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  • 2000-2004  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 5 (2000), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Based on the hypothesis that β-carbolines are involved in the pathogenesis of alcohol-related mood disturbance, harman and norharman levels were assayed in the blood plasma of alcoholics and correlated to the Hamilton Depression (HAM-D) scores after 3 and 5 weeks post-admission. Tobacco smoking was co-evaluated since it is known to influence β-carboline levels. After a 3-week period, plasma harman but not norharman was increased in depressed alcoholics and positively related to the HAM-D sum-score (r = 0.47; p 〈 0.04) and to tobacco smoking (r = 0.56; p 〈 0.02). Since no correlation between depression and smoking was found, these data could account for the higher incidence of depressive symptoms in withdrawn alcoholics with increased harman levels. The partial correlations support this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1369-1600.2000.tb00213.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Assay of salsolinol in peripheral blood mononuclear cells of alcoholics and healthy subjects by gas chromatography-mass spectrometry (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 7 (2002), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Endogenous 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) could be a potential marker involved in the aetiology of alcoholism.Whereas the amount of salsolinol in plasma and urine depends on several dietary conditions, the salsolinol from peripheral mononuclear cells should be formed endogenously. Salsolinol was quantified in lymphocytes of 10 controls and 11 alcoholics (after 1 and 13 weeks of abstinence) using solid phase extraction and gas chromatography/mass spectrometry. Alcoholics showed significantly lower salsolinol concentration than the controls. After 13 weeks of abstinence a further significant decrease of SAL levels could be seen in the lymphocytes of alcoholics. The findings of this study support the theory that salsolinol might be a trait marker in alcoholism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/1355621021000005991
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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