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  • 11
    Electronic Resource
    Electronic Resource
    Prognosis and work absence due to occupational contact dermatitis (2002)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 46 (2002), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The consequences of a diagnosis of occupational contact dermatitis (OCD) were investigated using cases available from the voluntary surveillance scheme, EPIDERM. Cases of OCD reported from November 1994 to September 1995 were identified and sampled to give at least 100 cases of allergic, irritant and mixed OCD reported by consultant dermatologists (344 cases) and occupational physicians (377 cases). A questionnaire was sent to the reporting physician to elicit further information. 512 completed questionnaires were returned, of which 510 were eligible for analysis. Among cases reported by dermatologists (n = 286) and occupational physicians (n = 224), 7% (6.3%) had been unemployed and 16.8% (20.1%) had taken sick leave. 3 factors independently predicted time off work in a logistic regression analysis: age OR = 1.25 (95% CI, 1.05–1.49), allergic dermatitis OR = 1.77 (95% CI, 1.13–2.79) and medicolegal assessment OR = 4.42 (95% CI, 2.20–8.89). Overall, 15.7% did not improve clinically between the first and last visit. Those who did not improve had been exposed to the agent for longer (mean 7.6 years) than those who did (5.3 years) (p = 0.09). In patients ≤ 45 years, those reported to be atopic failed to improve (25.4%) more often than those not atopic (13.4%) (p = 0.04). The substantial numbers (21%) with time off work and with persistent dermatitis suggest that OCD continues to have a significant impact on workers and their employers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2002.460505.x
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  • 12
    Electronic Resource
    Electronic Resource
    Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Human rhinoviruses (RVs) are the most common precipitants of asthma exacerbations. RV infection of bronchial epithelium results in local airway inflammation inducing eosinophil recruitment and activation. Induction of eosinophil chemoattractants could represent a central mechanism, as well as a prime target for intervention.Objective To assess the effect of RV infection on mRNA expression and production of eosinophil chemoattractants by bronchial epithelial cells in-vitro.Methods BEAS-2B cells were infected with major and minor RVs and the mRNA expression of IL-8, RANTES, MIP-1α, eotaxin, eotaxin-2, MCP-2, MCP-3 and MCP-4 was assessed by reverse transcription PCR. In cases where mRNA induction was observed, a fluoroimmunoassay was used to confirm protein production. To assess the virus-specificity of the observed reactions, cells were also exposed to inactivated RVs.Results RV infection was able to up-regulate mRNA expression of IL-8, RANTES, MIP-1α, eotaxin and eotaxin-2, did not affect MCP-4, while MCP-2 and MCP-3 were not expressed either at baseline or after virus infection. Protein production was confirmed for IL-8, RANTES and eotaxin, but not for MIP-1α. When RVs were inactivated cytokine up-regulation was almost completely lost.Conclusion Infection of bronchial epithelial cells with RVs results in the production of a wide array of mediators that are able to chemoattract eosinophils. These include the eosinophil-specific molecules eotaxin and eotaxin-2, in addition to IL-8 and RANTES, which are the most abundant. Eosinophil recruitment after RV infection of bronchial epithelium could represent a central event in the pathogenesis of virus-induced asthma exacerbations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01112.x
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  • 13
    Electronic Resource
    Electronic Resource
    The change from water to salt as the main vehicle for community-wide fluoride exposure in Basle, Switzerland (2003)
    Oxford, UK : Munksgaard International Publishers
    Community dentistry and oral epidemiology 31 (2003), S. 0 
    Details
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1600-0528.2003.00123.x
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  • 14
    Electronic Resource
    Electronic Resource
    Distribution of metals during digestion by cutthroat trout fed benthic invertebrates contaminated in the Clark Fork River, Montana and the Coeur d'Alene River, Idaho, U.S.A., and fed artificially contaminated Artemia (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 56 (2000), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The concentrations of essential amino acids in three, undigested invertebrate diets collected from the Clark Fork River (CFR) for cutthroat trout were similar to each other, but were c. 25–75% less than Artemia that were exposed to a mixture of arsenic, copper, cadmium, lead and zinc in the laboratory. The Artemia diet appeared less palatable and the texture, quantity and appearance of the intestinal contents differed between fish fed the Artemia and CFR diets. The Pb% in the fluid fraction of the intestinal contents was greater for the Artemia (29%) than for the CFR diets (10–17%), and the Cu% in the amino acid plus metal fraction of the intestinal contents was greater for the Artemia (78%) than for two of the three CFR diets (67% and 70%). Intestinal contents of fish fed invertebrate diets collected from various sites on the Coeur d'Alene River (CDA), Idaho, were similar in texture, quantity, and appearance. For fish fed the CDA diets, differences in the distribution of metals among fractions of the digestive fluids appeared to be related to concentrations of metals in the invertebrate diets. Pb% was lowest of all metals in the fluid portion of the intestinal contents. However, 〉80% of all metals in the hind gut were associated with the particulate fraction where they may still be available for uptake through pinocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2000.tb02093.x
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  • 15
    Electronic Resource
    Electronic Resource
    A fixed allele at microsatellite locus LS-39 exhibiting species-specificity for the black caviar producer Acipenser stellatus (2001)
    Oxford UK : Blackwell Science Ltd.
