Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1995-1999  (2)
  • 1990-1994  (9)
  • 1975-1979  (3)
  • 1960-1964  (3)
  • Chemistry  (14)
  • crystal structure  (5)
  • Cell & Developmental Biology  (3)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Colchicine-induced stimulation of PMN motility related to cytoskeletal changes in actin, α-actinin, and myosin (1993)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 25 (1993), S. 10-18 
    Details
    ISSN: 0886-1544
    Keywords: microtubules ; blebs ; locomotion ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Colchicine-induced stimulation of polymorphonuclear leukocyte (PMN) locomotion is an interesting model because extension of blebs at the front occurs at a rate (about 2.4 μm/s) which is far above that reported for growth of actin filaments. The following cytoskeletal changes were observed in colchicine-treated PMNs: (1)a small increase in cytoskeleton-associated actin was noted, as well as a somewhate more pronounced increase in cytoskeleton-associated α-actinin, as compared with untreated or DMSO-treated controls. There was, however, no measurable increase in F-actin as determined by NBD-phallacidin blinding; (2)the values for the ratio (α-actinin/actin) are lower in PMNs treated with colchicine for 30 min, as compared with PMNs stimulated with fNLPNTL for 1 minute (non-polar ruffling cells) or 30 min (polarized locomoting cells); thus, this ratio may depend on the type of PMN motility; (3) in polarized PMNs F-actin was mainly located linearly all along the cell membrane; there was more intense staining at the front of the cells; (4) α-actining appeared to colocalize with F-actin at the leading front, but not with F-actin at the tail of polarized cells; (5) myosin was preferentially found at the rear part of polarized cells but not or only to a small extent at the front. Our data indicate a close functional correlation between microtubules and microfilaments. We speculate that F-actin in combination with α-actinin promotes expansion of pseudopods, whereas myosin combined with F-actin promotes contraction. In more general terms we suggest that different forms of PMN motility are generated by differential selective interaction of cytoskeletal compnents and variations in the composition of the cytoskeleton in different sites of the same cells. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970250103
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Modified monoclonal antibody production kinetics kappa/gamma mRNA levels, and metabolic activities in a murine hybridoma selected by continuous Culture (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 44 (1994), S. 753-764 
    Details
    ISSN: 0006-3592
    Keywords: hybridoma ; subclone ; continuous culture ; batch culture ; igG-mRNA ; biosynthetic activities ; antibody production ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: During long-term continuous culture of the hybridoma cell line 11317, a better-producing subclone (I1317-SF11), giving improved productivity, has been selected. The comparison of the original cell line (I1317-DC) with this subclone revealed that although the growth patterns of both clones were similar, both in continuous and in batch cultures, considerable differences could be seen between the clones with respect to monoclonal antibody (MAB) accumulation, MAB production rate, the levels of mRNA coding for heavy and light chains of IgG, and some metabolic activities. In continuous culture as well as in batch culture, I1317-SF11 showed increased levels of mRNA coding for kappa and gamma chains compared with I1317-DC and/or a modified ratio of the mRNA species when compared to that in I1317-DC. Using pulse experiments, it could be established that the biosynthesis of both chains was augmented in I1317-SF11. Although the kappa and gamma mRNA levels were modified or inversed for I1317-SF11, the cells always synthesized more kappa than gamma chains. The overall increase in the synthetic activity of I1317-SF11 is suggested as one reason for the considerable increase of IgG productivity and product accumulation in continuous culture as well as in repeated batch cultures. Tests concerning metabolic activity revealed that I1317-SF11 had a predominantly glycolytic metabolism independent of growth requirements, whereas for I1317-DC the metabolism became increasingly glycolytic with increased growth. The antibody yield coefficient of I1317-SF11 on glutamine was significantly higher than that of I1317-DC for the continuous culture, whereas the antibody coefficients on glucose were almost similar for both clones under the different culture conditions used. Both antibody coefficients were considerablly influenced by the specific growth rate.All these facts together lead to the conclusion that subclone I1317-SF11 uses more of the energy available, or it was the energy and/or precursors available for the synthesis and production of MAB more efficiently than the thesis and production of MAB more efficiently than the original cell line. Although the levels of mRNA coding for heavy and light chains of IgG were modified, it could be confirmed that the overall regulation of MAB-synthesis and -production occurs post-translationally and that at higher growth rates, more biosynthetic activity is diverted to biomass production. © 1994 John Wiley & Sons, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260440612
