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  • 1
    Electronic Resource
    Electronic Resource
    Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice (1995)
    Springer
    Inflammation research 44 (1995), S. 491-498 
    Details
    ISSN: 1420-908X
    Keywords: MRL/lpr.Yaa mice ; Autoimmune disease ; Lymphokine ; Cyclophosphamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Y chromosome (Yaa gene) from autoimmune BXSB mice has been shown to be responsible for the acceleration of autoimmune symptoms when transferred to MRL/lpr mice. We examined the pathological, serological and immunological characteristics of MRL/lpr.Yaa mice and the suppressive effect of cyclophosphamide (CP) on the mice. MRL/lpr.Yaa mice spontaneously developed a massive lymphadenopathy characterized by hypergammaglobulinemia, the presence of several autoantibodies, and autoimmune disease. In MRL/lpr.Yaa mice, IL-2, IL-4 and IL-5 production in concanavalin A (Con A)-stimulated splenocytes were about 10-fold lower than in BALB/c mice at 5 weeks of age.The concentrations of these lymphokines remained low until the mice were 16 weeks of age. The production of IFN-γ and IL-6 in 16 week old MRL/lpr.Yaa mice was about 4- and 2-fold lower, respectively, though these levels were similar in both strains at 8 weeks of age. It was found that this dysregulation of T cell function was almost identical to that in MRL/lpr mice. Administration of CP to MRL/lpr.Yaa mice ameliorated nephritis, and suppressed production of autoantibodies and the accumulation of abnormal T cells. CP also significantly elevated the production of lymphokines. These findings suggest that an abnormality of T cell function may contribute to the autoimmune pathogenesis of MRL/lpr.Yaa mice and that CP probably ameliorates autoimmune disease by improving the T cell functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01837916
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of mesoporphyrin on experimental arthritis in mice (1996)
    Springer
    Inflammation research 45 (1996), S. 293-298 
    Details
    ISSN: 1420-908X
    Keywords: Mesoporphyrin ; T cell ; Collagen-induced arthritis ; Superantigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of mesoporphyrin, a novel porphyrin derivative, on type II collagen-induced arthritis in mice were studied. Mesoporphyrin (10–30 mg/kg) and prednisolone (5 mg/kg; reference drug) reduced the incidence and severity of type II collagen-induced arthritis in mice, as assayed by clinical observation and histopathological studies. Although both agents inhibited type II collagen-induced delayed type hypersensitivity in arthritic mice, only prednisolone inhibited humoral immunity to type II collagen. The effects of mesoporphyrin on T cell dependent allergic inflammation were examined, in order to study the mechanism by which it inhibits arthritis. Staphylococcal enterotoxin B (SEB; superantigen)-potentiated collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity reaction were clearly inhibited by mesoporphyrin. Moreover, the superantigen-induced CD-25 expression on T cells was inhibited by mesoporphyrin. These results indicate that mesoporphyrin inhibits type II collagen-induced arthritis by inhibiting the activation of T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02280994
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Development of a database system for the thermophysical properties of 340 pure fluids (1983)
    Springer
    International journal of thermophysics 4 (1983), S. 283-294 
    Details
    ISSN: 1572-9567
    Keywords: compressibility factor ; database system: density ; dielectric constant ; refractive index ; retrieval program ; specific enthalpy ; specific entropy ; specific heat capacity ; specific volume ; surface tension ; thermal conductivity ; vapor pressure ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new database system was designed and constructed in order to provide the newest and most reliable numerical data on thermophysical properties of fluids to the scientific and technical community as quickly as possible. The database is concerned with 12 kinds of property data: density, specific volume, compressibility factor, vapor pressure, specific heat, specific enthalpy, specific entropy, viscosity, thermal conductivity, surface tension, refractive index, and dielectric constant of 340 pure fluids under all conditions of seven convenient physical states. Only the most probable data, which were critically evaluated in advance, are compiled as functions of temperature and pressure in the form of either numerical data tables or correlation formulas. Property values at desired grid points of temperature and pressure can be obtained in SI units directly or by interpolations with some supplementary information, such as the grade of reliability, source bibliography, and fundamental physical constants of the fluid. The database is usable as conversational processing by TSS, the tabulation of property data in a batch processing, and one of the subroutine libraries in the computation of a user's program. Ten kinds of application programs are prepared for multipurpose retrievals so that anyone can use the database without any special knowledge of the structure or machine languages of this system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01178780
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  • 4
    Electronic Resource
    Electronic Resource
    S1.27 Synthesis of inhibitor forN-Acetylglucosaminyltransferase V (1993)
    Springer
    Glycoconjugate journal 10 (1993), S. 228-228 
    Details
    ISSN: 1573-4986
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209828
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    Paper (German National Licenses)
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