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  • 2000-2004  (2)
  • Alzheimer's disease  (1)
  • Key words: Nasopharyngeal carcinoma – Pattern of tumor extent – Cervical lymph node metastasis – MR imaging – Radiation therapy  (1)
  • non-human primate  (1)
  • 36.40. + d
  • Brain abscess
  • Cerebritis
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Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    MR analysis of nasopharyngeal carcinoma: correlation of the pattern of tumor extent at the primary site with the distribution of metastasized cervical lymph nodes. Preliminary results (2000)
    Springer
    European radiology 10 (2000), S. 970-977 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Nasopharyngeal carcinoma – Pattern of tumor extent – Cervical lymph node metastasis – MR imaging – Radiation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to correlate the pattern of tumor extent of nasopharyngeal carcinoma at the primary site on magnetic resonance (MR) imaging with the distribution of cervical lymph node metastasis. MR images of 32 patients with biopsy-proven nasopharyngeal carcinoma were reviewed and classified into five patterns of tumor extent in correlation with the distribution of cervical lymphadenopathy. The assessment of cervical lymph node metastasis was done on the basis of the computed tomography (CT) findings. The tumor volume was also correlated with the occurrence of contralateral lymphadenopathy. Of the 32 patients, five (16 %) presented as type 1, tumor limited to the nasopharyngeal mucosa; 12 (38 %) as type 2 a, tumor which had invaded either lateral side but did not extend over the roof of nasopharynx; three (9 %) as type 2 b, tumor which had invaded bilaterally across the midline but did not extend over the roof of nasopharynx; three (9 %) as type 2 c, tumor which had invaded mainly the skull base but did not cross the midline; and nine (28 %) as type 3, tumor which had extended anteriorly to the nasal cavity without invasion. Twenty-five patients (78 %) demonstrated cervical lymphadenopathy. Patients with type 1, type 2 b and type 3 spread had frequent bilateral cervical lymphadenopathy; those with type 2 a had only ipsilateral lymphadenopathy. There was statistical significance (P 〈 0.005) regarding the existence of contralateral lymphadenopathy with midline tumors as well as the absence of contralateral cervical lymphadenopathy with non-midline tumors. This study therefore suggests that the distribution of metastasized lymph nodes depends on the pattern of tumor extent at the primary site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300051047
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Naturally occurring and experimentally induced β-amyloid deposits in the brains of marmosets (Callithrix jacchus) (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 799-814 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Amyloid ; marmoset ; non-human primate ; Alzheimer's disease ; aging ; senile plaques ; cerebrovascular amyloid.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Cerebral β-amyloid occurs in elderly animals of some species and in Alzheimer's disease. Previously, we injected 3 young marmosets intracerebrally with brain tissue from a patient with Alzheimer's disease. Six years later, when the monkeys were middle aged, we found moderate numbers of intracerebral plaques and cerebrovascular deposits containing β-amyloid. We have re-examined these brains and those of 10 other marmosets injected with brain homogenate containing β-amyloid, and have found some β-amyloid in animals injected more than 4 years previously. We have found β-amyloid in 4 of 26 elderly control marmosets, but not in 9 young to middle-aged control marmosets. The β-amyloid found in middle aged marmosets injected with Alzheimer brain tissue was, therefore, not a consequence of their age. Deposits in large cerebral vessels in elderly marmosets, and in marmosets previously injected with brain tissue containing β-amyloid, reacted with antibodies to Aβ and Aβ1-40; plaques and microvessel deposits reacted with antibodies to Aβ and Aβ1-42.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070060
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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