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Bewertung von Oberflächenrissen mit Methoden des plastischen Versagens (1992)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 23 (1992), S. 299-304 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Untersuchungen an Flachzugproben und Behältern aus Vergütungs- und Feinkornbaustählen mit etwa halbelliptischen Oberflächenrissen haben gezeigt. Daß die Versagensspannung nach Verfahren des plastischen Versagens konservativ ermittelt wird. Während sie nach dem Ansatz von Harrison und dem Fließkriterium von Mises - unabhängig von der Rißtiefe - im Mintel um etwa 10% unterschätzt wird, bewerten die anderen untersuchten Verfahren (Mattheck, Chell) deutlich konservativer. Der Grad der Unterschätzung wächst von etwa 30 bzw. 40% bei mittleren Rißtiefen bis zu 70% bei tiefen Rissen. Für einseitigen Wasserstoffangriff auf der Rißausgangsseite ergaben sich i.a. die gleichen konservativen Bewertungen wie bei Luftumgebung.Die Untersuchung hat weiterhin gezeigt, Daß die Versagensspannung von Fluchzugproben unter Luft- und Wasserstoff-Atmosphäre mit etwa konstanter Rißtiefe mit guter Genauigkeit berechnet werden kann, wenn im Restquerschnitt der Mittelwert zwischen Streckgrenze und Zugfestigkeit als Fließspannung angesetzt wird.Es ist für ähnliche Bauteile zu erwarten, daß die erarbeiteten Ergebnisse auf Werkstoffe mit vergleichbaren Rißzähigkeits- und Festigkeitseigenschaften übertragbar sind.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19920230808
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Das Korrosionsverhalten von Titan in Salpetersäure hoher Temperaturen (1964)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 15 (1964), S. 741-743 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: The corrosion resistance of titanium in nitric acid of high temperaturesCorrosion tests showed that, in nitric acid of a concentration ranging from 20 to 70 percent. and at temperatures ranging from 190 to 230° C, titanium has a corrosion rate of between 1 and 10mm pr. annum. This high corrosion rate can be avoided if a substance containing silicon is added to the nitric acid.
    Notes: Korrosionsversuche ergaben, daß Titan in Salpetersäure der Konzentrationen 20 bis 70% bei Temperaturen von 190 bis 230° C rnit Geschwindigkeiten zwischen 1 bis 10 mm/Jhr. abgetragen wird. Diese starke Korrosion läßt sich unterbinden, wenn der Salpetersäure eine siliciumhaltige-Substanz zugesetzt wird.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19640150906
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Enzymatische Transformation chemische gebundener Energie in osmotische Arbeit (1960)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 72 (1960), S. 778-779 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19600722110
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Dosage simultané de la di-iodo-3,5-tyrosine, de la di-iodo-3,5-thyronine et de la thyroxine par nitration suivie d'une réduction polarographique et par détermination colorimétrique de l'iode libéré (1962)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 45 (1962), S. 290-308 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Lorsqu'on traite la di-iodo-3,5-tyrosine, la di-iodo-3,5-thyronine et la thyroxine par HNO3 0,15 M, on observe la formation de plusieurs dérivés nitrés et un dégagement du seul iode en ortho par rapport à la fonction phénolique. Une étude chromatographique et polarographique a permis d'identifier et de déterminer la concentration de la plupart de ces dérivés. La nitration est suffisamment reproductible pour permettre un dosage polarographique. La détermination de l'iode libéré fournit également une donnée pour lé dosage de certains de ces acides aminés. Une séparation est nécessaire pour laquelle un appareillage est proposé qui permet, en une seule opération, de nitrer, de distiller et d'extraire l'iode par le benzène. Le dosage des composés nitrés se fait par polarographie de la solution aqueuse, celui de l'iode dans la phase organique, par colorimétrie. Le comportement de l'iode au cours de la séparation a été étudié au moyen de l'iode 131.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19620450136
