ISSN:
1432-2072
Keywords:
Gepirone
;
Buspirone
;
Ipsapirone
;
Glucose utilization
;
Hippocampus
;
Lateral habenular nucleus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The azospirones gepirone (10 mg/kg), ipsapirone (10 mg/kg) and buspirone (10 mg/kg) were examined for their effect on regional cerebral glucose utilization in conscious rats using quantitative 2-deoxyglucose autoradiography. All three 5-HT1A partial agonists reduced glucose utilization in the hippocampus and dentate gyrus by 20–25% and increased glucose utilization by 38–65% in the lateral habenular nucleus; an important relay between striatal/limbic areas and the mid-brain raphe nuclei. The findings emphasize the potential importance of the hippocampus as a site of action for 5-HT1A receptor active drugs in vivo and also suggest that functional activity in the striatal/limbichabenular-raphe pathway may be influenced by gepirone, ipsapirone and buspirone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02253595
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