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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human lumbar CSF patterns of Aβ peptides were analysed by urea-based β-amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Aβ-SDS–PAGE/immunoblot). A highly conserved pattern of carboxyterminally truncated Aβ1–37/38/39 was found in addition to Aβ1–40 and Aβ1–42. Remarkably, Aβ1–38 was present at a higher concentration than Aβ1–42, being the second prominent Aβ peptide species in CSF. Patients with Alzheimer's disease (AD, n = 12) and patients with chronic inflammatory CNS disease (CID, n = 10) were differentiated by unique CSF Aβ peptide patterns from patients with other neuropsychiatric diseases (OND, n = 37). This became evident only when we investigated the amount of Aβ peptides relative to their total Aβ peptide concentration (Aβ1–x%, fractional Aβ peptide pattern), which may reflect disease-specific γ-secretase activities. Remarkably, patients with AD and CID shared elevated Aβ1–38% values, whereas otherwise the patterns were distinct, allowing separation of AD from CID or OND patients without overlap. The presence of one or two ApoE ε4 alleles resulted in an overall reduction of CSF Aβ peptides, which was pronounced for Aβ1–42. The severity of dementia was significantly correlated to the fractional Aβ peptide pattern but not to the absolute Aβ peptide concentrations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 15 (2004), S. 0 
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction: Modification of AV nodal conduction by radiofrequency ablation (RFA) results in a variable reduction in heart rate during atrial fibrillation (AF). Using AF induced in patients with dual AV nodal pathways as a model, we tested the effect of additional treatment with digitalis (ouabain) and beta-blocker (esmolol). Methods and Results: Ten patients were randomized to control (group I) and studied only before ablation. AF was induced in 30 patients before and after slow pathway ablation (group II). Mean ventricular cycle lengths (AF CLmean) were recorded. Slow pathway conduction was eliminated after ablation in 10 patients (group IIA), whereas slow pathway conduction was still present in 20 patients (group IIB). Compared to pre-RFA there was a 10% increase in AF CLmean post-RFA (P 〈 0.01). During isoproterenol infusion the increase was 8% (P = NS). Adding digitalis and beta-blocker during isoproterenol infusion increased AF CLmean by 75% (95% in group IIA) compared to 36% in group I (P 〈 0.001 II vs I). Conclusion: Slow pathway ablation reduces ventricular rate during AF. Addition of digitalis and beta-blocker during isoproterenol infusion significantly decreases ventricular rate after ablation compared to the control group. The finding suggests that beta-blocker has significant effects on fast AV nodal pathway conduction during induced AF with isoproterenol infusion.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 6 (1934), S. 187-188 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 24 (1932), S. 547-548 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 56 (1934), S. 1314-1315 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 56 (1934), S. 1393-1394 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 24 (2001), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: ANFINSEN, O.-G., et al.: When Should Heparin Preferably be Administered During Radiofrequency Catheter Ablation? RF catheter ablation is complicated by thromboembolism in about 1% of patients. Limited knowledge exists concerning when and how to use anticoagulation or antithrombotic treatment. We studied the activation of coagulation (prothrombin fragment 1 + 2 [PF1 + 2] and D-dimer), platelets (β-thromboglobulin [β-TG]) and fibrinolysis (plasmin-antiplasmin complexes [PAP]) during RF ablation of accessory pathways in 30 patients. They were randomized to receive heparin (100 IU/kg, intravenously) (1) immediately after introduction of the femoral venous sheaths (group I) or (2) after the initial electrophysiological study, prior to the delivery of RF current (groups II and III). Group II additionally received saline irrigation of all femoral sheaths. After the initial bolus, 1,000 IU of heparin was supplied hourly in all groups. Within groups II and III, median plasma values of PF1 + 2 and β-TG more than tripled (P ≤ 0.007) during the diagnostic study and gradually declined during heparin administration despite RF current delivery. Median D-dimer tripled (P = 0.005) and PAP doubled (NS) before heparin administration; then both remained around the upper reference values. In the early heparin group, however, PF1 + 2, Ddimer, and PAP did not rise at all, and β-TG showed only a slight increase towards the end of the procedure. The differences between group I versus groups II and III were statistically significant prior to the first RF current delivery (PF1 + 2, D-dimer, and β-TG) and by the end of the procedure (PF1 + 2, D-dimer, and PAP). In conclusion, “late” heparin administration allows hemostatic activation during the initial catheterization and diagnostic study. By administering intravenous heparin immediately after introduction of the venous sheaths, hemostatic activation is significantly decreased. Saline irrigation of the venous sheaths added nothing to late heparin administration.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 309-314 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Odontogene Zyste ; Laterale parodontale Zyste ; Botryoide odontogene Zyste ; Kieferzyste ; Zytokeratine ; Keywords Odontogenic cyst ; Lateral periodontal cyst ; Botryoid odontogenic cyst ; Jaw cyst ; Cytokeratins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The botryoid odontogenic cyst (BOC) is considered a rare multilocular variant of the lateral periodontal cyst. The origin of the BOC can be seen in aberrant odontogenic tissue. The BOC is found especially in the premolar region of the mandible, as well as in the frontal region of the maxilla of patients aged between 60 and 70 years. Most of the 11 published articles of BOC have shown high rates of recurrence. Histopathologically the BOC is marked by multilocular cysts lined by a thin, nonkeratinized epithelium. Clusters of glycogen-rich epithelial cells may be noted in nodular thickenings of the cyst lining. For the clinician, the differentiation of the BOC from the keratocyst and ameloblastoma is ¶relevant. One case of a large BOC (65-year-old male, BOC regio 33–45, diameter 5 cm, radiographically and histologically multilocular) is presented with a review of the literature, including the therapeutic management, and the possible diagnostic criteria are discussed. The immunohistochemically determined expression of cytokeratin (CK) 13 implicates the histogenetic origin of the BOC from the squamous epithelium of the oral cavity and excludes the origin from the small salivary glands. The expression of CK 19 and the lack of expression of p53, as well as the higher proliferation rate of the basal epithelial cell layer by the BOC, may be useful for distinction between the keratocyst.
