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  • 1995-1999  (1)
  • 1990-1994  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Reproducibility of glycaemic thresholds for activation of counterregulatory hormones and hypoglycaemic symptoms in healthy subjects (1992)
    Springer
    Diabetologia 35 (1992), S. 958-961 
    Details
    ISSN: 1432-0428
    Keywords: Autonomic symptoms ; counterregulatory hormones ; glucose thresholds ; hypoglycaemia ; neuroglycopoenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine healthy subjects were studied on two separate occasions, at least two weeks apart, using the glucose clamp technique to produce a gradual hypoglycaemia. Glucose thresholds for neuroendocrine and symptom responses varied up to 1.5 mmol/l between subjects. There was a significant correlation between individual glucose thresholds on day 1 and 2 for adrenaline (p = 0.0008), growth hormone (p = 0.007) and pancreatic polypeptide (p = 0.02), and for autonomic (p = 0.018) and neuroglycopoenic (p = 0.023) symptoms, whereas no significant correlations were found for glucagon and cortisol. The mean intra-individual differences in glucose thresholds between day 1 and 2 were 0.22 mmol/l for the hormones and 0.25 mmol/l for the symptoms. We conclude that healthy subjects differ in hypoglycaemic thresholds, and that the difference reflects individual variation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401425
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  • 2
    Electronic Resource
    Electronic Resource
    NIDDM: a rapid progressive disease Results from a long-term, randomised, comparative study of insulin or sulphonylurea treatment (1996)
    Springer
    Diabetologia 39 (1996), S. 1629-1633 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin treatment ; sulphonylurea treatment ; metabolic control.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective of the present study was to assess the relative efficacy of insulin or glibenclamide treatment for non-insulin-dependent diabetes mellitus (NIDDM) over 42 months. We performed a randomised, controlled trial allocating patients treated with diet and oral antihyperglycaemic agents to treatment with glibenclamide or insulin to achieve HbA1c levels under 7.5 %. We included 36 subjects with established NIDDM of more than 2 years' duration. Mean HbA1c levels were significantly reduced in patients allocated to insulin treatment from 9.1 ± 1.4 % before the start to 7.8 ± 1.3 % (p〈 0.05) after 1 year, and did not change significantly thereafter throughout the study period. Mean HbA1c levels increased during the study in the patients allocated to glibenclamide treatment, and 11 of 18 patients had to be switched to insulin treatment due to increasing hyperglycaemia (HbA1c 〉 10 %). Mean body weight increased in the subjects allocated to insulin by 7.2 ± 4.1 kg during the study period. In conclusion, insulin was more effective than glibenclamide treatment in obtaining control over hyperglycaemia in these patients, and once improved, glycaemic control did not deteriorate over 42 months in the insulin-treated group. Two thirds of the patients allocated to glibenclamide treatment had to be given insulin due to inadequate glycaemic control. [Diabetologia (1996) 39: 1629–1633]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050626
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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