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  • 1
    ISSN: 1432-0533
    Keywords: Key words Amyloid ; Apolipoprotein E ; Prion ; Squirrel monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction of various amyloid precursors and apolipoprotein E (apoE) is important for Congophilic amyloid formation. As for cerebral amyloidoses, although the correlation between amyloid β protein (Aβ) and apoE in Alzheimer’s disease (AD) has been clarified, the interaction of prion protein isoform (PrPsc) and apoE in several types of prion diseases (PDs) has not been examined in detail. ApoE colocalization has been confirmed in Congophilic PrPsc plaques, but to clarify the participation of apoE in the early stage of PDs, apoE deposition in immature lesions without Congophilic amyloid in PDs needs to be examined. In the present study two squirrel monkeys were inoculated with mouse PrPsc derived from sheep scrapie, and showed signs of severe spongiform degeneration. These lesions were immunohistochemically characterized as patchy perivacuolar and diffuse synaptic lesions without Congophilic amyloid. The central portion of the assemblies involving a few patchy perivacuolar lesions was detected by methenamine silver staining and appeared as a plaque-like lesion. ApoE was colocalized in all the plaque-like lesions and in half of the patchy perivacuolar lesions, but not in any diffuse synaptic lesions. These immunohistochemical characteristics indicated that apoE colocalization occurred in moderate mature lesions in PDs, and apoE might play an important role in the aggregation of PrPsc after a conformational change from cellular PrP isoform to PrPsc.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 105 (2000), S. 311-320 
    ISSN: 1573-2673
    Keywords: Dynamic crack propagation ; stress intensity factor ; crack velocity ; crack acceleration ; caustic method ; high-speed photography ; PMMA.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Dynamic fracture in PMMA was studied to determine the correlations among dynamic stress intensity factor K ID, crack velocity $$ \dot a $$ and acceleration ä. Specimen geometry, a single-edge-cracked tensile plate with two circular holes, was employed to obtain the crack acceleration, deceleration and re-acceleration process in a single fracture event. K ID was evaluated using the method of caustics in combination with a Cranz-Schardin high-speed camera and correlated with $$ \dot a $$ and ä. The behaviors of K ID $$ \dot a $$ and ä in a SEN specimen were also examined, and the following correlations were obtained: (1) K ID was an increasing function of $$ \dot a $$ , but their relation was not unique. (2) K ID for a constant velocity $$ \dot a $$ was larger when the crack was decelerated than when it was accelerated. (3) K ID was dependent on both $$ \dot a $$ and ä, and K ID for ä=constant could be uniquely related to $$ \dot a $$ .
    Type of Medium: Electronic Resource
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