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Diacylglycerols and PMA are particularly effective stimulators of fluid pinocytosis in human neutrophils (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 145 (1990), S. 465-471 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Diacylglycerols (OAG, diC8) and PMA were found to stimulate fluid pinocytosis (net uptake of FITC-dextran) to a far greater extent than other neutrophil activators, such as the chemotactic agents fNLPNTL and LTB4, the microtubule disassembling agents colchicine and nocodazole, the kinase inhibitor H-7, or D2O. OAG and diC8 produce a dose-dependent increase in the uptake of FITC-dextran, which is up to about 25- to 30-fold the control value of unstimulated neutrophils. The protein kinase inhibitor H-7 alone had a small stimulating effect on the net uptake, and it failed to inhibit stimulation of fluid pinocytosis by PMA, OAG, and diC8. Also, the protein kinase inhibitor staurosporine failed to inhibit fluid pinocytosis stimulated by OAG, diC8, and PMA. Stimulated fluid pinocytosis and vacuolization in response to PMA or diacylglycerols is associated with surface ruffling of neutrophils. Pinocytosis as well as surface ruffling stimulated by PMA, OAG, diC8, or diC10 are suppressed in the presence of cytochalasin D. The results suggest that diacylglycerols may be instrumental in transducing the signal for stimulated pinocytosis and that the surface movements induced by diacylglycerols, and PMA may be instrumental in fluid pinocytosis.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041450311
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41 251 on PMN locomotion, cell polarity, and pinocytosis (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 161 (1994), S. 526-536 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Using two newly synthesized inhibitors, Ro 31-8220 and CGP 41 251, of protein kinase C (PKC), we analyzed: (1) how distinct PMN functions (shape changes, locomotion, pinocytosis) are regulated, and (2) the role of protein phosphorylation and PKC in this process. We were able to transform: (1) resting PMNs into locomoting cells using fNLPNTL, (2) locomoting cells into non-locomoting highly pinocytic cells using PMA, and (3) PMA-stimulated cells showing marked pinocytosis into locomoting or into resting cells using Ro 31-8220. It is thus possible to selectively manipulate PMN function (resting state, locomotion, marked pinocytosis), indicating that there are different regulatory pathways. It was not possible to induce locomotion and marked pinocytosis simultaneously, indicating crosstalk between pathways. Ro 31-8220 inhibited PMA-induced shape changes (nonpolar cells) and pinocytosis, but not fNLPNTL-induced shape changes (polarity) and pinocytosis. At higher concentrations, Ro 31-8220 alone elicited cell polarity and chemokinesis, indicating that a constitutively active protein kinase is involved in maintaining the spherical shape of resting PMNs. Functional effects of another PKC inhibitor, CGP 41 251, on neutrophil function were strikingly different. CGP 41 251 selectively inhibited fNLPNTL-induced polarity and locomotion (but not colchicine or Ro 31-8220-induced polarity), and it failed to inhibit PMA-induced, stimulated pinocytosis and shape changes. Although the effects of Ro 31-8220 vs. CGP 41 251 on PMN function were strikingly different, the inhibition of profiles for constitutive and for fNLPNTL- or PMA-induced protein phosphorylation in intact PMNs showed only small differences, which could not yet be conclusively related to cell function. © 1994 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041610316
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Trigonal-planare CuX3-Gruppen in Cu2Mo6X14, X = Cl, Br, IProfessor Herbert Jacobs zum 60. Geburtstag gewidmet (1996)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 622 (1996), S. 663-669 
    Details
    ISSN: 0044-2313
    Keywords: Dicopper(I)-octa-μ3-halogeno-hexahalogeno-octahedro-hexamolybdate(II) ; crystal structure ; Mo6X14-group ; trigonal planar CuX3-group ; ionic conduction ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Trigonal Planar CuX3-Groups in Cu2Mo6X14, X = Cl, Br, ICu2Mo6Cl14 (I), Cu2Mo6Br14 (II) and Cu2Mo6I14 (III) were synthesized by thermal treatment of corresponding mixtures of copper(I) and molybdenum(II) halides. The crystal structures were determined by single crystal X-ray analyses. I and II show isotypism, cubic, Pn3 (no. 201, sec. setting), Z = 4, I: a = 12.772(3) Å, II: a = 13.350(2) Å. III shows a new structural type, orthorhombic, Pbca (No. 61), Z = 4, a = 16.058(3) Å, b = 10.643(2) Å, c = 16.963(3) Å. Trigonal planar CuX3 units were found in I—III. Structural behaviour relations are discussed, especially with regard to ionic conductivity.
