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Evidence for cardiovascular remodeling in a patient with Bartter's syndrome (1994)

Schmitz, U. ; Ko, Y. ; Becher, H. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 874-877

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ISSN: 1432-1440

Keywords: Bartter's syndrome ; Cardiovascular remodeling ; Diastolic dysfunction ; Intima/media complex

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In a 56-year-old normotensive white male subject with a 12-year history of hypokalemic alkalosis, hyperreninemia, and aldosteronism, the diagnosis of Bartter's syndrome was established on the basis of an impaired maximal renal diluting capacity and decreased distal fractional chloride absorption [CH2O/(CH2O + CCl)]. Negative urine analysis for diuretics suggested that this renal tubular defect was not secondary to diuretic (ab)use. In this normotensive patient with hyperreninemia and secondary aldosteronism, significant cardiovascular remodeling could be observed. Thus, in spite of normal arterial blood pressure and normal left ventricular systolic function (ejection fraction 〉 70%), impaired left ventricular diastolic function was observed using pulsed-wave Doppler echocardiography. Moreover, duplex analysis of the common carotid artery revealed significant intima-media hypertrophy with an average intima-media diameter of 0.9 mm (normal ≤ 0.6 mm). Also, forearm venous occlusion plethysmography revealed an abnormally high minimal forearm vascular resistance following a 10-min period of forearm ischemia handgrip exercise suggesting remodeling within the peripheral arterioles. Thus, in a patient with Bartter's syndrome and activated neurohormonal systems such as the renin-angiotensin system, cardiac and vascular remodeling can be observed in the absence of hypertension. In analogy to the results of experimental studies showing that angiotensin II and noradrenaline act as growth factors on cardiac and vascular cells, cardiovascular remodeling present in our patient with Bartter's syndrome may be explained by increased activity of angiotensin II and/or noradrenaline.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00190744

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103Rh chemical shifts and trans influence of ligands in rhodoximes and organorhodoximesInvestigations on Electronic Influence of Organyl Ligands, Part XII. For Part XI. see Ref. 2b. (1995)

Ludwig, M. ; Öhrström, L. ; Steinborn, D.

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 33 (1995), S. 984-987

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ISSN: 0749-1581

Keywords: NMR ; 103Rh ; 31P ; 13C ; rhodoximes ; organobis(dimethylglyoximato) rhodium ; complexes ; trans influence ; coupling constants ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The 103Rh NMR chemical shifts of rhodoximes [Rh(dmgH)2(PPh3)X] (1) and organorhodoximes [Rh(dmgH)2(L)R] (2, L = PPh3; 3, L = PMe3; 4, L = P(OPh)3; 5, L = SMe2; 6, L = py) were measured with a wide range of anionic ligands X, organo groups R and axial ligands L. The chemical shifts δ(103Rh) in the halide complexes 1 show the ‘normal halogen dependence’ (Cl 〉 Br 〉 I). δ(103Rh) in 2-6 depends on the axial base L in the order py 〉 SMe2 〉 PPh3 〉 P(OPh)3 ≍ PMe3 and in 2 on the organo group R in the order Et ≍ Me 〈 nPr 〈 CH2Ph ≍ CH2OMe 〈 CH2Br 〈 CH2Cl 〈 iPr 〈 Cy 〈 CH=CH2 〈 CH2SiMe3 〈 tBu 〈 cis-CH=CHPh ≍ cis-CH=CHPr 〈 Ph ≍ C≡CPh 〈 CPr=CH2. The coupling constants 1J(103Rh,31P) in 2 reflect the (NMR) trans influence of R. There is a strong correspondence between the NMR trans influence and the structural trans influence, as indicated by the bond lengths d(Rh - P).

Additional Material: 2 Ill.