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  • 1995-1999  (1)
  • 1980-1984  (1)
  • Body fat  (1)
  • Chlorthalidone  (1)
  • 1
    ISSN: 1433-2965
    Keywords: Bone loss ; Chlorthalidone ; Clinical trial ; Thiazide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Employing a double-masked, prospective design, bone loss at three skeletal sites has been monitored among 113 postmenopausal women participating in a placebo-controlled trial of the thiazide-like diuretic chlorthalidone for treatment of systolic hypertension. The mean duration of chlorthalidone use was 2.6 years, at doses of 12.5–25 mg/day. Compared with placebo use, chlorthalidone use was associated with significant reductions in annual bone loss rates. Non-use of chlorthalidone was associated with bone loss at the calcaneus (−0.56% per year) and the proximal radius (−0.91% per year); borderline bone gain was observed at the distal radius (+0.39%). In contrast, chlorthalidone use was associated with bone gain at the calcaneus (+0.44% per year) and the distal radius (+1.51% per year); proximal radius bone loss was significantly reduced to −0.32% per year. The average increment for three appendicular sites was +0.9% per year. These data support a causal relationship between chlorthalidone use and reduced bone loss.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 50 (1983), S. 319-329 
    ISSN: 1439-6327
    Keywords: Maximum aerobic capacity ; Dietary-induced thermogenesis ; Body fat ; Resting metabolic rate ; Luxuskonsumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Resting metabolic rate (RMR), dietary thermogenesis (DIT), aerobic capacity ( $$\dot V$$ O2 max), and percent body fat were measured in a group of sixteen women and ten men. DIT was significantly positively correlated with aerobic capacity (r=0.658). Percent body fat was significantly negatively correlated with $$\dot V$$ O2 max (r=−0.727). RMR was independent of $$\dot V$$ O2 max, or body fatness, but women had a significantly higher average RMR than men. Three men and three women participated in an endurance training program which significantly increased $$\dot V$$ O2 max. DIT was increased in proportion to the increase in aerobic capacity (r s=0.924), RMR was unchanged, and body fat decreased in males but not females. The controversy surrounding “luxuskonsumption” may stem in part from not taking into account individual differences in aerobic capacity when measuring DIT.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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