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  • 1995-1999  (23)
  • 1985-1989  (25)
  • 1975-1979  (8)
  • 1965-1969  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Sera from 13 pregnant women carrying a fetus with a neural tube defect, and from 13 control women with normal pregnancies at the same stage of gestation were used in the culture of postimplantation rat embryos. Serum from women with normal pregnancies had no adverse effect on rat embryo growth and development. Serum from 10 of the women with affected fetuses had a deleterious effect on the rat embryos as abnormalities of neural tube closure were observed in 28% of the conceptuses compared to only 1·3% of the embryos cultured in control scrum.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 11 (1995), S. 0 
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Literature data are analysed regarding losses of body substances occurring during a period of food deprivation in rainbow trout (Oncorhynchus mykiss). Nitrogen (protein) and energy losses show a distinct dependence on fish mass (FM [g]) and water temperature (T [°C]). Several regression models for this relationship were compared with best testing estimates as follows:Nitrogen loss [mg N 2 fish−1 2 d−1] = 0.0658 e(1.037) 2 FM0.739(n= 49, 9–20°C, 5–400g fish mass, P 〈 0.001, B = 0.826)Nitrogen-corrected energy loss [J 2 fish−1 2 d−1] = 22.09 e(1.034) 2 FM0.833(n= 63, 9–25°C, 8–400 g fish mass, P 〈 0.001, B = 0.887).For nitrogen loss as well as for nitrogen-corrected energy loss, the metabolic rate shows a progressive increase with rising water temperature. The temperature coefficient increases in magnitude as temperature increases. The introduction of a general common exponent (0.8 instead of 0.739 for nitrogen loss and 0.833 for energy loss) for fish mass decreases the precision of the estimate. The equations could serve as a base for estimating net protein and net energy maintenance requirements of rainbow trout. Possible limitations, caused by uncertainities in estimating the elevated metabolic rate by food intake and ingestion, are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 21 (1998), S. 0 
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: We propose a simple oscillatory model of crassulacean acid metabolism (CAM) describing the CO2 uptake and nocturnal acidification of CAM plants by a system of coupled non-linear differential equations. Large differences in the content of metabolite pools are treated using a pseudo-steady-state approach. For the first time, simulations of the CAM cycle investigate its dependence on all three major control parameters simultaneously: temperature, photon flux density and external CO2 concentration. Under stationary conditions in time the model shows either endogenous rhythmicity or two distinct steady states. Stability boundaries are calculated in parameter space.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of prosthodontics 8 (1999), S. 0 
    ISSN: 1532-849X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to assess distortion inherent in casting, soldering, and simulated porcelain firings of screw-retained, implant-supported three-unit fixed partial dentures (FPDs).〈section xml:id="abs1-2"〉〈title type="main"〉Materials and MethodsTen wax patterns were fabricated on a die-stone cast containing two implants, 20 mm apart from center to center. Five specimens were cast in a high-palladium alloy, exposed to simulated porcelain firings, sectioned, and then soldered with low-fusing solder. Five specimens were cast, sectioned, soldered with high-fusing solder, and then exposed to simulated porcelain firings. For each specimen, two horizontal and six vertical distances between appropriately scribed reference points were measured with a traveling microscope. Comparisons were made among the various measurements taken after wax-pattern fabrication, casting, high- and low-fusing soldering, and each porcelain firing. Data were analyzed using a repeated-measures factorial ANOVA (α= 0.05).〈section xml:id="abs1-3"〉〈title type="main"〉ResultsSignificant difference was detected in the amount of horizontal distortion during casting (53 ± 24 μm) and high-fusing soldering (−49 ± 50 μm), as well as in the amount of horizontal distortion during high-fusing soldering (−49 ± 50 μm) and low-fusing soldering (17 ± 26 μm). However, no clinically significant difference was found in the amount of horizontal distortion during casting, low-fusing, and high-fusing soldering. The greatest amount of distortion during the simulated porcelain firings took place during the oxidizing cycle.〈section xml:id="abs1-4"〉〈title type="main"〉ConclusionsSoldering did not improve the casting misfit of a three-unit implant-retained FPD model. Metal-ceramic implant frameworks should be oxidized before intraoral fit evaluation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 22 (1995), S. 0 
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Treatment of molar teeth with severe furcation involvement allows for differing therapies of which the tunneling procedure has been least studied. While subsequent root caries in furcal exposed teeth was believed a major shortcoming, successful periodontal therapy is primarily dependent upon the stability of the attachment and intrafurcal and interproximal bone. We evaluated in each of 18 subjects (10 female, 8 male) a molar tooth with deep grade II/III furcation involvement at time of presentation (T-0), to 1st post-surgical recall following a tunneling procedure (T-1), to most immediate last recall (T-2; mean time T-0 to T-2, 5.80±0.83 years). Assessments included O'Leary's plaque index (P1-I), attachment levels (AL), root caries and radiographic bone loss. The mean P1-I from T-0 to T-2 decreased 56.8% with some plaque at T-2 detected in furcations of 7/18 teeth. AL across all time periods were not significantly difference except for palatal/lingual AL which from T-0 to T-2 were significantly different. Root caries was found in only 3 teeth at T-2. Adequate radiographs were available for 8 surgically tunneled mandibular molars for analysis of 5 measurements of osseous levels i.e. the mesial and distal levels of the intrafurcal and the interproximal osseous crests, and the distal interproximal osseous crest of a mesial adjacent single-rooted reference tooth which received osseous surgery at the same time. Mean time change values (T-1 to last radiograph taken. T-2a; mean time 3.0±0.7 years) showed no significant difference among the 5 points measured. These results indicate no difference in AL nor loss of furcal or proximal crestal bone in surgically tunneled mandibular molars when compared with an adjacent tooth receiving osseous surgery.