Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1995-1999  (6)
  • 1990-1994  (2)
Source
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Resistance of Helicobacter pylori to antibiotics (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Resistance of Helicobacter pylori to antibiotics included in current regimens used to eradicate H. pylori is a major reason for failure. The definition of resistance is not simple, and the clinical relevance of in vitro results must be considered. The different methods of testing antibiotics cannot apply in all cases.Resistance to clarithromycin has a low prevalence rate (〈10%) and its mechanism is well defined (point mutation on the 23S rRNA genes, and decreased binding of the antibiotics to the ribosome). Its clinical relevance is not questioned and, because of a clear occurrence of a bimodal strain population, the method for detecting resistance is not crucial.Resistance to nitroimidazoles is much more common, probably in the range of 30% or more in Europe. Neither the mechanism of action of metronidazole resistance nor its mechanism of is well known. The redox potential inside the cell which is important in reducing metronidazole to its active metabolite is probably a key element, but the exact metabolites involved are not yet known. Metronidazole resistance was found to be clinically relevant when standard triple therapy was used. The relevance is questioned for triple therapies including a proton pump inhibitor, clarithromycin and metronidazole. More clinical data are needed in this field and the use of agar dilutions is recommended to assess the susceptibility of H. pylori to metronidazole.The mechanism of resistance to quinolones has been described but these compounds are not currently used for H. pylori infection. No resistance has yet been described for amoxycillin but continuous surveillance is needed in order to detect new cases, as was recently the case for tetracycline resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.11.s1.11.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Short-course therapy with amoxycillin–clarithromycin triple therapy for 10 days (ACT-10) eradicates Helicobacter pylori and heals duodenal ulcer (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Whilst the role of Helicobacter pylori eradication in managing duodenal ulcers has been established, consensus regarding the ideal regimen has not been achieved.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Patients with H. pylori-positive active duodenal ulcer were randomly assigned to receive triple therapy with amoxycillin 1000 mg b.d. + clarithromycin 500 mg b.d. + omeprazole 20 mg daily for 10 days (ACT-10) or dual therapy with clarithromycin 500 mg t.d.s. + omeprazole 40 mg daily for 14 days (Dual). No additional acid suppression was provided following eradication therapy. Endoscopy, with biopsy for culture and histology, as well as 13C-urea breath testing (13C-UBT) were performed pre-treatment to assess H. pylori infection. H. pylori eradication was established at 4–6 weeks follow-up with culture (2 antral, 1 corpus biopsies), histology (2 antral biopsies), and 13C-UBT. Ulcer healing by endoscopy and change in clinical symptoms were also assessed at 4–6 weeks.〈section xml:id="abs1-3"〉〈title type="main"〉Results:Two hundred and sixty-seven (267) patients were randomized to ACT-10 (n=137) or Dual therapy (n=130). By per-protocol and intention-to-treat analyses, H. pylori eradication at 4–6 weeks follow-up was 91% (115/127) and 88% (120/136), respectively, for ACT-10 patients and 59% (68/115) and 55% (72/130), respectively, for Dual therapy patients (P〈0.001 for both analyses). Ulcer healing was high in both treatment groups: ACT-10, 93% (118/127) and 90% (122/136), respectively; and Dual therapy, 91% (104/114) and 85% (111/130), respectively. Pre-treatment resistance to clarithromycin was low (4%, 8/214) as compared to metronidazole resistance which was over 40%. Emergence of resistance to clarithromycin was observed in 2% of patients receiving ACT-10 and in 25% of those receiving Dual therapy. ACT-10 and Dual therapy patients experienced similar rates of drug-related adverse events (33% vs. 32%, respectively) and discontinuation from therapy due to an adverse event (1.5% vs. 5%, respectively). More than 90% of patients were compliant with each prescribed medication.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:In patients with active duodenal ulcer, a 10-day course of amoxycillin–clarithromycin-based triple therapy without additional acid suppression is highly effective in eradicating H. pylori and healing duodenal ulcer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00223.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Panel discussion: breaking the link — clinical options to minimize risk (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 13 (1999), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1999.00004.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Quantitative polymerase chain reaction for the detection ofHelicobacter pylori in gastric biopsy specimens (1997)
