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Helicobacter pylori eradication in children and adolescents by a once daily 6-day treatment with or without a proton pump inhibitor in a double-blind randomized trial (2004)

Tindberg, Y. ; Casswall, T. H. ; Blennow, M. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Alimentary pharmacology & therapeutics 20 (2004), S. 0

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ISSN: 1365-2036

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Aim : To evaluate two simplified Helicobacter pylori eradication treatment alternatives for children and adolescents.Methods : Study subjects were identified by enzyme-linked immunosorbent assay and immunoblot in a family screening project. Helicobacter pylori infected 10–21 year olds were offered treatment, individuals with abdominal pain underwent upper endoscopy and those with peptic ulcers were excluded. Participants were randomized to either azithromycin 500 mg daily and tinidazole 500 mg two tablets daily in combination with lansoprasole 30 mg daily for 6 days (ATL-group) or with placebo (ATP-group). Urea Breath Test was performed at inclusion and after a minimum of 6 weeks after end of therapy.Results : In total, 131 individuals were randomized, of whom 31 (24%) had undergone upper endoscopy. Full compliance was achieved in 93% (122 of 131). The intention-to-treat eradication rate was 67% (44 of 66) and 58% (38 of 65) for the ATL- and the ATP-group, respectively.Conclusion : The double-blind randomized clinical trial did not identify a simplified, successful once daily H. pylori treatment for children and adolescents. Thus, twice daily proton pump inhibitor (PPI)-based triple therapies for 7 days remain as the choice of treatment in children. Further, powerful and controlled studies are needed to elucidate the best treatment strategies for H. pylori eradication in this age group.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02077.x

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Stiffness of spruce wood – Influence of moisture conditions (2000)

Bengtsson, C.

Springer

Holz als Roh- und Werkstoff 58 (2000), S. 344-352

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ISSN: 1436-736X

Source: Springer Online Journal Archives 1860-2000

Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: 3 , from Norway Spruce are presented. The measurements were carried out using a dynamic test method at equilibrium moisture content in 30% and 90% relative humidity. The test material, from two stands, was well defined with respect to growth conditions, material properties as knots and compression wood and position in the tree. Large variations in dynamic modulus of elasticity between the two moisture levels were found. For specimens from some trees, these variations were extremely large. The variations were not systematic within each tree as many other wood parameters. A part of the variations was explained by occurrence of compression wood and knots. A strong individual variation in stiffness between different trees was found. To achieve a more fundamental understanding of the relationships between stiffness and moisture content it appeared that also microscopic characteristics need to be taken into account.