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  • 1
    Electronic Resource
    Electronic Resource
    Study of interaction between hypochlorite anion and unilamellar phosphatidylcholine liposomes by UV absorption spectroscopy (2000)
    Springer
    Bulletin of experimental biology and medicine 129 (2000), S. 244-246 
    Details
    ISSN: 1573-8221
    Keywords: hypochlorite anion ; hypochlorous acid ; chloric acid ; phosphatidylcholine liposomes ; conjugated dienes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Absorption of conjugated dienes from autoxidized unilamellar phosphatidylcholine liposomes in 145 mM NaCl and 10 mM Na+,K+-phosphate buffer (pH 7.0) decreased only snap increase in the concentration of HOCl/ClO− (pH 7.0) to 80 μM or more. Absorption of low-reactivity HO2Cl/ClO 2 − increased during stepwise addition of HOCl/ClO− into the suspension to a lower final concentration (below 30 μM). These results can be explained by limited permeation of hydrophilic HOCl/ClO− into the phospholipid bilayer, ion-ion interaction of ClO− with positively charged phosphatidylcholine heads, and catalysis of the following reaction: 2(HOCl/ClO−)→HO2Cl/ClO 2 − .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433895
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oxidative stress in keratinocytes as an etiopathogenetic factor of psoriasis (2000)
    Springer
    Bulletin of experimental biology and medicine 129 (2000), S. 309-313 
    Details
    ISSN: 1573-8221
    Keywords: psoriasis ; apoptosis ; inflammation ; proliferation ; oxidative stress ; lipid peroxidation ; reactive oxygen species ; redox potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A new etiopathogenetic concept of psoriasis is proposed, which considers psoriasis as a typical inflammatory process characterized by increased antioxidant activity and overexpression of apoptotic receptors. Under these conditions, hyperstimulation of germinative layer cells proliferation dramatically accelerates kerationcyte passage towards apoptotic effect of atmospheric oxygen and its reactive species dooming to death cells with enhanced expression of apoptotic receptors. Oxidative stress of nondifferentiated kerationcytes triggers the formation of defective horny layer, the key mechanism of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02439252
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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