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  • 11
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: As many as 50% of patients with reflux symptoms have no endoscopic evidence of oesophagitis. This multicentre study was designed to assess symptom relief after omeprazole 20 mg once daily in patients with symptoms typical of gastro-oesophageal reflux disease but without endoscopic evidence of oesophagitis. Methods: Patients (n=209) were randomized in a double-blind study to receive either omeprazole 20 mg once daily (n=98) or placebo (n=111) for 4 weeks. Symptoms were assessed at clinic visits and using daily diary cards, with patient-completed questionnaires providing additional data on symptoms and on psychological disturbance. Results: On completion, symptom relief favoured omeprazole: 57% of patients on omeprazole were free of heartburn (vs. 19% on placebo), 75% were free of regurgitation (47%) and 43% were completely asymptomatic (14%), each with P〈0.0001. Fewer patients in the omeprazole group required alginate/antacid relief medication (P〈0.05). Symptom relief (time to first heartburn-free day) was more rapid with omeprazole (2 vs. 5 days on placebo; P〈0.01). A greater reduction in anxiety occurred in the omeprazole group (P〈0.05). Conclusion: Omeprazole 20 mg once daily is effective in providing relief of the symptoms typical of gastro-oesophageal reflux disease in patients with essentially normal oesophageal mucosa.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by a progressive obliterating fibrosis of the intrahepatic and extrahepatic bile ducts. The pathogenesis of PSC is poorly understood but it is thought to be an immune-mediated disease. The optimal therapy which successfully improves symptoms, delays progression towards liver failure and transplantation and prevents the onset of cholangiocarcinoma remains elusive. Although current treatments are used to manage cholestasis and its consequences and some of the more general complications of the disease, none of the current therapeutic agents have been shown to retard and reverse the rate of disease progression. The role of cupruretics, corticosteroids, methotrexate, anti-fibrogenic agents and ursodeoxycholic acid in the treatment of PSC is reviewed. Orthotopic liver transplantation remains the only therapeutic option for advanced PSC but the timing of transplantation remains controversial and the possibility of recurrence of the disease in the graft is increasingly recognised. It is likely that greater insight into the pathogenetic mechanisms involved in PSC will allow therapy to be targetted more specifically at the biliary epithelium.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 507-507 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Insect Science and Its Application. Editor Thomas R.Odhiambo. 4/yr. (Pergamon.) £42.50, $48.57. NOT content with founding the International Centre for Insect Physiology and Ecology (ICIPE) in Nairobi, Professor Odhiambo has now started the first international entomological journal to ...
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 187 (1960), S. 960-961 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Crimp deterioration in fine Merino and Polwarth wools in changing from normal (1) to 'doggy' (3) In changing from normal to doggy, fine and medium Merino and Polwarth wools pass through an intermediate phase with secondary waves superimposed on the normal crimp ; in strong Merino wool the ...