    Journal of applied ichthyology 17 (2001), S. 0 
    Details
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The sturgeon microsatellite LS-39 was amplified across 10 different species of Acipenserinae and exhibited the potential to identify the black caviar producer Acipenser stellatus on a genomic DNA level. This was because of a fixed allele of 111 bp, which was absent in the other species which were investigated. Concerning the source of sturgeon species, LS-39 is the first nuclear marker described to examine black caviar. Furthermore, new light is shed on the controversial ploidy state of sturgeons. The present authors findings at this microsatellite locus support the hypothesis that extant ~120 chromosomal species are modern diploids, whereas sturgeons with ~240 chromosomes should be considered as modern tetraploids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0426.2001.00234.x
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  • 16
    Electronic Resource
    Electronic Resource
    Aggressive periodontitis – what exactly is it? (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00602.x
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  • 17
    Electronic Resource
    Electronic Resource
    A sub-atomic microscope, superfocusing in channeling and close encounter atomic and nuclear reactions (2004)
    Springer
    The European physical journal 42 (2004), S. 361-365 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. A highly collimated beam of protons ( $\approx$ 1 MeV) entering the channel of a monocrystal film forms at a certain depth an extremely sharp (〈0.005 nm) and relatively long (some monolayers of the crystal) focusing area where the increase of the flux density can reach thousand times. Impinging atoms in this focusing area can undergo nuclear or atomic reactions with proper foreign dopants which disappear if the crystal is tilted from this position by only 10-3 radians. This effect can be called channeling superfocusing, in contrast to the ordinary fluxpeaking where the increase of flux density reaches only few times. Results are predicted by quantum mechanical model calculations and confirmed by channeling Monte Carlo simulations accounting for several properties of the real lattice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjb/e2004-00391-6
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  • 18
    Electronic Resource
    Electronic Resource
    Micromachined, Polyimide-Based Devices for Flexible Neural Interfaces (2000)
    Springer
    Biomedical microdevices 2 (2000), S. 283-294 
    Details
    ISSN: 1572-8781
    Keywords: neural prostheses ; MEMS ; polyimide ; electrical stimulation ; implant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Micromachining technologies were established to fabricate microelectrode arrays and devices for interfacing parts of the central or peripheral nervous system in case of neuronal disorders. The devices were part of a neural prosthesis that allows simultaneous multichannel recording and multisite stimulation of neurons. Overcoming the brittle mechanics of silicon, we established a process technology to fabricate light-weighted and highly flexible polyimide based devices. Concerning the challenging housing demands close to the nerve to prevent mechanical induced nerve traumatization, we integrated interconnects to decouple the nerve interface from plugs and signal processing electronics. Hybrid integration with a new assembling technique—the MicroFlex interconnection (MFI)—has been applied for the connection of the flexible microsystems to silicon microelectronics. In this paper, we present different shapes and applications of the flexible electrodes: sieve electrodes for regeneration studies, cuff electrodes for interfacing peripheral nerves, and a retina implant for ganglion cell stimulation. The discussion is focused on electrode and material properties and the hybrid assembly of a fully implantable neural prosthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009955222114
