ISSN:
1573-8221
Keywords:
psoriasis
;
apoptosis
;
inflammation
;
proliferation
;
oxidative stress
;
lipid peroxidation
;
reactive oxygen species
;
redox potential
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract A new etiopathogenetic concept of psoriasis is proposed, which considers psoriasis as a typical inflammatory process characterized by increased antioxidant activity and overexpression of apoptotic receptors. Under these conditions, hyperstimulation of germinative layer cells proliferation dramatically accelerates kerationcyte passage towards apoptotic effect of atmospheric oxygen and its reactive species dooming to death cells with enhanced expression of apoptotic receptors. Oxidative stress of nondifferentiated kerationcytes triggers the formation of defective horny layer, the key mechanism of psoriasis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02439252
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