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to determine whether the mucosal alterations of the dorsal rat tongue produced by Candida albicans infection were reversible upon treatment with the antifungal drug ketoconazole. Following experimentally-produced infection, 17 rats showed clinical evidence of persistent lesions over a period of 20 weeks. Eight of these animals were then treated with ketoconazole daily for 2 weeks (20 mg/kg/day). Appropriate non-infected controls and ketoconazole-only controls were also maintained. Five weeks after the ketoconazole treatment, all animals were killed and the dorsal tongues evaluated clinically and histologically. Control groups showed no abnormalities. Of the 8 animals in the treated-lesion group, all showed lesional resolution, while only 2 of the 9 animals in the untreated-lesion group showed resolution of their lesions (p=0.002). These findings indicate that the epithelial changes produced by this candidal isolate for this period of time are reversible.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 16 (1987), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to examine the behavior of Candida albicans in an oral mucosal model, 16 isolates of the organism were collected from a variety of clinical settings and were inoculated weekly, in equal numbers and concentrations, into the mouths of separate groups of 20 female Sprague-Dawley rats. Oral swabs were taken bi-weekly in order to monitor the presence of the yeast. After 16 weeks, the animals were killed and the tongues were examined grossly and histologically. Six isolates demonstrated the ability to produce characteristic dorsal tongue lesions to varying degrees (1/20; 1/20; 1/20; 2/20; 3/20; and 12/20). Of the remaining 10 isolates, 5 showed hyphal penetration of the keratin layer of the dorsal tongue epithelium, yet no mucosal reaction was elicited and no lesion was produced (1/19; 2/19; 4/20; 5/20 and 5/20). These findings support the concept that C. albicans exhibits a spectrum of mucosal pathogenicity for dorsal rat tongue.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1424
    Keywords: Key words: Crassulacean acid metabolism — Endogenous rhythm — Lipid membrane structure — Phase transition — Osmotic cell pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. The observed endogenous circadian rhythm in plants performing Crassulacean acid metabolism is effected by malate transport at the tonoplast membrane. Experimental and theoretical work asks for a hysteresis switch, regulating this transport via the ordering state of the membrane. We apply a schematic molecular model to calculate the thermally averaged order parameter of the membrane lipid structure in its dependence on external parameters temperature and area per molecule. The model shows a first order structural phase transition in a biologically relevant temperature range. Osmotic consequences of malate accumulation can trigger a transition between the two phases by changing the surface area of the cell vacuole. Estimation of the energy needed to expand the vacuole under turgor pressure because of osmotic changes while acidifying shows that energy needed as latent heat for the calculated change between phases can easily be afforded by the cell. Thus, malate content and the coexisting two phases of lipid order, showing hysteretic behavior, can serve as a feedback system in an oscillatory model of Crassulacean acid metabolism, establishing the circadian clock needed for endogenous rhythmicity.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2013
    Keywords: Electron microprobe analysis ; Volume expansion ; Intracellular electrolytes ; Renal tubular cells ; Natriuretic mechanisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has previously been shown that during mannitol-saline volume expansion (VE) Na transport was inhibited 50% by harvested proximal tubular fluid without a change in paracellular shunt pathway permeability to Na. To determine whether this inhibition was due to changes in cellular entry step or an effect on the pump itself, intracellular element concentrations were measured by electron microprobe X-ray ranalysis in proximal tubular cells of control (non-expanded, NE) and VE rats. Na i , Cl i and phosphorus i were increased (mean±S.E.) from 19.3±0.8 to 23.4±0.6, 15.8±0.4 to 21.3±0.4 and 124.3±2.6 to 138.0±1.8 mmol · kg−1 wet weight (P〈0.001) respectively while K i remained unchanged: 122.9±2.2 and 124.2±1.3 mmol · kg−1 wet weight. The increases in Na i and Cl i were in excess of cell shrinkage produced by the hyperosmolal peritubular environment while the unchanged K i in the face of cell shrinkage indicates and actual loss. It is concluded that mannitol-saline VE inhibits the Na pump producing a rise in Na i and a fall in K i .
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2013
    Keywords: Acute metabolic acidosis ; Renal distal electrolyte transport ; Renal cell electrolyte concentrations ; Individual distal tubule cells ; Transmembrane electrolyte concentration gradients ; Electron microprobe analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the effect of acute metabolic acidosis on potassium, sodium and chloride gradients across the apical membrane of proximal and distal tubule cells by determining electrolyte concentrations in individual cells and in tubule fluid employing electron microprobe analysis. Cellular measurements were performed on freeze-dried cryosections of the renal cortex, analysis of tubule fluid electrolyte concentrations on freeze-dried microdroplets of micropuncture samples obtained from proximal and from early and late distal collection sites. Acidosis (NH4Cl i.v. and i.g.) induced a substantial rise in plasma potassium concentration without significant effects on cell potassium concentrations. Potassium concentrations along the surface distal tubule were also unaltered; thus the chemical driving force for potassium exit from cell to lumen was not affected by acidosis. In all but intercalated cells acidosis markedly increased cell phosphorus concentration and cell dry weight indicating cell shrinkage and thus diminution of cell potassium content. Because the increase in intracellular chloride concentration exceeded the increase in plasma chloride concentration, the chemical chloride gradient across the contraluminal membrane was markedly depressed by acidosis.
    Type of Medium: Electronic Resource
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