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  • 1
    Electronic Resource
    Electronic Resource
    A Neurospora crassa Arp1 mutation affecting cytoplasmic dynein and dynactin localization (2000)
    Springer
    Molecular genetics and genomics 264 (2000), S. 433-440 
    Details
    ISSN: 1617-4623
    Keywords: Cytoplasmic dynein Dynactin p150Glued Arp1 Microtubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Of the actin-related proteins, Arp1 is the most similar to conventional actin, and functions solely as a component of the multisubunit complex dynactin. Dynactin has been identified as an activator of the microtubule-associated motor cytoplasmic dynein. The role of Arp1 within dynactin is two-fold: (1) it serves as a structural scaffold protein for other dynactin subunits; and (2) it has been proposed to link dynactin, and thereby dynein, with membranous cargo via interaction with spectrin. Using the filamentous fungus Neurospora crassa, we have identified genes encoding subunits of cytoplasmic dynein and dynactin. In this study, we describe a genetic screen for N. crassa Arp1 (ro-4) mutants that are defective for dynactin function. We report that the ro-4(E8) mutant is unusual in that it shows alterations in the localization of cytoplasmic dynein and dynactin and in microtubule organization. In the mutant, dynein/dynactin complexes co-localize with bundled microtubules at hyphal tips. Given that dynein transports membranous cargo from hyphal tips to distal regions, the cytoplasmic dynein and dynactin complexes that accumulate along microtubule tracts at hyphal tips in the ro-4(E8) mutant may have either reduced motor activity or be delayed for activation of motor activity following cargo binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380000304
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  • 2
    Electronic Resource
    Electronic Resource
    Structural Development During Thermal Fractionation of Polyethylenes (2000)
    Springer
    Journal of thermal analysis and calorimetry 59 (2000), S. 245-255 
    Details
    ISSN: 1572-8943
    Keywords: DSC ; metallocene ; polyethylenes ; SAXS ; synchrotron radiation ; thermal fractionation ; WAXD ; Ziegler-Natta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In this study, the stepwise isothermal crystallization or thermal fractionation of Ziegler—Natta and metallocene based polyethylenes (ZN-PE and m-PE) with two kinds of branch lengths (ethyl and hexyl) and branch compositions were studied using simultaneous synchrotron small-angle X-ray scattering (SAXS)/wide-angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC). The crystal long period and the invariant were determined by SAXS, and the variations of crystal unit cell parameters and the degree of crystallinity were determined by WAXD. The arithmetic mean length (Ln), the weightedmean length (Lw) and the broadness index (Lw/Ln) of the studied polyethylenes were previously determined by DSC. Results from these studies were interpreted using the model of branch exclusion, which affects the ability of the chain-reentry into the crystal phase. Multiple SAXS peaks and step-change in crystallinity change (WAXD) were seen during heating, which corresponded well with the crystal thickness distribution induced by stepwise crystallization. The effects of the heterogeneity of the 1-olefin branch length and the distribution on the crystal long period and the invariant as well as the degree of crystallinity were discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010100432613
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Wegener’s Granulomatosis Presenting as Mediastinal Soft Tissue Mass Invading the Tracheal Wall (2000)
    Springer
    Clinical rheumatology 19 (2000), S. 495-498 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Mediastinal mass – Tracheal invasion – Wegener’s granulomatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Wegener’s granulomatosis (WG) is a clinicopathologic entity of unknown cause characterised by a necrotising granulomatous vasculitis affecting multiple organs, especially the upper and lower respiratory tracts, lung and kidney. The lung is the most frequently, and sometimes the only involved organ. Single or multiple nodules, with or without cavitation, are the most common pulmonary manifestations in WG, but mediastinal involvement is atypical. The sole tracheal involvement is rare and hilar and mediastinal involvement has been thought not to be part of the clinical feature. We experienced a rare case of WG presenting as paratracheal mediastinal lesions with tracheal wall invasion, which responded dramatically to corticosteroid treatment. We present this case with a review of the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670070016
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    Paper (German National Licenses)
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