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  • 11
    Electronic Resource
    Electronic Resource
    Lengthening osteotomy of the fibula for post-traumatic malunion (1998)
    Springer
    International orthopaedics 22 (1998), S. 149-152 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resumé. Nous avons analysé six cas de raccourcissement posttraumatique du péroné. Differents types de fracture et de traitement ont menés à cette situation, qui, cliniquement se caracterise par des douleurs au niveau de la cheville et une déviation en valgus et rotation externe du pied. Tous les péronés ont été corrigés par des osteotomies d’allongement (ORP), soit horizontalement ou en forme de ”z”. Nos résultats montrent que la réconstruction opératoire d’une mortaise élargie constitute une intervention relativement simple qui donne de bon résultats et qui peu ralentir ou même arrêter la progression d’une arthrose posttraumatique. En conséquence l’ORP devrait constituer le traitement de choix dans les cas de raccourcissement posttraumatique même si des signes de dégénerescence arthrosique sont présents.
    Notes: Summary. Relative shortening of the fibula may occur after any type of ankle fracture when the lateral malleolus is involved. Patients complain of pain and restriction of their daily and sporting activities. Clinically, there is valgus of the hind foot due to abduction and lateral rotation of the talus. The goal of treatment is to restore the initial length of the fibula by a horizontal or Z-osteotomy, which will also correct the malposition of the talus. This study shows that the operative reconstruction of a widened mortise is a relatively safe procedure, independent of the type of osteotomy used. Lengthening of the fibula is an important step in the treatment of the painful ankle when the fibula is short after trauma, even when degenerative changes of the joint are already present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050229
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  • 12
    Electronic Resource
    Electronic Resource
    Possible control mechanism of cell motility in the gorgonian Eunicella cavolinii (1985)
    Springer
    Marine biology 84 (1985), S. 225-231 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In a previous study it was demonstrated that a lectin controls cell-cell interaction in the gorgonian Eunicella cavolinii (Koch) as a negative modulator. Now we describe the procedure to purify this lectin to homogeneity; its molecular weight is 23 400. The homologous proteoglycans were identified as positive modulators of cell-cell (and/or cell substrate) interaction. The purified single proteoglycan aggregates were 1200±700 nm long and the distance between the attachment points of the proteoglycan subunits was about 45 nm. The glycosaminoglycan residues of the gorgonian proteoglycans were identified as hyaluronic acid (35.5%), heparan sulfate (47.9%) and dermatan sulfate (14.1%). Binding studies with immobilized homologous proteoglycan preparations revealed that gorgonian cells attach to this substratum presumably via its glycosaminoglycans. Quantitative determinations of these two modulators of cell-cell recognition in the three regions of individual colonies revealed concentration gradients these concentration differences reflect a lower cell motility in the polyp-bearing branches and a higher motility of the cells in the polyp-free stem and in the basis, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00392491
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  • 13
    Electronic Resource
    Electronic Resource
    Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice (1988)
    Springer
    Psychopharmacology 94 (1988), S. 74-78 
    Details
    ISSN: 1432-2072
    Keywords: Piracetam ; Choline ; m-Cholinoceptor density ; Frontal cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevatedm-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30–40%, but had no effect onm-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam onm-cholinoceptor density as determined by the specific binding of tritiated QNB was not affected by concomitant daily treatment with either choline (200 mg/kg) or scopolamine (4 mg/kg). It is concluded that the effect of piracetam onm-cholinoceptor density could explain the positive effects which have been reported for combinations of cholinergic precursor treatment with piracetam on memory and other cognitive functions in aged experimental animals and patients and could also represent part of the possible mechanism of action of piracetam alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735884
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  • 14
    Electronic Resource
    Electronic Resource
    Change in frequency of radiation induced micronuclei during interphase of four-cell mouse embryos in vitro (1986)
    Springer
    Radiation and environmental biophysics 25 (1986), S. 195-199 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Two-cell mouse embryos were X-irradiated (2 Gy) in vitro. Comparison of the frequency of micronuclei in the early interphase of the four-cell stage with that in the late interphase revealed a small, but significant loss of micronuclei during interphase: 27.9 versus 23.4 micronuclei per 100 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221226
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  • 15
    Electronic Resource
    Electronic Resource
    Enhancement of radiation effects by mercury in early postimplantation mouse embryos in vitro (1986)
    Springer
    Radiation and environmental biophysics 25 (1986), S. 213-217 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Two-cell mouse embryos were X-irradiated (1 Gy) and immediately thereafter exposed to mercuric chloride (3 µM) up to the blastocyst stage. When combined treatment started shortly (about 1 to 2 h) before mitosis to the four-cell stage, blastocyst formation, hatching of blastocysts, trophoblast outgrowth and ICM formation were impaired stronger than expected from the addition of the single effects. The enhancement of risk was maximal for hatching of blastocysts and no further increase was observed for trophoblast outgrowth and ICM formation. When exposure of embryos to X-rays and mercury began about 5 to 6 h before mitosis to the four-cell stage, only additive effects were obtained for the endpoints mentioned above.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221228
