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  • 1995-1999  (3)
  • 1980-1984
  • 1965-1969
  • B-cell lymphoma  (1)
  • Heparan sulphate  (1)
  • Key words: Statistical model, periodic seismicity, Kanto, stress release model, cluster.  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Pure and applied geophysics 155 (1999), S. 609-624 
    ISSN: 1420-9136
    Schlagwort(e): Key words: Statistical model, periodic seismicity, Kanto, stress release model, cluster.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract —A periodic pattern of seismicity has been reported for the Kinugawa cluster in the Kanto region, where several earthquake clusters are observed at depths between 40 and 90 km. To analyze this periodicity, statistical studies are performed for the Kinugawa cluster together with eight other clusters. Hypocentral parameters of the earthquakes with magnitudes 4.5 and larger for the period between 1950 and 1995 are taken from the JMA catalogue. The simple sinusoidal function, the exponential of sinusoidal function and the stress release model are applied as the intensity function. Model parameters are determined by the maximum likelihood method and the best model for each cluster is selected by using the Akaike Information Criterion (AIC). In six cases the sinusoidal model or the exponential of the sinusoidal model is selected as the best option and achieves AIC reductions of values between 2.4 and 13.2 units from the simple Poisson model. The stress release model is selected for two clusters. The three clusters, the Kinugawa, Kasumigaura, and Choshi clusters, have a similar optimal period of about 10 years, and align in the northwest–southeast direction at a similar depth range of 40 to 70 km. A model modified from the stress release model is applied to the three clusters so to analyze the relationship among them. In the modified model, an earthquake occurrence in one zone increases the stress in the other zone, which is different from the original stress release model which assumes a linear increase with time. Applying the modified model to the Kinugawa cluster, an AIC reduction from the Poisson model is significantly larger than the value obtained with the sinusoidal model. This suggests that the periodic seismicity observed for the Kinugawa cluster can be explained with the more comprehensive model than the sinusoidal model.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-2307
    Schlagwort(e): Basic fibroblast growth factor ; Heparan sulphate ; Beta-2-microglobulin ; Amyloidosis ; Haemodialysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A major constituent of the amyloid fibrils in dialysis-related amyloidosis is β2-microglobulin (β2-MG). Heparan sulphates (HS) co-localize with the amyloid fibrils and monocytes/macrophages are commonly found around amyloid deposits, but the role of HS in amyloidogenesis is not yet defined. HS have variable saccharide sequences and can interact specifically with basic fibroblast growth factor (bFGF), a potent chemotactic factor for the monocyte/macrophage. The present investigation was undertaken to look for a functional link between co-localized HS and the pathogenesis of dialysis-related amyloidosis. Using amyloid-enriched ligament, immunohistochemical localization was tested for β2-MG, endogenous bFGF, and bFGF-binding portions of HS. For the detection of bFGF-binding portions of HS, the ligament sections were incubated with exogenous bFGF and then with anti-bFGF antibody. The specificity of the interaction between bFGF and HS was established by confirming a concomitant loss of immunoreactivity during selective removal of HS with heparitinase. β2-MG, endogenous bFGF, and bFGF-binding portions of HS were detected between bundles of collagen. Endogenous bFGF and bFGF-binding portions of HS were not detected in more advanced amyloid lesions, whereas β2-MG and other portions of HS were detected. We propose that β2-MG, endogenous bFGF, and bFGF-binding portions of HS form a complex and localize in the early amyloid lesions of dialysis-related amyloidosis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-0584
    Schlagwort(e): Key words Hypercalcemia ; PTHrP ; B-cell lymphoma ; Bisphosphonate ; Kidney
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  A patient with primary non-Hodgkin's (B-cell type) lymphoma of the kidney developed hypercalcemia at the terminal stage of the disease. Although the plasma parathyroid hormone level was low, urinary cyclic AMP excretion was elevated. Serum osteocalcin (BGP) was suppressed and the plasma level of 1,25(OH)2D was within the normal range. Serum concentrations of PTH-related protein (PTHrP)-like immunoreactivity (PRP-LI) were elevated, and the tissue concentration of PRP-LI in the postmortem lymph node showed high level along with elevated serum PRP-LI, furthermore the production of PTHrP by the tumor was demonstrated by immunohistochemistry and Northern blotting analysis. These findings indicate that the hypercalcemia of the patient was caused by the PTHrP-producing B-cell lymphoma. Hypercalcemia was restored to normocalcemia by bisphosphonate treatment. Our case will add further information on humoral hypercalcemia in B-cell lymphoma, which rarely has been demonstrated to produce PTHrP.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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