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 37 (1981), S. 75-79 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1434-601X
    Keywords: PACS:23.20.Lv Gamma transitions and level energies – 27.80.+w 190 ≤ A ≤ 219 – 29.40.Ym Other detectors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The neutron deficient 199At nucleus has been studied in the 175Lu+28Si reaction at Eb= 141 MeV. In order to select events of interest in the presence of the very strong background caused by fission, γ-rays have been detected in coincidence with recoiling evaporation residues. The excited states of 199At observed for the first time may indicate that this nucleus is deformed.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1434-601X
    Keywords: 21.10.Re ; 21.60.Cs ; 23.20.Lv ; 27.50.+e
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The58Ni(30Si,αpn)82Y reaction at a beam energy of 134 MeV was used to populate the odd-odd nucleus82Y and coincidentγ rays depopulating high spin states in the evaporation residues were detected with the EUROGAM Phase 2 array. A superdeformed structure has been observed with an intensity of 1.5±0.5%. The cascade of 9 coincidentγ rays has consecutive energy spacing of ∼160 keV. This corresponds to a dynamic moment of inertia which is almost constant at approx mately 25h 2 MeV−1. The band is interpreted as a signature=0, negative parity SD band with aπ51 V52 intrinsic intruder configuration.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 6 (1999), S. 37-42 
    ISSN: 1434-601X
    Keywords: PACS: 23.20.Lv Gamma transitions and level energies – 27.70.+q 150 〈 A 〈 189
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: High-spin states in 167Hf, populated in the 141Pr(30Si, p3n)167Hf reaction, have been studied using the nordball Ge detector array. Three rotational cascades have been observed for the first time and the previously-known level scheme has been extended to significantly higher spin. Band-crossing effects are discussed within the framework of Woods-Saxon cranking calculations and are found to be in good agreement.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 30 (1981), S. 91-97 
    ISSN: 1570-7458
    Keywords: Tetranychus urticae ; Phytoseiids ; Fenvalerate ; Azinphosmethyl ; Mortality ; Sublethal effects ; Egg production ; Oviposition preference ; Repellency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Les insecticides pyrethroïdes ont été utilisés pour lutter contre les pullulations d'araignées rouges. Cette note examine les réponses de Tetranychus urticae Koch et des prédateurs phytoseiidés résistants aux organo-phosphorés, Amblyseius fallacis Garman et Typhlodromus occidentalis Nesbitt, au fenvalerate (pyrethroïde) et à l'azinphosmethyl (organophosphate). Quelques essais avec du carbaryl sont indiqués. Une femelle adulte de T. urticae est placée sur une rondelle de feuille de Phaseolus vulgaris L. pulvérisée dans une tour de Potter. Les résultats sur la mortalité en fonction de la dose obtenus montrent une activité plus rapide du fenvalerate que de l'azinphosmethyl. Les DL50 du fenvalerate (0,056 et 0,051g AI/I) sont les mêmes à 24 et 48 h, tandis que l'azinphosmethyl montre une activité plus lente (DL50 de 0,72 et 0,38g AI/I à 24 et 48 h). La mortalité se partage entre la sortie de la rondelle et la mortalité in situ. Le fenvalerate provoque une plus forte répulsion que l'azinphosmethyl. Contrairement à l'azinphosmethyl le fenvalerate inhibe la production d'oeufs 60% et 20% d'inhibition à DL50 au bout de 24 h par rapport au témoin. Cette inhibition n'est pas permanente. Le carbaryl n'a pas d'effets inhibiteur ou acaricide à 1g AI/l. Les femelles adultes de T. urticae décèlent les résidus de fenvalerate sur les rondelles et pondent leurs oeufs sur les moitiés non traitées ou traitées à l'azinphosmethyl. Les Phytoseiides sont très sensibles aux résidus de fenvalerate. Après consommation d'oeufs traités, A. fallacis est incapable d'éviter des bandes gluantes. T. occidentalis décèle des traitements à 0,00005g AI/l en quittant les lames traitées par les bandes gluantes.
    Notes: Abstract The pyrethroid fenvalerate showed significantly faster activity against adult ♀ two-spotted spider mite Tetranychus urticae Koch c.f. azinphosmethyl using broad bean leaf discs sprayed in a Potter tower. LC50s for fenvalerate were similar at 24 and 48 hr (0.056 and 0.051g AI/1) while LC50s for azinphosmethyl were significantly different at 24 and 48 hr (0.72 and 0.38g AI/1, respectively). Mortality was partitioned to run-off and direct mortality. Fenvalerate showed an increasing contribution to mortality by run-off with increasing concentration. Increasing concentrations of azinphosmethyl had no effect on the proportion of T. urticae running off the discs. Fenvalerate inhibited egg production c.f. azinphosmethyl (60% and 20% inhibition respectively c.f. control after 24hr). The effect was not permanent. Carbaryl showed no acaricidal or inhibitory effects at 1g AI/1. T. urticae detected fenvalerate residues as reflected by choice of oviposition sites on untreated halves of leaf discs c.f. treated halves. Azinphosmethyl had no effect on oviposition preference. Phytoseiid mites were highly sensitive to fenvalerate residues. Predators moved off the test arena into sticky barriers after feeding on fenvalerate-treated eggs or walking on glass slides treated at 0.00005g AI/1.