    Notes: Zusammenfassung Die botryoide odontogene Zyste (BOC) ist eine seltene multilokuläre Variante der lateralen parodontalen Zyste. Sie entsteht aus versprengten odontogenen Zellanteilen. Die BOC tritt besonders häufig im Prämolarenbereich des Unterkiefers und im anterioren Oberkiefer bei Patienten zwischen der 6. und 7. Lebensdekade auf. Unter den bisher publizierten 11 Arbeiten zeigt sich eine hohe Rezidivhäufigkeit. Histologisch ist die BOC durch multilokuläre Zysten mit einem isomorphen Epithel gekennzeichnet. Dieses zeigt fokale plaqueähnliche Verdickungen durch Gruppierungen glykogenreicher Plattenepithelzellen. Für den Kliniker ist die Abgrenzung zur Keratozyste bzw. zum Ameloblastom differentialdiagnostisch bedeutsam. Ein Zufallsbefund einer besonders großen BOC (65 Jahre, männlich, BOC-Regio 33–45, 5 cm Durchmesser, radiologisch und histologisch multilokulär) wird inklusive therapeutischem Vorgehen und Literaturübersicht vorgestellt, mögliche Diagnosekriterien werden diskutiert. Der immunhistochemische Nachweis der Expression von CK13 impliziert eine histogenetische Ableitung der BOC vom oralen Plattenepithel und spricht gegen eine Ableitung von den Speicheldrüsen. Die Expression von CK19 und die fehlende Expression des p53 sowie die hohe Proliferation in der Basalzellschicht durch die BOC können zur Abgrenzung von der Keratozyste benutzt werden.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1436-5073
    Keywords: Key words: Structure elucidation; trace analysis; degradation products of dinitrotoluene and toluylenediamine; LC/ESI-MS.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract.  The structure elucidation of some intermediates of the transformation of dinitrotoluene and toluylenediamine isomers is described. Methylnitroanilines, quinoxalines, benzimidazoles and cresols were identified using GC/MS, LC/MS and LC and UV detection. The separation of compounds from the aqueous phase was carried out by solid phase extraction with various column packings. The origin of the purification plant residue coloring is clarified and the related sources and possible pathways of formation of some compounds are given. Finally the results of biodegradation and ecotoxicological experiments [1] are discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 367 (2000), S. 679-685 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Optimum experimental factors were determined for the analytical determination of Al, Cd, Fe, Pb, and Zn by ICP atomic emission spectrometry. Based on systematically determined factor levels, working conditions were found that gave similiar, and sometimes better results compared with the hitherto used levels of factors. All measurements were performed with a sampling time of 150 ms as often used in routine analysis in the laboratory. This optimization resulted in a reduced outer plasma gas flow from 15 L/min argon to 12 L/min without any relevant changes of the achievable detection limits. A serious problem was that only one analytical line of Al could be used. A comparison with the lower limit of application (comparable with the detection limit) from German directive DIN 38406, part 22 ([1]), showed that the detection limits of Al and Fe are superior, whereas for Cd there was only little improvement. The detection limits of Zn and especially Pb are always higher than the lower range of application under these conditions. Therefore, the use of two device-parameter sets for hard and soft lines, respectively, is strongly suggested. Maps with the observed signal-to-noise-ratios were systematically acquired for each element analyzed in connection with different strategies for optimum search.
    Type of Medium: Electronic Resource
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