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  • 1
    Electronic Resource
    Electronic Resource
    Complexation of fibronectin with tissue transglutaminase (1989)
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 628-635 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00428a032
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  • 2
    Electronic Resource
    Electronic Resource
    On the mechanism of aluminum via fill by reflow and forcefill as studied by transmission electron microscopy (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 571-577 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A comparison has been made between the Al via fill mechanisms in both reflow and forcefill processes. Cross-sectional transmission electron microscopy has been used to study the Al transport into the vias as a function of time. Our analysis shows that reflow and forcefill results can be explained by a stress relaxation model. We propose that the transport of aluminum into the vias as a function of time is described by both diffusion and dislocation movement. In the case of reflow at high temperature, the vias may be filled completely, after closure, by high-temperature creep of Al. In the case of forcefill, an additional high stress has been applied which raises the strain levels such to activate the dislocation glide and climb mechanism. The results from detailed investigations of the microstructure by cross-sectional transmission electron microscopy support these new insights. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.369491
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  • 3
    Electronic Resource
    Electronic Resource
    Electrophilic Bromination of 7-Norbornylidene-7'-Norbornane. The Observation of an Unusually Large Inverse Deuterium Kinetic Isotope Effect (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 8769-8776 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00139a009
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  • 4
    Electronic Resource
    Electronic Resource
    The Marl Slate: a model for the precipitation of calcite, dolomite and sulphides in a newly formed anoxic sea (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 34 (1987), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Detailed studies of a new, complete Marl Slate core in South Yorkshire have provided information on isotopic (δ13C, δ18O, δ34S) and geochemical variations (trace elements and C/S ratio) which enable the formulation of a model for carbonate and sulphide precipitation in the Late Permian Zechstein Sea. Calcite and dolomite are intimately associated; the fine lamination, organic character and absence of benthos in the sediments are indicative of anoxic conditions. Lithologically the core can be divided into a lower, predominantly sapropelic Marl Slate (2 m) and an upper Transition Zone (0·65 m) of alternating sapropel and calcite-rich and dolomite-rich carbonates.C/S ratios are 2·22 for the Marl Slate and 1·72 for the Transition Zone respectively, both characteristic of anoxic environments. δ18O in the carbonates shows a large and systematic variation closely mirrored by variations in calcite/dolomite ratio. The results suggest a fractionation factor equivalent to a depletion of 3·8% for 18O and 1·5% for 13C in calcite. The δ34S values of pyrite are isotopically light (mean value = - 32·7%) suggesting a fractionation factor for the Marl Slate of almost 44%, typical of anoxic basins.The results are related to stratification in the early Zechstein Sea. Calcite was precipitated in oxic upper layers above the halocline. Below the oxic/anoxic boundary framboidal pyrite was precipitated, resulting in lower sulphate concentration and elevated Mg/Ca ratio (due to calcite precipitation). As a result of this, dolomite formation occurred below the oxic/anoxic interface, within the anoxic water column and in bottom sediments. Variations in calcite/dolomite ratios, and isotopic variations, are thus explained by fluctuations in the relative level of the oxic/anoxic boundary in the Zechstein Sea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1987.tb00558.x
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  • 5
    Electronic Resource
    Electronic Resource
    A Cadmium(II) Complex of Creatinine, [Cd(C2H3O2)2(C4H7N3O)2].0.5H2O (1996)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 3043-3045 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196009833
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  • 6
    Electronic Resource
    Electronic Resource
    Tetraammonium Hexahydrogenhexamolybdozincate(II) Hexahydrate (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 7-9 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196011043
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  • 7
    Electronic Resource
    Electronic Resource
    Root squaring using level-index arithmetic (1989)
    Springer
    Computing 43 (1989), S. 171-185 
    Details
    ISSN: 1436-5057
    Keywords: 65G99 ; 65H05 ; Level-index ; symmetric level-index ; root-squaring ; polynomial equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Das “symmetrische Höhenindexsystem” (sli) zur Zahlendarstellung vereinfacht die Überwachung der Rechengenauigkeit und vermeidet overflow—oder underflow—Probleme. In dieser Arbeit werden die praktischen Vorzüge des Systems am Beispiel des Graeffeverfahrens vorgeführt.
