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  • 1995-1999  (2)
  • 1985-1989  (2)
  • Autoreceptors  (2)
  • Neurotransmitter
  • Polymer and Materials Science
  • 1
    Electronic Resource
    Electronic Resource
    Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 597-606 
    Details
    ISSN: 1432-1912
    Keywords: Key words Microdialysis ; 5-HT release ; Chronic antidepressant ; Citalopram ; 5-HT reuptake inhibitor ; Tolerance ; Autoreceptors ; Frontal cortex ; Dorsal hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rats were administered the selective serotonin (5-HT) uptake blocker citalopram or saline for 14 days to determine if prolonged treatment would lead to changes in extracellular 5-HT or autoreceptor sensitivity. One day after drug withdrawal, dialysis probes were implanted in the frontal cortex and dorsal hippocampus. Dialysis experiments were carried out using chloral hydrate anesthetized rats. The experimental protocol comprised the administration of three consecutive drug challenges: (1) After stable baseline levels were obtained, citalopram was infused through the dialysis probes to locally block uptake in the forebrain. (2) Subsequently, a 5-HT1B receptor agonist (RU24969 or CP93,129) was infused through the probe to test for changes in terminal autoreceptor sensitivity. (3) Last, citalopram was administered systemically to test the effect of indirect activation of somatodendritic autoreceptors. Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. The results indicate that during local infusion of citalopram extracellular 5-HT was significantly higher in the dorsal hippocampus of the chronic citalopram as compared to saline treatment group. This difference persisted throughout the full time course of the experiment. However, the decreases in 5-HT levels produced by local infusion of a 5-HT1B receptor agonist or after systemic citalopram administration were not significantly different between the chronic citalopram and saline treated groups. There were no significant differences between chronic citalopram and saline treated animals in frontal cortex. These results suggest that prolonged inhibition of 5-HT uptake may produce a selective change in the regulation of release from median raphe 5-HT neurons, but this change could not be clearly linked to a change in nerve terminal or somatodendritic autoreceptor sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171317
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 597-606 
    Details
    ISSN: 1432-1912
    Keywords: Microdialysis ; 5-HT release ; Chronic antidepressant ; Citalopram ; 5-HT reuptake inhibitor ; Tolerance ; Autoreceptors ; Frontal cortex Dorsal hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were administered the selective serotonin (5-HT) uptake blocker citalopram or saline for 14 days to determine if prolonged treatment would lead to changes in extracellular 5-HT or autoreceptor sensitivity. One day after drug withdrawal, dialysis probes were implanted in the frontal cortex and dorsal hippocampus. Dialysis experiments were carried out using chloral hydrate anesthetized rats. The experimental protocol comprised the administration of three consecutive drug challenges: (1) After stable baseline levels were obtained, citalopram was infused through the dialysis probes to locally block uptake in the forebrain. (2) Subsequently, a 5-HT1B receptor agonist (RU24969 or CP93,129) was infused through the probe to test for changes in terminal autoreceptor sensitivity. (3) Last, citalopram was administered systemically to test the effect of indirect activation of somatodendritic autoreceptors. Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. The results indicate that during local infusion of citalopram extracellular 5-HT was significantly higher in the dorsal hippocampus of the chronic citalopram as compared to saline treatment group. This difference persisted throughout the full time course of the experiment. However, the decreases in 5-HT levels produced by local infusion of a 5-HT1B receptor agonist or after systemic citalopram administration were not significantly different between the chronic citalopram and saline treated groups. There were no significant differences between chronic citalopram and saline treated animals in frontal cortex. These results suggest that prolonged inhibition of 5-HT uptake may produce a selective change in the regulation of release from median raphe 5-HT neurons, but this change could not be clearly linked to a change in nerve terminal or somatodendritic autoreceptor sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171317
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Evidence for acetylcholine as a neurotransmitter in the statocyst of Octopus vulgaris (1986)
    Springer
    Cell & tissue research 243 (1986), S. 429-436 
    Details
    ISSN: 1432-0878
    Keywords: Statocyst receptor systems ; Acetylcholine ; Neurotransmitter ; Efferent fibre system ; Octopus vulgaris (Cephalopoda)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Evidence is presented for acetylcholine as neurotransmitter in the sensory epithelia (macula and crista) of the statocyst of Octopus vulgaris, based on the following techniques: (i) histochemical assay of acetylcholinesterase at light- and electron-microscopical levels, in combination with the detailed knowledge of the ultrastructural and neuronal organization of the receptor epithelia; (ii) lesion/degeneration experiments of the efferent fibre system; (iii) radiochemical assay of acetylcholine; and (iv) bioassay of acetylcholine. All data support the hypothesis that in the statocyst of O. vulgaris acetylcholine acts as a neurotransmitter in the efferent fibre system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251060
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Kinetics for the tensile strength degradation of nylon and kevlar yarnsPresented as Paper 86-2478 at the AIAA 9th Aerodynamic Deceleration and Balloon Technology Conference, Albuquerque, NM, October 7-9, 1986. (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 37 (1989), S. 2213-2227 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The tensile strength degradation of nylon 66 and Kevlar 29 yarns was studied at elevated temperatures and over a broad range of relative humidities. The degradation rates for nylon are initially slow but increase rapidly, suggesting the depletion of an inhibitor. Kevlar showed no evidence for similar inhibitor action. The effect of relative humidity on degradation can be very large, especially at values in the 90-100% range and at elevated temperatures. Degradation is governed by thermal-oxidative and moisture-induced mechanisms. At the very high humidities and elevated temperatures, the moisture-induced degradation predominates. Rate relationships were developed in which contributions from each mechanism were considered. Calculated degradation from these relationships agrees well with observed degradation over a broad range of temperatures and humidities.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1989.070370813
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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