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  • 16
    Electronic Resource
    Electronic Resource
    Time factors in combined exposures of mouse embryos to radiation and mercury (1988)
    Springer
    Radiation and environmental biophysics 27 (1988), S. 115-121 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary There are situations in which the exposure to more than one agent results in an enhanced risk for the exposed organism, that is in which the observed effect exceeds the effect expected from the addition of the individual effects. Our knowledge of such hazards is rather limited, in particular for those agents that occur in the environment of man. When early mouse embryos in vitro were exposed to ionizing radiation and mercuric chloride, the observed risk was higher than expected from the individual effects. This increase in risk was due to an interaction between mechanisms induced by ionizing radiation and mercury. To gain some more insight into the mode of interaction, the time requirements of mercury exposure were studied. The amount of interaction did not depend on mercury exposure before or during irradiation. However, to achieve an enhanced risk, exposure had to start as soon as possible after irradiation and had to last as long as possible. This time dependence suggests that if inhibition of DNA-repair is involved in the mechanism of interaction at all, then there must be an additional late process that is also impaired by mercury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01214601
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  • 17
    Electronic Resource
    Electronic Resource
    No indications of an enhanced UV-light-induced unscheduled DNA synthesis in splenocytes of mice following a low-dose irradiation in vivo or in vitro (1995)
    Springer
    Radiation and environmental biophysics 34 (1995), S. 121-125 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract One of the open questions regarding the adaptive response to ionizing radiation is whether it can be induced in G0 lymphocytes. In the majority of experiments in which an adaptive response in G0 lymphocytes was observed, the adapting dose was applied in vivo. In order to investigate whether there is some in vivo component of adaptive response, mouse splenocytes of the C57BL/6 strain were irradiated with 0.1 Gy x-rays either in vivo or in vitro, and their UV-light-induced unscheduled DNA synthesis (UDS) levels were determined autoradiographically. An augmented UV-light-induced UDS following an adapting dose applied in vivo has previously been described by several authors in splenocytes of C57BL/6 mice, indicating that the adapting dose enhanced the DNA repair capacity of lymphocytes. In the present investigation, however, no evidence of an adaptive response could be seen regardless of whether the adapting dose was given in vivo or in vitro. Those results present a further indication for the fact that the adaptive response to ionizing radiation is not always inducible, even in lymphocytes of an inbred mouse strain in which its existence has been reported before.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275217
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  • 18
    Electronic Resource
    Electronic Resource
    Book reviews (1996)
    Springer
    Radiation and environmental biophysics 35 (1996), S. 60-60 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211245
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  • 19
    Electronic Resource
    Electronic Resource
    Activation of endogenous C-type retroviral genomes by internal alpha-irradiation of mice with224Radium (1985)
    Springer
    Radiation and environmental biophysics 24 (1985), S. 17-25 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Sensitive cocultivation techniques were applied to study the radiation-induced activation of endogenous retroviral genomes in different mouse strains by the alpha-emitting radionuclide224Radium. Activated infectious C-type retroviruses were detected in spleen, bone marrow and bone tissues of C57BL/6-, BALB/c- and NMRI mice. The titres of high-dose-irradiated animals were higher than those found in low-dose-irradiated animals. Infectious retrovirus could be detected with a dose of 13.2 rad (maximum dose rate 0.9 rad/day) in the skeleton, and a dose of 4.2 rad (maximum dose rate 0.3 rad/day) in the spleen. The virus activation pattern was different in the three mouse strains. These data indicate that activation of endogenous retroviral genomes by alpha-irradiation shows a dose-effect relationship and a dependence on the genetic background of the mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212650
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  • 20
    Electronic Resource
    Electronic Resource
    Effects of cell cycle specific exposure to 3H-thymidine or 3H-arginine on development and cell proliferation of mouse embryos (1996)
    Springer
    Radiation and environmental biophysics 35 (1996), S. 267-271 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract One-cell mouse embryos were exposed to either 3H-thymidine (100 or 200 kBq/ml) or 3H-arginine (2.5 to 50 kBq/ml) for 2 h either in G1, S or G2 phase. 3H-Arginine affected embryonic development and cell proliferation in an activity-dependent way irrespective of the cell cycle stage exposed, whereas 3H-thymidine was effective only at higher activities and only after exposure during S phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004110050039
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