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  • 19
    Electronic Resource
    Electronic Resource
    Evidence for deformation in 113-116Cd isotopes (2000)
    Springer
    The European physical journal 7 (2000), S. 347-353 
    Details
    ISSN: 1434-601X
    Keywords: PACS: 21.60.Ev Collective models – 21.60.Jz Hartree-Fock – 23.20.Lv Gamma transitions and level energies – 25.70.Jj Fusion and fusion-fission reactions – 27.60.+j 90 ≤ A ≤ 149
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: High-spin states in 113-116Cd have been investigated with the fusion-fission reaction 28Si +176Yb at 145 〉 MeV. The experiment has been performed with the Eurogam2 array. New rotational bands based on two quasi-particle states have been observed for even-even cadmium isotopes. A new level scheme based on the 11/2− isomeric state is proposed for 115Cd and the one of 113Cd has been extended to spin (31/2−). The decoupled bands identified in both odd-A nuclei are interpreted as being built upon a low-Ωh11/2 quasi-neutron configuration. Microscopic Hartree-Fock + BCS calculations confirm the prolate deformation in this mass region especially for the odd cadmium isotopes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013614
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  • 20
    Electronic Resource
    Electronic Resource
    Physiologische Auswirkungen einer Zerstörung der Tip-Links kochleärer Haarsinneszellen Bedeutung für die lärminduzierte Schädigung des Gehörs (2000)
    Springer
    HNO 48 (2000), S. 383-389 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Tip-Link-Hypothese ; Lärmschwerhörigkeit ; Schalltrauma ; Tinnitus ; TTS ; Key words Tip link hypothesis ; Noise-induced hearing loss ; Tinnitus ; TTS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Sound overexposure is known to cause damage to cochlear structures and can induce permanent or temporary hearing loss and tinnitus. Perhaps the most sensitive of these structures to sound overexposure are the tip links. In this paper the elecrophysiological effects of pharmacological destruction of the tip links of outer hair cells was investigated. Outer hair cells treated with elastase (20 U/mL) or BAPTA (5 mM) no longer responded to sinusoidal stimuli. In contrast to common belief, transduction channels opened due to loss of tip links. Such opened channels can allow K+ and Ca2+ to enter the cell from the endolymphatic space and could lead to permanent depolarization. This influx of cations caused by loss of tip links, together with the subsequent hair-cell depolarization, might be a source of sensorineural hearing loss and tinnitus associated with acoustic trauma.
    Notes: Zusammenfassung Eine extreme Lärmexposition ist bekannt dafür, Schädigungen des Gehörs hervorzurufen, die sich in permanenter oder temporärer Schwerhörigkeit und Tinnitus manifestieren können. Vor allem die Stereozilien der Haarsinneszellen stellen einen sensiblen Angriffspunkt dar: deren rämliche Ordnung und ihre Verbindungsfilamente (Tip-Links) können zerstört werden. In der vorliegenden Arbeit wurde die Auswirkung einer pharmakologischen Zerstörung der Tip-Links auf das elektrophysiologische Verhalten der Zelle untersucht. Es zeigte sich, dass die behandelten äußeren Haarsinneszellen nicht mehr mechanosensitiv für nasische Stimuli waren, was die Wichtigkeit der Tip-Links bei der Reiztransduktion unterstreicht. Entgegen der allgemeinen Erwartung gingen die mechanoelektrischen Transduktionskanäle aber in einen offenen Zustand über. Durch die permanent offenen Kannäle strömen dauerhaft hauptsächlich K+- und Ca2+-Ionen aus der Endolymphe in die Zelle ein und führen zu einer Depolarisation. Dieser durch den Verlust der Tip-Links verursachte Einstrom von Kationen und die Depolarisation der Zelle können ein Teil der Ursache einer dem Schalltrauma begleitenden Symptomatik wie Innenohrschwerhörigkeit und Tinnitus sein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050585
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