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  • 1
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Fibromyalgie ; generalisierter Schmerz ; Hörschwellen ; Wahrnehmungsstörung ; Key words Fibromyalgia ; widespread pain ; hearing threshold ; perceptual dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde geprüft, inwiefern sich Fibromyalgiepatienten nicht nur in der somatosensorischen, sondern auch in der Wahrnehmung und Verarbeitung externer Reize von Kontrollprobanden ohne generalisierte Schmerzen unterscheiden. Dazu wurden 30 Fibromyalgiepatienten mit 36 überwiegend schmerzfreien Kontrollprobanden hinsichtlich auditiver Wahrnehmungsleistungen verglichen. Die Gruppen waren nach Alter und dem Ausmaß hörorganisch nachweisbarer Schädigungen parallelisiert. Audiometrisch wurden Aversions- und Hörschwellen bestimmt. Zusätzlich machten die Teilnehmer Angaben zur Lärmerfahrung im Alltag, zur Vulnerabilität für Lärmstreß und zu fibromyalgieassoziierten Beschwerden. Die Ergebnisse zeigen bei Fibromyalgiepatienten die erwartete frequenzunabhängig reduzierte auditive Aversionsschwelle sowie im oberen Frequenzbereich einen asymptomatischen Hörverlust. Als gruppenübergreifend signifikantes Korrelat der Hörschwellenerhöhung erwies sich die selbstberichtete Lärmerfahrung am Arbeitsplatz, die bei Fibromyalgiepatienten erhöht war. Die Bewertung von Alltagslärm kovariierte ebenso wie die bewertungsabhängige auditive Aversionsschwelle mit der klinischen Schmerzausdehnung. Aversions- und Hörschwellendifferenzen werden als zwei Formen vorbewußter oder bewußter Methoden der Reizabschirmung bei Fibromyalgiepatienten interpretiert. Die Ergebnisse sprechen für eine nicht nur schmerzspezifische Störung der Reizverarbeitung. Erhöhte multilokuläre Druckschmerzhaftigkeit bei Fibromyalgie kann als eine von mehreren Manifestationen einer durch allgemeine Schwellenveränderungen und reduzierte Differenzierungsfähigkeit gekennzeichneten Reaktion auf externe Stimulation verstanden werden.
    Notes: Summary We examined to what extent patients with fibromyalgia differ from painfree control subjects in the perception and processing not only of somatosensory but also of external stimuli. For this purpose the acoustic perception of 30 patients with fibromyalgia was compared with that of 36 generally pain-free age and gender matched subjects. The groups were also controlled for organic disease of pathological dysfunction of the ear and auditory nerves. Thresholds of unpleasantness and hearing thresholds were determined autiometrically for various frequencies. In addition the participants rated their experience of daily noise, vulnerability to acoustic stress, and functional and affective complaints associated with fibromyalgia. As expected the results show reduced unpleasantness thresholds for all frequencies and a nonsymptomatic hearing loss for higher frequencies. The elevated hearing threshold correlated significantly with experience of noise at the place of work, which was also elevated in the fibromyalgia group. Generalized pain had a high impact on the interaction between threshold of unpleasantness and daily noise experience. We interpret the differences in thresholds of hearing and of unpleasantness in patients with fibromyalgia as a form of either pre-conscious or conscious acts to protect against disturbing stimulation. Our results support the notion of a generalized disturbancy of perceptual thresholds in patients with fibromyalgia not restricted to the perception of pain.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 300-301 
    ISSN: 1434-4726
    Keywords: Cochlea ; Stria vascularis ; Vestibular organ (secretory epithelium) ; Autoradiography ; Menière's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atrial natriuretic peptide (ANP) is a cardiac hormone known to mediate increased capillary permeability, vasodilation, and natriuresis. Since specific receptors for ANP exist in both the eye and brain, possibly playing a role in ocular and cerebrospinal fluid regulation, we postulated that ANP might also be involved in inner ear fluid dynamics. Autoradiography was used to evaluate whether and where ANP receptors are present in the inner ear. Frozen sections of the cochlea and vestibular organ from guinea pigs (n=18) were incubated in either 125J-ANP alone or together with an excess of unlabeled ANP (as control). ANP receptors were demonstrated in the stria vascularis of the cochlea and in the secretory epithelium of the ampulla and the utriculus, but not in the region of the sensory cells. These results indicate that (1) specific ANP receptors are present in the inner ear, and (2) their local distribution is congruent with those parts thought to regulate labyrinthine fluid composition and volume. We speculate that ANP contributes to the homeostasis of the inner ear fluids and may even play a role in the pathophysiology of Menière's disease.
    Type of Medium: Electronic Resource
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