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 7 (1964), S. 1-8 
    ISSN: 1570-7458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Es wurde die Beziehung zweier Kohlfliegen-Populationen (Hylemyia brassicae Bouché) zu fäulniserregenden Bakterien an Kreuzblütlern in Verbindung mit dem von den Larven verursachten Schaden untersucht. 92 bez. 90% der Eier und 100 bez. 35% der Puparien, die sich an Kohlrüben und Chinakohl entwickelten, trugen pathogene Bakterien. Pathogene Kulturen wurden von 44% der Präpuppen-Häute aus Puparien der Chinakohl-Populationen erhalten. Die Larven vermochten fäulniserregende Bakterien wirksam auf gesunde Gewebe zu übertragen und förderten die Entwicklung und Ausbreitung der Fäule. Beim Schlüpfen waren die Imagines innerlich nicht stark kontaminiert, beschmierten sich aber offenbar äußerlich durch Kontakt mit dem Inneren der Puppengehäuse und der Präpuppen-Häute. Ein als Erwinia spec. identifizierter Bakterientyp konnte durchgängig von allen Stadien der Kohlfliege isoliert werden, die sich an Kohlrüben entwickelten. Er verursacht bei Kohlrüben eine langsame nekrotische Fäulnis und dunkle Verfärbung der befallenen Gewebe. Dieses Bakterium scheint antagonistisch zu anderen Bakterien zu sein, da nur sehr wenige andere Keime mit Stadien der Insekten dieser Population vergesellschaftet gefunden wurden. Umgekehrt fanden sich viele verschiedene Bakterientypen auf Stadien der auf dem Chinakohl lebenden Kohlfliegen. Die Virulenz der pathogenen Kulturen variierte beträchtlich, jedoch verursachten alle irgendeine Art der Weichfäule. Einige dieser aus dem Inneren oberflächlich sterilisierter Puparien isolierten Kulturen wurden als Pseudomonas spec. and Aerobacter spec. bestimmt. Die Art der bakteriellen Kontamination der Kohlfliege scheint hauptsächlich von der Empfänglichkeit ihrer kreuzblütigen Wirtspflanzen gegenüber verschiedenen Typen der Fäulnis nach Verletzung durch die Kohlfliegenmaden abhängig zu sein. Die allgemeinen Zusammenhänge zwischen dem Insekt und den fäulniserregenden Bakterien werden beschrieben.
    Notes: Abstract Bacteria pathogenic to crucifers were isolated from 92% of the eggs from flies of the cabbage maggot, Hylemyia brassicae (Bouché) of a population from rutabaga (Swede; Brassica napus napobrassica) and from 90% of those from a population from Chinese cabbage (Brassica pekinensis). The larvae transmitted the decay-causing bacteria to healthy tissues and aided in the development and spread of the rot. Of bacterial isolates from the interior of surface-sterile puparia, decay was caused by 100% of those from the rutabaga population and 35% of those from Chinese cabbage. Pathogenic cultures were also obtained from 44% of the prepupal linings of the Chinese cabbage population. The light internal contamination of adults at eclosion showed that the flies became contaminated externally from the interior of the puparia. The two populations of H. brassicae studied were contaminated with distinctly different types of bacteria. Erwinia sp., the predominant isolate from the rutabaga population, grew best on rutabaga. It caused a slow necrotic collapse and a dark pigmentation of the tissues, but not a soft-rot. Many different types of bacterial contaminants were associated with the stages of the cabbage maggot from Chinese cabbage. Green pigmenting, non-pathogenic forms were very prevalent. All pathogenic cultures caused some type of soft-rot. Some of these cultures were identified as Pseudomonas sp. and Aerobacter sp.
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