Interventions: None. Measurements and results: Of 2337 adult patients undergoing cardiac surgery, 47 (2.0 %) needed CVVH. Patients were excluded from analysis who underwent cardiac transplantation (n = 4), pericardial surgery (n = 3) or insertion of a left ventricular assist device (n = 1). Of the remaining 39, 21 patients died in ICU (53.8 % mortality). Relatively more non-survivors suffered from diabetes, hypertension and preoperative renal dysfunction. A previous report from our Unit revealed that, in 1989–90, 2.7 % of all patients undergoing CPB required CVVH with an in-hospital mortality of 83 %. The current study population were older (65.3 vs 56.0 years in 1990), and more severely ill as evidenced by a higher percentage of patients requiring redo (30 % vs 8.6 % in 1990) and emergency (50 % vs 25.7 % in 1990) surgery. Conclusions: The need for CVVH following CPB may be diminishing despite increased risk factors. ARF-associated mortality in these circumstances is falling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051205
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