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  • 1995-1999  (1)
  • 1990-1994  (1)
  • Duplex sonography  (1)
  • Endoscopic release.  (1)
  • 1
    ISSN: 1432-1440
    Keywords: Cholesterol diet ; Arterial wall thickness ; Vascular reactivity ; Duplex sonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cholesterol enrichment of arteries may induce biochemical and structural abnormalities in vascular smooth muscle resulting in increased arterial contractile sensitivity. We studied the effects of a high-cholesterol diet on arterial structural properties and vascular reactivity in young rabbits. In vivo measurements of aortic intimal-plus-medial thickness using high resolution ultrasound imaging were obtained before and after 3 weeks of a high-cholesterol diet in 12 rabbits (group 2) and compared to data from 12 animals a cholesterol-free diet fed (group 1). Six rabbits (group 3) were studied before and after a 3-week, high-cholesterol diet and after a subsequent 13-week, cholesterol-free recovery diet. Blood pressure responsiveness to noradrenaline was evaluated before and at the end of each diet period. In groups 2 and 3, high dietary cholesterol caused an increase in intimal-plus-medial thickness from 0.31 mm and 0.33 mm to 0.88 mm and 0.89 mm, respectively (p〈0.001). Plasma cholesterol concentration rose from 0.9 ±0.26 mmol/l to 36.7 ± 8.56 mmol/l. There was no change in group 1. In group 3, intimal-plus-medial thickness remained increased (1.01 mm) following the cholesterol-free recovery diet despite normal plasma cholesterol. Blood pressure responsiveness to noradrenaline was markedly increased after the high-cholesterol diet (p〈0.001) in groups 2 and 3 and after the cholesterol-free recovery diet in group 3 (p〈0.001), and was directly related to intimal-plus-medial thickness (r=0.84;p〈0.001). The data indicate that short-term high dietary cholesterol in the early life of rabbits causes long-lasting biochemical and structural arterial wall abnormalities, which might not only explain the observed increase in blood pressure responsiveness to noradrenaline, but could also lead to persistent functional vascular smooth muscle alterations. The result may be a predisposition to increased vascular smooth muscle response to high dietary cholesterol in adult life and development of high blood pressure and atherosclerosis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0385
    Keywords: Key words: Carpal ligament ; Endoscopic release. ; Schlüsselwörter: Carpalband ; endoskopische Methode.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Die endoskopische Carpalbandspaltung ist eine elegante minimal-invasive Methode der Therapie des Carpaltunnelsyndroms. Vom 1. 10. 1994 bis 7. 5. 1995 wurden in einer prospektiv angelegten Studie 46 Patienten dokumentiert, die an 55 Händen endoskopisch operiert wurden. Über eine Fragebogenaktion wurden die Ergebnisse eingeholt: An 51 von 55 Händen bestanden entweder keinerlei Beschwerden mehr oder diese waren so deutlich gebessert, daß die komplette Durchtrennung des Carpalbandes angenommen werden konnte. In 4 Fällen bestanden anhaltende Beschwerden, weshalb 2 Patienten nach weiterer Kontrolle nachoperiert wurden. Als Vorteil der endoskopischen Methode erwiesen sich die kosmetisch unauffällige Narbe und die reduzierte postoperative Arbeitsunfähigkeit. Komplikationen traten nicht auf. Herausgestellt werden muß die Notwendigkeit eines sorgfältigen Trainings des operierenden Chirurgen, besonders in der Lernphase.
    Notes: Summary. The endoscopic release of the carpal ligament gives the opportunity to treat the carpal tunnel syndrome in a comfortable and minimal invasive way. Between 1 October 1994 and 7 May 1995, 46 patients who underwent endoscopic surgery on 55 hands were documented in a prospective study. The following results were taken from a questionnaire. There were not any complaints, or the complaints were so much diminished that complete division of the carpal ligament could be viewed as accomplished in 51 of 55 cases. There were continuing complaints in four cases, and after an additional check two patients were operated on again. The advantage of the endoscopic method is the inconspicuous scar and the reduced postoperative disablement. No complications have occurred.
    Type of Medium: Electronic Resource
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