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  • 1995-1999  (2)
  • 1980-1984
  • Human  (1)
  • Key words. Trehalose 6,6′-dimycolate (TDM); cord factor; mycolic acid; granuloma formation; Mycobacterium; gas chromatography-mass spectrometry.  (1)
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Material
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  • 1995-1999  (2)
  • 1980-1984
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Granuloma formation activity and mycolic acid composition of mycobacterial cord factor (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 227-232 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Trehalose 6,6′-dimycolate (TDM); cord factor; mycolic acid; granuloma formation; Mycobacterium; gas chromatography-mass spectrometry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. We analyzed the mycolic acid composition of trehalose 6,6′-dimycolate (TDM) obtained from Mycobacterium, using thin layer chromatography, gas chromatography and gas chromatography-mass spectrometry. Utilizing TDM, whose structure was confirmed, granuloma formation in mice was investigated. All TDM used exhibited considerable granuloma formation activity in the lung and spleen. In particular, TDM from M. bovis showed the greatest activity and toxicity among mycobacterial TDM. We therefore discussed the relationship between the chemical structure and granuloma-forming activity of TDM, especially in relation to the structure of mycolic acid in TDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000595
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Elevation of serum human hepatocyte growth factor (HGF) level in patients with pneumonectomy during a perioperative period (1998)
    Springer
    Intensive care medicine 24 (1998), S. 434-437 
    Details
    ISSN: 1432-1238
    Keywords: Key words Hepatocyte growth factor (HGF) ; Pneumonectomy ; Lung growth ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Proliferation of alveolar type II cells is thought to be critical for the restoration of lung function after diffuse alveolar damage or pneumonectomy. However, the factors that regulate alveolar type II cell proliferation, and the mechanism that brings about compensatory lung growth are not well understood. Hepatocyte growth factor (HGF) has been shown to have hepatotrophic and nephrotrophic functions for regeneration of the liver and kidney. We have attempted to investigate the involvement of HGF in lung regeneration after lung resection. Desgin: A prospective, controlled study. Setting: Adult surgical patients in a university hospital. Patients and measurements: We measured serum HGF levels in eight patients undergoing major lung resection, and in five patients undergoing mastectomy as controls, by using radioimmunoassay and an enzyme-linked immunosorbent assay. Results: In all cases of pneumonectomy, the serum HGF levels increased 3- to 5-fold at 1–3 days (with a peak at 3 days) after operation, and then decreased to nearly basal levels in 2 weeks. However, these levels in patients undergoing mastectomy did not change much over the first 2 weeks, postoperatively. Conclusions: Serum HGF levels increased in patients after major lung resection, which suggests that HGF might play an important role in lung regeneration or compensatory lung growth in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050592
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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