Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1995-1999  (3)
  • 1985-1989  (1)
  • Industrial Chemistry and Chemical Engineering  (2)
  • 6-mercaptopurine  (1)
  • 68M20  (1)
Material
Years
  • 1995-1999  (3)
  • 1985-1989  (1)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Computing 57 (1996), S. 255-271 
    ISSN: 1436-5057
    Keywords: 90B35 ; 68M20 ; k-partitioning containing kernels ; NP-complete ; worst case analysis ; LPT-algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Seik≥2 eine natürliche Zahl undG= $$\{ g_1 ,g_2 , \cdots ,g_m \} \cup \{ t_1 ,t_2 , \cdots ,t_n \} $$ eine Menge von höchstenskm nichtnegativen ganzen Zahlen. Gesucht ist eine Partition vonG= $$\{ g_1 ,g_2 , \cdots ,g_m \} \cup \{ t_1 ,t_2 , \cdots ,t_n \} $$ inm Teilmengen, die jeweils nicht mehr alsk Elemente enthalten, sodaß alleg i (Kerne genannt) unterschiedlichen Teilmengen zugeordnet werden und die maximale Summe von Zahlen in einer dieser Teilmengen möglichst klein wird. Wir zeigen zunächst, daß für jedesk≥3 dieses Problem NP-vollständig im starken Sinne ist. Als Heuristik für dieses Problem benutzen wir eine revidierte Version des bekannten LPT-Algorithmus für das Multiprozessorscheduling-Problem. Fürk=3 zeigen wir eine Worst-Case Schranke von 3/2–1/2m.
    Notes: Abstract LetG= $$\{ g_1 ,g_2 , \cdots ,g_m \} \cup \{ t_1 ,t_2 , \cdots ,t_n \} $$ be a list of items with nonnegative weights assigned andk≥2 be an integer. The objective is to find an assignment of the items to the bins such that allg i (called kernels) are assigned to different bins, such that no bin contains more thank items, and such that the maximum weight assigned to any bin becomes minimum. In this paper, we first prove that the problem is NP-complete in the strong sense for anyk≥3. As heuristic for this problem, we use a modified version of the famous LPT-algorithm for multiprocessor scheduling, and we show a worst case bound of 3/2–1/2m fork=3.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1041
    Keywords: azathioprine ; 6-thiouric acid ; 6-mercaptopurine ; renal transplantation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (6-TU) and 6-mercaptopurine (6-MP), metabolites of AZA, may provide more readily measurable indices of the pharmacologic activity of AZA. In order to evaluate the utility of 6-TU and 6-MP plasma concentrations in monitoring AZA therapy, we studied their pharmacokinetics in 6 renal transplant patients, and their in vitro immunosuppressive potency in a mixed lymphocyte proliferation assay. A peak plasma 6-TU concentration of 710.7 ng/ml was observed at 3.8 h after oral dosing. Good correlation was observed between the elimination t1/2 of 6-TU and serum creatinine, and between AUC over 24 h and serum creatinine. However, we did not observe a second peak in plasma 6-TU concentration that could be attributed to the degradation of active AZA metabolites. 6-MP plasma concentrations in the patients were low (mean peak concentration 36.0 ng/ml) and rapidly disappeared within 8 h. In vitro immunosuppressive activity could not be demonstrated for 6-TU over a concentration range of 1.25 ng/ml to 0.25 mg/ml. We conclude that 6-TU is pharmacologically inert and is primarily eliminated by the kidneys. Our findings currently do not support the use of plasma concentrations of 6-TU or 6-MP to monitor AZA therapy. In order to optimize AZA therapy, analytical techniques that are technically feasible and that can directly quantify the active intracellular thiopurines are being explored.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0268-2605
    Keywords: radiolabeling ; trimethylamine-carboxyborane ; trimethylamine-carboxymethoxyborane ; leukemic cell uptake ; binding to nucleic acids and protein ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The anti-neoplastic agents trimethylamine-carboxyborane and its corresponding methyl ester have successfully been radiolabeled with carbon-14 in the carboxyl group. Using the radiolabeled agents we have shown that their L1210 leukemia cell uptake appeared to be by a passive process and binding of the agents to DNA, RNA and protein over 24 h was minimal.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 10 (1996), S. 485-493 
    ISSN: 0268-2605
    Keywords: thiosemicarbazones ; metal complexes ; anti-inflammatory ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The thiosemicarbazones and their related metal complexes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg-1. They were effective in blocking induced edema and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti-inflammatory agents is multifold. First, Tumor Necrosis Factor-alpha (TNFα) and Interleukin-1 (IL-1) release was markedly reduced by the agents. Second, high-affinity receptor binding on fibroblasts of TNFα and IL-1 was significantly inhibited. Third, cellular events, e.g. lysosomal enzymes of specific cells, such as macrophages, were inhibited and prostaglandin cyclo-oxygenase and leukotriene 5′-lipoxygenase enzymic synthetic rates were significantly reduced, which should cause an overall reduction of the inflammatory process.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...