    Notes: Cu2Mo6Cl14 (I), Cu2Mo6Br14 (II) und Cu2Mo6I14 (III) wurden durch thermische Behandlung der Gemenge der binären Halogenide CuX und Mo6X12 im molaren Verhältnis 2:1 in einkristalliner Form erhalten. Röntgenographische Strukturbestimmung wurde an Einkristallen durchgeführt. I und II zeigen Isotypie, Pn3 (Nr. 201, sec. setting) Z = 4, I: a = 12,772(3) Å, II: a = 13,350(2) Å. III weist eigenen Strukturtyp auf: Pbca (Nr. 61), Z = 4, a = 16,058(3) Å, b = 10,643(2) Å, c = 16,963(3) Å. In I—III liegen trigonal planare CuX3-Gruppen vor. Bindungsverhältnisse und Meßergebnisse der Ionenleitfähigkeit werden diskutiert.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19966220415
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Pb2PdX6 (X = Cl, Br) - Verbindungen mit gestreckten [PdX6]-OktaedernProfessor Hanskarl Müller-Buschbaum zum 65. Geburtstage gewidmet (1996)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 622 (1996), S. 1231-1235 
    Details
    ISSN: 0044-2313
    Keywords: Dilead(II)-hexahalogenopalladate(II) ; crystal structure ; strongly elongated PdX6 octahedra ; DTA, IR/RAMAN, 207Pb MAS NMR ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Pb2PdX6 (X = Cl, Br) - Compounds with Elongated [PdX6] OctahedraIn contradiction to published data new compounds in the systems PbX2 - PdX2 (X = Cl, Br) with the formula Pb2PdCl6 (I) and Pb2PdBr6 (II) were found. These were synthesized by thermal treatment of the corresponding mixtures of PbX2 and PdX2 (X = Cl, Br). X-ray single crystal structure analysis shows isotypism of I and II, monoclinic, P21/c (No. 14), Z = 2, I: a = 9.037(2) Å, b = 6.224(1) Å, c = 8.162(1) Å, β = 90.31(7)β, II: a = 9.512(7) Å, b = 6.584(8) Å, c = 8.383(3) Å, β = 90.07(5)º. Strongly elongated PdX6 octahedra are found in the crystal structure. Additional characterisation of the compounds was done by DTA, IR/RAMAN spectra and 207Pb MAS NMR investigations. Remarcable low field shifts were found for 207Pb.
    Notes: Entgegen Literaturangaben wurden in den Systemen PbX2 - PdX2 (X = Cl, Br) die neuen Verbindungen Pb2PdCl6(I) und Pb2PdBr6(II) aufgefunden. Sie wurden durch thermische Behandlung der binären Halogenide PbX2 und PdX2 im molaren Verhältnis 2:1 dargestellt (Einkristalle). Die Kristallstrukturen wurden mit Einkristallröntgenuntersuchungen ermittelt. I und II sind isotyp, monoklin, P21/c (Nr. 14), Z = 2, I: a = 9,037(2) Å, b = 6,224(1) Å, c = 8,162(1) Å, β = 90,31(7)º, II: a = 9,512(7) Å, b = 6,584(8) Å, c = 8,383(3) Å, β = 90,07(5)º. In Pb2PdX6 werden stark gestreckte PdX6-Oktaeder beobachtet. Die Verbindungen wurden außerdem mittels DTA, IR/RAMAN-Spektren und 207Pb-MAS-NMR-Untersuchungen charakterisiert. Für 207Pb wurde eine bemerkenswerte Tieffeldverschiebung beobachtet.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19966220721
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...