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 143-149 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A variety of methods, including the polymerase chain reaction (PCR), are available for the detection ofHelicobacter pylori in clinical samples, but none of them can adequately quantify the organism. In the present study, the competitive PCR, a rapid and simple method for quantification ofHelicobacter pylori DNA in gastric biopsies, was used to measure the amount of DNA present inHelicobacter pylori-positive biopsies. This method is based on coamplification of an internal standard and a target DNA sequence with one set of primers. The internal standard was prepared using a nonhomologous fragment of DNA ligated to specific primers used to amplify the target DNA. This competitive DNA fragment of a desired size and containing primer templates is called a PCR MIMIC. To perform a quantitative PCR, PCR amplification reactions were spiked with known quantities of PCR MIMICs containing unknown amounts of DNA fromHelicobacter pylori-positive biopsies. The amount of target DNA was determined by visual comparison of the PCR products after establishment of the correlation between the internal control concentration and the DNA concentration in a competitive amplification reaction. The results were confirmed by a radioactive method. Quantitative PCR can be a reliable method for determining the extent ofHelicobacter pylori infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709473
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Acute otitis media in children: A study of nasopharyngeal carriage of potential pathogens and therapeutic efficacy of cefixime and amoxicillin-clavulanate (1995)
    Springer
    Infection 23 (1995), S. S79 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir führten eine große, offene, randomisierte Multizenterstudie in ganz Frankreich durch, in der die Wirksamkeit und Sicherheit der Cefixim-Suspension (8 mg/kg/Tag, zweimal täglich 10 Tage) mit derjenigen der Amoxicillin-Clavulansäure-Suspension (80 mg/kg/Tag dreimal täglich 10 Tage) bei 510 Kindern (Alter 6–36 Monate) mit akuter Otitis media verglichen wurde. Am häufigsten war der Nasopharynx zu Therapiebeginn durchStreptococcus pneumoniae (51,5%),Haemophilus influenzae (45%) undMoraxella catarrhalis (30,2%) besiedelt. 32,1% derH. influenzae und 95,3% derM. catarrhalis-Isolate waren β-Lactamasebildner. Bei 39,7% der Isolate vonS. pneumoniae fand sich einge-schränkte Penicillinempfindlichkeit. In der mit Cefixim behandelten Gruppe lag die klinische Erfolgsrate bei 87,8% (223/254), in der mit Amoxicillin-Clavulansäure behandelten Gruppe bei 87,0% (215/247). Die Verlaufskontrolle nach 5 Wochen deckte bei 15,7% (31/197) der mit Cefixim und bei 15,6% (32/205) der mit Amoxicillin-Clavulansäure behandelten Patienten Rezidive auf. Wir schließen, daß die beiden Behandlungsschemata in der Therapie der akuten Otitis media bei Kindern gleich wirksam sind.
    Notes: Summary We conducted a large, multicenter, randomized, open-label study throughout France comparing the efficacy and safety of cefixime suspension (8 mg/kg/day, b. i. d., for 10 days) versus amoxicillin-clavulanate suspension (80 mg/kg/day, t. i. d., for 10 days) in 510 children (ages 6 to 36 months) with acute otitis media. The most frequent microorganisms colonizing the nasopharynx at the start of treatment wereStreptococcus pneumoniae (51.5%),Haemophilus inflenzae (45%) andMoraxella catarrhalis (30.2%). Rates of β-lactamase positivity were 32.1% and 95.3% forH. influenzae andM. catarrhalis, respectively. Decreased susceptibility ofS. pneumoniae to penicillin was found in 39.7% of isolates. Clinical efficacy was 87.8% (223/254) for cefixime and 87.0% (215/247) for amoxicillin-clavulanate. At the 5-week follow-up visit, relapse had occurred in 15.7% (31/197) of cefixime-treated patients and in 15.6% (32/205) of those treated with amoxicillin-clavulanate. We conclude that these two regimens are equally effective in acute otitis media in children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742989
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Isolation of a urease positive thermophilic variant ofCampylobacter lari from a patient with urinary tract infection (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 895-897 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual campylobacter strain, a urease positive thermophilic variant ofCampylobacter lari, was isolated from the urine of a patient with urinary tract infection who was hospitalized because of cirrhosis and haemorrhage. The strain was isolated from urine specimens on three separate occasions. A significant serological response to the organism was also detected. This is the first documented case of extra-intestinal infection due to this group of organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967506
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    In vitro activity of rifaximin againstHelicobacter pylori (1994)
    Springer
    European journal of clinical microbiology & infectious diseases 13 (1994), S. 184-186 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01982198
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Rapid detection ofCampylobacter jejuni andCampylobacter coli isolated from clinical specimens using the polymerase chain reaction (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 355-359 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract SeventeenCampylobacter strains isolated from 16 children hospitalised with acute diarrhea were analysed by in vitro enzymatic amplification using two sets of oligonucleotide primers specific forCampylobacter jejuni andCampylobacter coli, respectively. Thirteen strains (76 %) were identified asCampylobacter jejuni and four strains (24 %) asCampylobacter coli. Subsequent bacteriological identification confirmed the identity of the same 13Campylobacter jejuni strains and the 4Campylobacter coli strains. Thus, these PCR methods enabled rapid and specific detection of all theCampylobacter jejuni andCampylobacter coli strains without any false-positive or false-negative results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02116533
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...