Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1076
    Keywords: Chronic granulomatous disease ; Aspergillosis ; Itraconazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An 11-year-old boy with chronic granulomatous disease caused by cytochrome b deficiency developed right upper lung lobe aspergillosis. Intracerebral lesions developed on maximum doses of flucytosine and amphotericin B. Treatment with 16 mg/kg oral itraconazole was followed by a dramatic clinical improvement and almost complete disappearance of the intracerebral lesions. Plasma itraconazole levels were between 40 and 3440 ng/ml depending on concomitant medication. Toxicity was restricted to transient elevation of alkaline phosphatase and gamma glutamyl transferase. We conclude that further trials with itraconazole are justified in high risk patients in whom conventional therapy has failed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 43 (1992), S. 131-136 
    ISSN: 1432-1041
    Keywords: Hydrazine ; Isoniazid ; Tuberculosis ; hepatotoxicity ; paediatric TB meningitis ; pulmonary TB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary An HPLC method is described for measurement of plasma hydrazine (Hz) concentrations (CHz) at the same time as isoniazid (INH) levels (CINH). Study has been made of CHz during 2–5 h after dose in healthy adults (A,n = 34), in adult pulmonary TB patients (B,n = 18) and in paediatric tuberculous meningitis patients (C,n = 25). Although the population has about equal proportions of ‘slow’ (52%) and ‘fast’ acetylators, in none of the groups could a correlation be shown between CHz levels or rates of Hz accumulation and any measure of acetylator type. Consequently Hz must be derived both from INH and from its metabolites during the first hours post-dose. For group A and ca. 70% of groups B and C a constant and maximal fraction of dose (ca. 0.6% for adults and 0.4% for paediatric patients) appeared as Hz at 4–5 h. For group B patients small pre-dose concentrations increased with duration of treatment. Four patients in group B showed the highest levels of CHz and rates of Hz accumulation some three times greater than the rest; all four had been identified as alcoholics and one showed evidence of hepatotoxicity at CHz (5 h) = 1.3% of dose. Amongst group C (9/25) episodes of high CHz 〉 0.5% of dose occurred during the first weeks of treatment and one developed CHz ca. 100 ng/ml = 1.3% of dose coincidentally with indications of hepatic damage.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Fibromyalgie ; generalisierter Schmerz ; Hörschwellen ; Wahrnehmungsstörung ; Key words Fibromyalgia ; widespread pain ; hearing threshold ; perceptual dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde geprüft, inwiefern sich Fibromyalgiepatienten nicht nur in der somatosensorischen, sondern auch in der Wahrnehmung und Verarbeitung externer Reize von Kontrollprobanden ohne generalisierte Schmerzen unterscheiden. Dazu wurden 30 Fibromyalgiepatienten mit 36 überwiegend schmerzfreien Kontrollprobanden hinsichtlich auditiver Wahrnehmungsleistungen verglichen. Die Gruppen waren nach Alter und dem Ausmaß hörorganisch nachweisbarer Schädigungen parallelisiert. Audiometrisch wurden Aversions- und Hörschwellen bestimmt. Zusätzlich machten die Teilnehmer Angaben zur Lärmerfahrung im Alltag, zur Vulnerabilität für Lärmstreß und zu fibromyalgieassoziierten Beschwerden. Die Ergebnisse zeigen bei Fibromyalgiepatienten die erwartete frequenzunabhängig reduzierte auditive Aversionsschwelle sowie im oberen Frequenzbereich einen asymptomatischen Hörverlust. Als gruppenübergreifend signifikantes Korrelat der Hörschwellenerhöhung erwies sich die selbstberichtete Lärmerfahrung am Arbeitsplatz, die bei Fibromyalgiepatienten erhöht war. Die Bewertung von Alltagslärm kovariierte ebenso wie die bewertungsabhängige auditive Aversionsschwelle mit der klinischen Schmerzausdehnung. Aversions- und Hörschwellendifferenzen werden als zwei Formen vorbewußter oder bewußter Methoden der Reizabschirmung bei Fibromyalgiepatienten interpretiert. Die Ergebnisse sprechen für eine nicht nur schmerzspezifische Störung der Reizverarbeitung. Erhöhte multilokuläre Druckschmerzhaftigkeit bei Fibromyalgie kann als eine von mehreren Manifestationen einer durch allgemeine Schwellenveränderungen und reduzierte Differenzierungsfähigkeit gekennzeichneten Reaktion auf externe Stimulation verstanden werden.
    Notes: Summary We examined to what extent patients with fibromyalgia differ from painfree control subjects in the perception and processing not only of somatosensory but also of external stimuli. For this purpose the acoustic perception of 30 patients with fibromyalgia was compared with that of 36 generally pain-free age and gender matched subjects. The groups were also controlled for organic disease of pathological dysfunction of the ear and auditory nerves. Thresholds of unpleasantness and hearing thresholds were determined autiometrically for various frequencies. In addition the participants rated their experience of daily noise, vulnerability to acoustic stress, and functional and affective complaints associated with fibromyalgia. As expected the results show reduced unpleasantness thresholds for all frequencies and a nonsymptomatic hearing loss for higher frequencies. The elevated hearing threshold correlated significantly with experience of noise at the place of work, which was also elevated in the fibromyalgia group. Generalized pain had a high impact on the interaction between threshold of unpleasantness and daily noise experience. We interpret the differences in thresholds of hearing and of unpleasantness in patients with fibromyalgia as a form of either pre-conscious or conscious acts to protect against disturbing stimulation. Our results support the notion of a generalized disturbancy of perceptual thresholds in patients with fibromyalgia not restricted to the perception of pain.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 33 (1985), S. 839-848 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 41 (1991), S. 677-688 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 35 (1987), S. 936 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 33 (1985), S. 839-848 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 41 (1991), S. 677-688 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 47 (1994), S. 1457-1458 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 35 (1987), S. 936 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...