ISSN:
1439-7609
Keywords:
Key words B lymphocytes
;
Single-strand conformational polymorphism
;
Sjögren's syndrome
;
Immunoglobulin variable region
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We encountered a patient with Sjögren's syndrome (SS) associated with bilateral parotid salivary gland swelling. Histological analysis of biopsy specimens from both parotid glands showed myoepithelial islands and infiltration of small- and intermediate-sized lymphocytes but no cytological atypia. Using reverse transcriptase-polymerase chain reaction and subsequent single-strand conformational polymorphism analysis, monoclonal B-cell expansion was detected in samples from both right and left parotid glands, bone marrow, and peripheral blood (PB). Our case suggests that the circulating clonal lymphocytes represent clones that can repopulate tissue sites and may contribute to B-cell lymphomagenesis. Detection of monoclonal B cells in PB is therefore considered to be important in monitoring the disease course of SS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s101650070041
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