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  • 1
    Electronic Resource
    Electronic Resource
    Extending low-dose epidural analgesia for emergency Caesarean section using ropivacaine 0.75% (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We compared ropivacaine 0.75% and bupivacaine 0.5% for extending low-dose epidural analgesia for emergency Caesarean section, using a prospective double-blind randomised controlled trial design. The trial was halted after 45 patients were studied (23 ropivacaine; 22 bupivacaine) because bupivacaine was replaced by levobupivacaine in our unit. Time to reach T4 for loss of cold sensation was similar in both groups, although analgesic supplementation was required less often in the ropivacaine group than in the bupivacaine group (2/23 vs. 9/21; p = 0.01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03753.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A comparison of the intubating and standard laryngeal mask airways for airway management by inexperienced personnel (2001)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 56 (2001), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-four inexperienced participants were timed inserting the intubating laryngeal mask airway and the laryngeal mask airway in 75 anaesthetised subjects. Adequacy of ventilation was assessed on a three-point scale. The pressure at which a leak first developed around the device's cuff was also measured. There was no significant difference in insertion time or the likelihood of achieving adequate ventilation between devices. However, the intubating laryngeal mask airway was better at providing adequate ventilation without audible leak (58/75 (77%) vs. 42/75 (56%); p = 0.009). The median (range [IQR]) pressure at which an audible leak developed was higher for the intubating laryngeal mask airway, 34.5 (14–40 [29–40]) cmH2O, than for the laryngeal mask airway, 27.5 (14–40 [22–33]) cmH2O (p 〈 0.001). The intubating laryngeal mask airway is worthy of further consideration as a tool for emergency airway management for inexperienced personnel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2001.01708-3.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Modelling of load interaction and overload effect on fatigue damage of steel bridges (2001)
    Oxford, UK : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 24 (2001), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper studies the effects of load sequence and interaction, and overloading effect on the fatigue damage of bridges on the basis of a non-linear fatigue damage model. The model is derived from the theory of continuum damage mechanics for high-cycle fatigue. Fatigue behaviour at two levels of constant stress range is first discussed in detail. The formulation for the effective fatigue strength of the predamaged members is then derived, and the results predicted by the model are compared with the experimental data for two stress level tests and other results obtained from linear and double linear fatigue damage models. The variation of cycle ratio and fatigue life due to overloading is secondly investigated; the equations for evaluating the effect of overloading on fatigue damage accumulation on bridges at normal traffic loading are then derived. It has been demonstrated that the developed model can well describe the effect of load sequence and interaction and has also been verified by comparing the predicted results obtained by the model with the experimental data based on two levels of stress tests. The effect of accidental overloading on the fatigue damage of existing bridges can also be evaluated using the model. The model is applied to evaluate the fatigue damage and service life of the Tsing Ma Bridge, an essential portion of the transport network for the Hong Kong airport, under normal traffic loading and possible accidental overloading.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-2695.2001.00396.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Arthritis treatment in Hong Kong — cost analysis of celecoxib versus conventional NSAIDS, with or without gastroprotective agents (2002)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Selective cyclo-oxygenase-2 inhibitors have been reported to cause fewer gastrointestinal complications when compared with conventional, non-selective, non-steroidal anti-inflammatory drugs (NSAIDs).Aim : To analyse the cost of celecoxib (selective cyclo-oxygenase-2 inhibitor) and conventional NSAID regimens for the treatment of osteoarthritis and rheumatoid arthritis from the perspective of a public health organization in Hong Kong.Methods : A decision tree was used to analyse the cost of celecoxib, NSAID alone, NSAID plus histamine2-receptor antagonist, NSAID plus misoprostol and NSAID plus proton pump inhibitor over 6 months. Model outcomes were no gastrointestinal toxicity, gastrointestinal discomfort, symptomatic ulcer, anaemia with occult bleeding and serious gastrointestinal complications. The clinical probabilities were estimated from clinical trials. Resource utilization for gastrointestinal events was determined locally. Sensitivity analysis was performed.Results : The 6-month costs per base-case analysis were as follows: NSAID plus histamine2-receptor antagonist, HK$1404 (1US$=7.8HK$); celecoxib, HK$1545; NSAID alone, HK$1610; NSAID plus misoprostol, HK$2213; NSAID plus proton pump inhibitor, HK$2857. The model was sensitive to the patients' underlying gastrointestinal risk scores, daily cost of NSAID regimen, risk ratio of NSAID plus histamine2-receptor antagonist for symptomatic ulcer, daily cost of celecoxib and daily cost of histamine2-receptor antagonist.Conclusions : Celecoxib appeared to be the least costly alternative in patients with intermediate to high gastrointestinal risk for the treatment of osteoarthritis and rheumatoid arthritis in Hong Kong.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01376.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 45 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01958.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Development of the embryonic kidney (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 1-10 
    Details
    ISSN: 1437-7799
    Keywords: Key words Kidney ; Pronephros ; Mesonephros ; Metanephros ; Nephron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The kidney is a favorite subject of developmental biologists. In the past decade, we have gained a great deal of knowledge about the regulation of kidney development. This review describes the organization of the kidney, the molecules involved in the regulation of kidney development, and a unique protocol for kidney culture. The pronephros, mesonephros, and metanephros represent three distinct renal organs which function, in succession, as the vertebrate excretory system.1 All three such kidneys are derived from the intermediate mesoderm and develop in a well defined temporal and spatial sequence. The pronephros, which consists of a tubule and excretory organ, is established earliest and functions as the simplest of the excretory organs in vertebrates. The amphibian pronephros, a simple organ which provides renal function in the early embryo, is conceptualized in the present study as a model system for devising experimental strategies for the in-vitro cultivation of donor organs and tissues for subsequent transplantation into vertebrate hosts. Combined activin and retinoic acid treatment of blastula-stage ectoderm cultured for 3 days yielded a pronephros-like structure. Its functional capacity was confirmed by transplanting it into late neurula-stage host embryos from which the natural pronephros rudiments had been removed. The donor tissue differentiated into a pronephros-like structure, and the host embryos were able to suppress the edema ordinarily caused by removal of the natural pronephric rudiments. Thus, this provides a model system for analyzing the experimental conditions and relevant principles for the cultivation of functional vertebrate organs for transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050054
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Vitamin D Deficiency and Susceptibility to Tuberculosis (2000)
    Springer
    Calcified tissue international 66 (2000), S. 476-478 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Tuberculosis — Vitamin D — Macrophage — Elderly — Uremia — Asians.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Vitamin D, a modulator of macrophage function, can activate human anti-mycobacterial activity. Vitamin D deficiency is therefore associated with a higher risk of tuberculosis (TB) infection, as indicated by several observations. First, TB tends to occur during the colder seasons when cutaneous synthesis of vitamin D from sun exposure is reduced and serum vitamin D levels are lower. Second, patients with untreated TB, particularly those from a temperate climate, have lower serum vitamin D levels than healthy subjects. Third, the incidence of TB is higher among subjects with relatively low serum vitamin D levels, such as the elderly, uremic patients, and Asian immigrants in the U.K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230010095
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