    Notes: Abstract The symmetric level-index,sli, system for representing numbers eases the monitoring of precision while avoiding the problems associated with overflow and underflow. In this paper the practical benefits of the system are displayed, using the root-squaring method of Graeffe as a vehicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241860
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  • 8
    Electronic Resource
    Electronic Resource
    Small is beautiful (1988)
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 392-392 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To ANY molecular biologist who has the time to reflect, it will no doubt seem surprising that only a decade ago we were (blissfully?) unaware of the existence of the intervening sequences that are present in many of the genes of eukaryotic cells. What seems all the more amazing is how far we have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/334392b0
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  • 9
    Electronic Resource
    Electronic Resource
    MRT-gesteuerte regionale Tiefenhyperthermie (1999)
    Springer
    Der Radiologe 39 (1999), S. 756-763 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter MRT-Bildgebung ; Regionale Tiefenhyperthermie ; Weichteiltumoren ; Knochentumoren ; Key words MRI ; Regional hyperthermia ; Soft-tissue tumors ; Bone tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: Regional hyperthermia in combination with chemotherapy or/and radiotherapy is a promising treatment concept for locally advanced, deep-seated tumors. The purpose of the project is the optimization of the therapy using non-invasive, three-dimensional imaging of tissue changes or of the temperature distribution during regional hyperthermia. Methods: MRI offers methods suitable in principle for tissue characterization and MR thermometry. A new MRI-hyperthermia hybrid system has been developed based on an innovative hyperthermia applicator and an open MRI system. Results: After successful testing of the new MRI-hyperthermia hybrid system simultaneous MRI and regional hyperthermia in patients could be accomplished for the first time. At present the T1 relaxation time seems to be a promising parameter for MR thermometry. Conclusion: The first clinical application of the MRI-hyperthermia hybrid system can be regarded as an important step towards the development of regional hyperthermia. This new hybrid system and the MR thermometry methods have to be investigated prospectively in clinical studies.
    Notes: Zusammenfassung Fragestellung: Die regionale Tiefenhyperthermie in Kombination mit Chemotherapie und/oder Radiotherapie ist ein vielversprechendes Behandlungskonzept für lokal fortgeschrittene, tiefliegende Tumoren. Ziel dieses Projektes ist die nichtinvasive, dreidimensionale Darstellung der Gewebsveränderungen und der Temperaturverteilungen während der regionalen Tiefenhyperthermie. Methodik: Die Magnetresonanztomographie bietet prinzipiell geeignete Methoden für die Gewebecharakterisierung und für die MR-Thermometrie. Auf der Basis eines innovativen Hyperthermieapplikators und eines offenen MR-Tomographen wurde ein neues MRT-Hyperthermie-Hybridsystem entwickelt und erprobt. Ergebnisse: Nach der erfolgreichen Erprobung des neuen MRT-Hyperthermie-Hybridsystems an Phantomen und Probanden konnte erstmals am Patienten eine simultane MR-Bildgebung und Tiefenhyperthermie durchgeführt werden. Die T1-Relaxationszeit erscheint nach unseren derzeitigen Forschungsergebnissen ein vielversprechender Ansatz für die MR-Thermometrie bei 0,2 T zu sein. Schlußfolgerung: Der erstmalige klinische Einsatz des MRT-Hyperthermie-Hybridsystems kann als wichtiger Meilenstein für die Gesamtentwicklung der regionalen Tiefenhyperthermie bezeichnet werden. Das neue Gerät und die unterschiedlichen MRT-Verfahren, insbesondere die der MR-Thermometrie, müssen nun in klinischen Studien untersucht werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050572
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  • 10
    Electronic Resource
    Electronic Resource
    The relationship between theophylline clearance and age in adult life (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561019
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