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  • 1
    ISSN: 1432-1750
    Keywords: Sarcoidosis ; Tuberculosis ; TSA ; FPEC ; GLC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To explore further the possible etiologic role of mycobacteria in the development of sarcoidosis, we measured free, nonbound tuberculostearic acid (TSA, 10-methyloctadecanoic), a component of mycobacteria, in the sera of subjects with sarcoidosis or active untreated pulmonary tuberculosis and in healthy controls by use of frequency-pulsed electron capture gas-liquid chromatography (FPEC-GLC). The selective analytic system is capable of measuring as little as 15-fmol quantities of free, nonbound TSA in serum and cerebral spinal fluid. We found that TSA was present in the sera of all subjects with Mycobacterium tuberculosis (n = 10) but was undetectable in subjects with sarcoidosis (n = 15) and in healthy controls (n = 15), thereby suggesting that if sarcoidosis is caused by a mycobacterial organism, TSA is not produced or does not gain access to the systemic circulation in quantities sufficient for measurement. However, in the course of the studies we found that a peak, designated p11, was elevated in the sera of all subjects with acute sarcoidosis (n = 4). Also, a peak designated p3 was reduced significantly in all subjects with acute and chronic sarcoidosis and absent in subjects with M. tuberculosis compared with healthy controls. Both peaks were later shown by chemical analysis and mass spectral studies to be carboxylic acids not previously associated with specific disease entities. Follow-up detailed studies will be needed to determine if quantitation of these unique carboxylic acids will be useful in differentiating sarcoidosis from other disorders.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 28 (1989), S. 127-144 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The successive quadratic programming (SQP) method is used with the finite element method (FEM) to solve frictionless geometrically non-linear contact problems involving large deformations of the elastica in the presence of flat rigid walls. To formulate the SQP problems, the potential energy (PE) is expanded in a Taylor series of second order in displacement increments about a configuration near a contact solution. The SQP problems consist of minimizing the Taylor expansion of the PE subject to the inequality constraints which represent contact. The quadratic programming (QP) method is made part of a Newton-Raphson (NR) search in which the QP corrections are made when a NR step does not satisfy the constraints. A revised simplex method developed by Rusin is used to solve the QP problems. The elastica is modelled with a total Lagrangian FEM developed by Fried. Solutions are obtained for the end loaded buckled elastica in point contact with a rigid wall and for a uniformly loaded elastica in regional contact with a rigid wall. The problems are also solved using a penalty method. The results obtained for the point contact problem are compared to an analytical solution. Calculations were made to obtain numerical information on maximum load step size and the number of inverse operations required for each load step. Cases in which the elastica stiffened substantially as a result of the initiation of contact are also discussed.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 9 (1989), S. 151-165 
    ISSN: 0271-2091
    Keywords: Numerical analysis ; Fluid flow ; Rotating circular duct ; Finite cell method ; Finite element method ; Swirl ; Inlet boundary conditions ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical analysis of the flow pattern in the inlet region of a circular pipe rotating steadily about an axis parallel to its own is presented. Both finite cell and finite element methods are used to analyse the problem and they give qualitatively similar results which show that a swirling fluid motion is induced in the pipe inlet region. The analyses show that the direction of swirl is opposite to that of the pipe rotation when viewed along the flow axis and that its magnitude depends on the speed of pipe rotation and throughflow Reynolds number. Neither numerical analysis predicts the marked upturn in friction factor (or pressure drop) which has been observed experimentally. However, a dependence on the pipe inlet boundary conditions is demonstrated.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 23 (1996), S. 1241-1262 
    ISSN: 0271-2091
    Keywords: axisymmetric flow ; vortex method ; laminar flow ; entrance length ; steady and oscillating flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Steady and oscillating axisymmetric tube flows are modelled using a vorticity transport algorithm. The axisymmetric convective -diffusive Navier-Stokes equations are solved using a splitting technique. Axisymmetric ring vortex filaments are introduced on the walls and subsequently convected and diffused throughout the flow field. An axisymmetric equation similar to the Oseen diffusion equation is used to diffuse the ring vortex filaments. Vorticity is reflected from the tube walls using two techniques. Results are presented for the developing Poiseuille flow and for the developed flow in the form of the entrance length and the axial velocity and vorticity profiles. Good agreement is achieved with a finite difference method in the developing region of Poiseuille flow. The developed flow results are compared with the analytical solutions. The developed profiles of velocity and vorticity have errors of less than 0ċ3 per cent for both methods of dealing with reflection of diffusion at the bounding surfaces and similar accuracy is obtained for the velocity profiles in oscillating flow except at the wall. Oscillating flow is produced with a discretized sinusoidal piston motion. Velocity profiles, boundary layer thickness and entrance length are presented for oscillating flow. Good agreement is achieved for low-Womersley-number non-dimensional frequency. At higher values of this parameter, flows are inaccurately simulated, because the number of piston positions used to discretize the piston motion is inversely proportional to the non-dimensional frequency.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
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