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  • 1
    Electronic Resource
    Electronic Resource
    S100-β serum protein—a new marker in the diagnosis and monitoring of Langerhans cell histiocytosis? (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03622.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Topical imiquimod eradicates skin metastases of malignant melanoma but fails to prevent rapid lymphogenous metastatic spread (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.488811.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Melanoma-associated retinopathy: high frequency of subclinical findings in patients with melanoma (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome with symptoms of night blindness, light sensations, visual loss, defect in visual fields, and reduced b-waves in the electroretinogram. Patients with MAR often suffer from a sudden onset of ocular symptoms that are believed to result from antibody production against melanoma-associated antigens that cross-react with corresponding epitopes on retinal depolarizing bipolar cells. Objectives To correlate the frequency of subclinical symptoms suggestive of MAR in melanoma patients to different stages of disease, patient age, type and thickness of the primary tumour, form of therapy, S-100 level and tumour burden. Methods We analysed 28 patients with melanoma in stages I–IV (according to the American Joint Committee on Cancer tumour classification) for the presence of subclinical MAR symptoms using scotopic electroretinography, static and kinetic perimetry and nyctometry. Results Seven patients had clinical signs and symptoms consistent with MAR, 18 had some indications, while the remaining three had none. We found no correlation between clinical symptoms and stage of disease, tumour burden or S-100 level, but findings suggestive of MAR were observed more frequently in advanced stages of disease. Conclusions Subclinical retinal involvement characteristic of MAR appears to be more common than previously suspected in patients with cutaneous malignant melanoma. Our findings in this small cohort seem to indicate that the percentage of patients with symptoms suggestive of MAR is higher in advanced stages of disease. Further clinical studies are required to evaluate if the presence of subclinical symptoms suggestive of MAR is correlated with a worse prognosis and a shortened progression-free and overall survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05377.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hochdosis-Steroid-Pulstherapie Gibt es Indikationen in der Dermatologie? (2000)
    Springer
    Der Hautarzt 51 (2000), S. 738-745 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Hochdosis-Steroid-Pulstherapie ; Pharmakologische Grundlagen ; Wirkmechanismen ; Dermatologische Indikationen ; Keywords High-dose steroid puls therapy ; Pharmacological basics ; Mechanisms of action ; Dermatological indications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In recent years, high-dose steroid pulse therapy has been considered an effective treatment regimen in a number of non-dermatological diseases. This review addresses in the first part the pharmacological basics and mechanisms of action of high-dose glucocorticosteroid therapy. In the second part, we discuss the clinical experience using this treatment for dermatological diseases including pemphigus vulgaris, pyoderma gangrenosum, alopecia areata, and derma-tomyositis.
    Notes: Zusammenfassung Das krankheitsspezifische Indikationsspektrum für eine Stoßtherapie mit hochdosierten Glukokortikoiden ist in den letzten Jahren erheblich erweitert worden. Im ersten Teil der folgenden Übersicht wird der aktuelle Kenntnisstand zu den pharmakologischen Grundlagen und Wirkmechanismen der Hochdosistherapie mit Glukokortikoiden vorgestellt. Im Anschluss werden die vorliegenden klinischen Erfahrungen zur Anwendung dieser Therapie bei verschiedenen dermatologischen Indikationen wie Pemphigus vulgaris, Pyoderma gangraenosum, Alopecia areata, Dermatomyositis und anderen Dermatosen besprochen und kritisch bewertet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051207
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    Paper (German National Licenses)
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