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  • 1
    Electronic Resource
    Electronic Resource
    Histoclinical Analysis of Early Colorectal Cancer (2000)
    Springer
    World journal of surgery 24 (2000), S. 1029-1035 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the clinicopathologic characteristics of early colorectal cancer (ECC), histopathologic and clinical features of 90 ECC patients who underwent surgical resection (not including the endoscopic polypectomized cases) and 1704 patients with advanced colorectal cancer were analyzed. Smaller size, better histologic differentiation, less lymph node (LN) metastasis, and better clinical outcome were observed in those with ECC than in patients with more advanced lesions. LN metastasis was found in 5 patients with ECC among the 56 patients who underwent bowel resection (8.9%). Tumors with LN metastasis were more frequently associated with deep submucosal invasion, absence of an adenomatous component within the tumor, sessile configuration, and lymphovascular invasion. Tumors showing deep submucosal layer invasion were associated with a more unfavorable histologic grade, lymphovascular invasion, LN metastasis, sessile morphology, and absence of an adenomatous component within the tumor. Recurrence was observed in two patients who underwent local excision for their submucosal cancer. One of the patients was salvaged after bowel resection, but one patient died of distant metastasis. From our data analysis and literature review, extensive submucosal invasion, lymphovascular invasion, sessile configuration, and tumors with no adenomatous component should be considered high risk factors for LN metastasis and recurrence after limited therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002680010143
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  • 2
    Electronic Resource
    Electronic Resource
    Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 26 (2000), S. 16-17 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Aberrant promoter methylation and the associated loss of gene expression is a common accompaniment of human cancers. Nonetheless, it has been challenging to demonstrate in any given tumour that methylation of a specific gene was causal and not consequent to malignant transformation. In this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/79120
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  • 3
    Electronic Resource
    Electronic Resource
    Long-term clinical course and prognostic factors in intestinal Behçet's Disease (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 692-700 
    Details
    ISSN: 1530-0358
    Keywords: Behçet's Disease ; Intestinal disease ; Reoperation ; Recurrence ; Azathioprine ; Intestinal perforation ; Hemicolectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The present study was aimed at evaluating the long-term course of intestinal Behçet's disease and determining predictive factors of prognosis. METHODS: This report is a retrospective study based on the records of 43 patients with intestinal Behçet's disease. The mean follow-up duration was 73±60 months. We evaluated the efficacy of medical treatment for the intestinal lesion at initial eight weeks. The cumulative probabilities were calculated by using Kaplan-Meier method, and the results were compared by using the log-rank test. RESULTS: Sixteen patients (38 percent) achieved a complete remission of intestinal lesions eight weeks after medical treatment had begun. The patients who achieved a complete remission had a lower probability of receiving an operation than those who had not (13 percent at 2 and 5 yearsvs. 36 and 43 percent, respectively;P=0.028). The recurrence probability of intestinal lesions was 25 percent at two years and 49 percent at five years after complete remission with medical treatment. Patients who had a history of intestinal perforation or fistula had a higher probability of recurrence after operation than those without such history (59vs. 33 percent at 2 years; 88vs. 57 percent at 5 years;P=0.020). Patients who had taken azathioprine had a lower probability of receiving reoperation than those who did not (7vs. 25 percent at 2 years; 25vs. 47 percent at 5 years;P=0.035). The length of ileal resection and whether hemicolectomy was performed had no significant effect on the recurrence or reoperation rate. CONCLUSIONS: Intestinal Behçet's disease frequently requires a surgical treatment and has a high recurrence rate. The patients who achieved a complete remission with medical treatment, who had no history of intestinal performation, and who received azathioprine after operation showed better clinical courses. Resection of a short segment of bowel would be a more appropriate surgical procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02235590
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    Paper (German National Licenses)
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