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  • 2000-2004  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Effective doses of vecuronium in a patient with myotonic dystrophy (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Of the forms of muscular dystrophy, myotonic dystrophy has the greatest systemic involvement. Although most patients with myotonic dystrophy show normal sensitivity to non-depolarising neuromuscular blocking drugs, some have been reported to show greatly increased sensitivity to these drugs, and little is known about the sensitivity of different muscles. We compared effective doses of vecuronium in a patient with myotonic dystrophy at the orbicularis oculi, adductor pollicis and flexor hallucis brevis muscles during total intravenous anaesthesia. The calculated ED50 for the orbicularis oculi (7.77 μg.kg−1 (95% CI 3.10–16.8 μg.kg−1)) was lower than for the adductor pollicis (25.3 μg.kg−1 (95% CI 20.7–43.3 μg.kg−1)) and flexor hallucis brevis muscles (29.5 μg.kg−1 (95% CI 11.0–85.6 μg.kg−1; p 〈 0.01)). The ED90 was also lower for the orbicularis oculi (35.7 μg.kg−1 (95% CI 14.8–66.5 μg.kg−1)) than for the other muscles (51.8 μg.kg−1 (95% CI 29.3–145.0 μg.kg−1) and 50.6 μg.kg−1 (95% CI 5.29–642.0 μg.kg−1), respectively) (p 〈 0.01)).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03926.x
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  • 2
    Electronic Resource
    Electronic Resource
    Serotonergic Neurones in the Dorsal Raphe Nucleus That Project into the Medial Preoptic Area Contain Oestrogen Receptor β (2001)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neuroendocrinology 13 (2001), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serotonin is involved in female sexual behaviour in which the medial preoptic area (MPA) has a pivotal role. The present study used immunohistochemistry, in situ hybridization and retrograde transport analysis to investigate whether serotonin neurones in the dorsal raphe nucleus (DRN) of females projecting into the MPA contained oestrogen receptor α or β. The projection of serotonin neurones from the DRN to the MPA was confirmed using the microinjection of Fluoro-Gold (FG), a fluorescent retrograde tracer, into the MPA of ovariectomized (OVX-group) and OVX-rats treated with oestradiol benzoate (E2-group). A number of serotonin neurones in the DRN were labelled with FG, indicating that these serotonin neurones in DRN project their terminals into the MPA. FG-labelled serotonin neurones expressed ERβ mRNA in the DRN, and the number of the serotonin neurones containing ERβ mRNA between the OVX-group and the E2-treated group was not significantly different. Serotonin neurones in the DRN did not express ERα-immunoreactivity. Since previous findings showed that the density of serotonin-immunoreactive fibres and the concentration of serotonin within the MPA was significantly lower in the E2-group than the OVX-group, our present observations suggested that the regulatory effects of E2 on the serotonergic neurone system in the MPA may be via ERβ within the serotonin-containing cells in the DRN of female rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.2001.00695.x
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    Paper (German National Licenses)
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