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  • 2000-2004  (3)
  • Caspase  (1)
  • Korea  (1)
  • Left ventricular volume  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs (2000)
    Springer
    International journal of colorectal disease 15 (2000), S. 105-111 
    Details
    ISSN: 1432-1262
    Keywords: Keywords Nonsteroidal anti-inflammatory drugs ; Colon cancer ; Apoptosis ; Caspase ; Poly(ADP-ribose) polymerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of and mortality from colon cancer. In addition, NSAIDs reduce the number and the size of polyps in patients with familial adenomatous polyposis. The mechanisms responsible for the antineoplastic effect of NSAIDs are not yet completely understood, but one of the possible mechanisms is an induction of apoptosis. We explored the role of caspase-3, a major apoptosis-executing enzyme, in NSAID-induced apoptosis of colon cancer cell line HT-29. Treatment of HT-29 cells with indomethacin induced a dramatic increase in caspase-3-like protease activity measured by a cleavage of the fluorogenic substrate Ac-DEVD-AMC. Western blot analysis showed that indomethacin treatment led both to decrease in pro-caspase-3 and to cleavage of its substrate poly(ADP-ribose) polymerase (PARP). Furthermore, the caspase- 3-like protease inhibitor Ac-DEVD-CHO attenuated indomethacin- induced DNA fragmentation dose dependently. However, mRNA expression of CASP genes was not affected by the addition of indomethacin, highlighting the importance of posttranslational modification of this enzyme for the activation. These results suggest that NSAIDs, including indomethacin, induce apoptosis in colon cancer cells through a caspase-3 dependent mechanism which may contribute to the chemopreventive functions of these agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050242
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Unbiased and efficient estimation of left ventricular volumes by three-dimensional echocardiography with coaxial sections. Validation with magnetic resonance imaging (2000)
    Springer
    Heart and vessels 15 (2000), S. 35-43 
    Details
    ISSN: 1615-2573
    Keywords: Key words Three-dimensional echocardiography ; Magnetic resonance imaging ; Left ventricular volume ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to investigate the degree of bias with coaxial three-dimensional echocardiography in an experimental animal setup and to establish the minimum number of sections needed for estimation of left ventricular (LV) volume. Epicardial coaxial echocardiography and magnetic resonance imaging (MRI) was used to measure LV volume in 14 pigs, with chronic remodeled left ventricles induced by repeated intracoronary microembolizations. In addition, six animals underwent serial MRI at baseline, immediately after intracoronary microembolization, and after 119–165 days (mean 129 days). Coaxial echocardiography was performed by rotational acquisition of long-axis sections starting from an arbitrary angle. Planimetered MRI contours of LV endocardial borders were analyzed to investigate the relationship between the number of coaxial sections, and the precision of volume estimates. The mean ± 2SD of the differences between coaxial epicardial echocardiography with six sections and MRI were −2.5 ± 16.4 ml, 0.8 ± 13. 1 ml, and 2% ± 14% for end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF), respectively. Numerical analysis conducted on MRI contours of LV endocardial borders showed that with six coaxial sections the average coeffi-cient of error was 〈1% for the EDV and ESV. Three-dimensional echocardiography with six coaxial sections provides unbiased LV volume estimation with minimal geometric error.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007260
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Bdelloid rotifers from Korea (2000)
    Springer
    Hydrobiologia 439 (2000), S. 91-101 
    Details
    ISSN: 1573-5117
    Keywords: Rotifera ; Bdelloidea ; Korea ; taxonomy ; biogeography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Twenty-five samples from 18 terrestrial and/or freshwater habitats in the eastern part of Korea yielded 38 new records of bdelloid rotifers, 22 of which are new to the Asian fauna. Among these Korean new records, Dissotrocha aculeata reversa Berzins and Habrotrocha plana Milne were recorded outside their type localities for the first time, and Macrotrachela bullata (Murray) was reported only from two countries after its description. Bradyscela granulosa de Koning, Habrotrocha gracilis gracilis Montet, Macrotrachela latior Donner, Philodina duplicalcar (de Koning) and P. rugosa coriacea Bryce are recorded outside Europe for the first time. The taxonomy and distribution of these rare species are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004181414535
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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