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  • 1
    Digitale Medien
    Digitale Medien
    Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches (2002)
    Oxford, UK : Blackwell Science Ltd
    BJOG 109 (2002), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To evaluate the efficacy of low-dose acetylsalicylic acid in the prevention of pregnancy-induced hypertension and intrauterine growth retardation in high-risk pregnancies as determined by transvaginal Doppler ultrasound study of the uterine arteries at 12 to 14 weeks of gestation.Design Randomised, double blind and placebo-controlled trial.Setting The Department of Obstetrics and Gynaecology, Tampere University Hospital, Finland.Population One hundred and twenty pregnant women considered to be at high risk of pre-eclampsia or intrauterine growth retardation were screened by transvaginal Doppler ultrasound at 12 to 14 weeks of gestation.Methods Ninety pregnant women with bilateral notches in the uterine arteries were randomised to receive acetylsalicyclic acid 0.5mg/kg/day (n= 45) or placebo (n= 45) from 12 to 14 weeks of gestation.Main outcome measures Hypertensive disorders of pregnancy and intrauterine growth retardation.Results Forty-three women on acetylsalicyclic acid and 43 on placebo were successfully followed up. The use of acetylsalicyclic acid was associated with a statistically significant reduction in the incidence of pregnancy-induced hypertension (11.6%vs 37.2%, RR = 0.31, 95% CI 0.13–0.78) and pre-eclampsia (4.7%vs 23.3%, RR = 0.2, 95% CI 0.05–0.86). The incidence of hypertension before 37 weeks of pregnancy was also significantly reduced (2.3%vs 20.9%, RR = 0.22, 95% CI 0.05–0.97). The reduction in the incidence of intrauterine growth retardation (2.3%vs 7%) was not statistically significant. Acetylsalicyclic acid was not associated with excess risk of maternal or fetal bleeding.Conclusion In women rated in Doppler velocimetry waveform analysis to be at high risk of pre-eclampsia, low-dose acetylsalicyclic acid reduces the incidence of pregnancy-induced hypertension and especially proteinuric pre-eclampsia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.2002.01046.x
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  • 2
    Digitale Medien
    Digitale Medien
    Quantification and normalization of gene expression using SYBR Green I real-time RT-PCR (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 27 (2001), S. 92-92 
    Details
    ISSN: 1546-1718
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] We have developed a two-step, real-time, quantitative assay, using the polymerase chain reaction with reverse transcription (RT-PCR) and based on SYBR Green I monitoring of PCR product accumulation, for quantification and normalization of gene expression levels. Because housekeeping gene expression ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/87340
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  • 3
    Digitale Medien
    Digitale Medien
    Osteoporosis After Gastrectomy: Bone Mineral Density of Lumbar Spine Assessed by Dual-Energy X-ray Absorptiometry (2000)
    Springer
    Calcified tissue international 66 (2000), S. 119-122 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Osteoporosis — Gastrectomy — Dual-energy X-ray absorptiometry — Bone mineral density — Metabolic bone disease.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Although osteoporosis is a common clinical disorder associated with gastric surgery, long-term effects of gastrectomy on bone metabolism are still unclear. The purpose of this study was to clarify the incidence and risk factors of osteoporosis after gastrectomy using univariate and multivariate analyses of quantitative measurements. The study included 59 patients who had undergone gastrectomy more than 5 years before. There were 38 men and 21 women, aged 37–81 years, mean 64 years. Bone mineral density (BMD) of L2–L4 spine was measured using dual-energy X-ray absorptiometry (DXA). Absolute value of BMD (g/cm2) and age- and sex-matched BMD (%) were given. The mean BMD was 0.766 g/cm2, and the incidence of osteoporosis (BMD less than 0.70 g/cm2) was 37%: 18% in men and 71% in women. The mean age- and sex-matched BMD was 85.9%: 87.5% in men and 83.1% in women. Univariate and multivariate analyses revealed that BMD was significantly associated with the age and sex of patients, but was not influenced by the type of gastrectomy (partial versus total) and years after operation (〈20 versus 20〈). Our study clarified the fact that postgastrectomy osteoporosis was frequent in the aged or female patients. BMD should be evaluated after gastrectomy, especially in the aged and in women.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002230010025
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  • 4
    Digitale Medien
    Digitale Medien
    Ultracentrifugal equilibrium measurement of high polymer solutions at elevated temperatures (1967)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-2: Polymer Physics 5 (1967), S. 277-288 
    Details
    ISSN: 0449-2978
    Schlagwort(e): Physics ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: To investigate the solution properties of polyethylene, which has the simplest structure of the vinyl polymers, experiments were made with a magnetically suspended equilibrium ultracentrifuge. Preliminary studies were carried out with a polystyrene-chloroform system at 25°C. and a polystyrene-methylcyclohexane system at 68°C. (which is close to the theta temperature) in order to check the difficulties involved in the flotation equilibrium in the former case and the high temperature measurement in the latter. However, no trouble was encountered in either system, and the results were discussed and compared with earlier results for polystyrene solutions. It was found that chloroform is a good solvent for polystyrene, and the measured weight-average molecular weight is somewhat smaller than the value obtained in a theta solvent. After overcoming some technical difficulties involved in studies at higher temperatures, we carried out experiments on polyethylene in α-chloronaphthalene at 130°C. The results are considered reasonable by comparison with results obtained by other methods. The sample employed, Marlex 50 of melt index 0.7, has a wide molecular weight distribution: i.e., Mz/Mw = 5.2 and Mz+1/Mz = 2.4.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pol.1967.160050204
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