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  • 1995-1999  (2)
  • 1980-1984
  • Integrin receptors  (1)
  • hydrogen peroxide  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides (1998)
    Springer
    Journal of molecular medicine 76 (1998), S. 126-132 
    Details
    ISSN: 1432-1440
    Keywords: Key words c-Myb antisense oligodeoxynucleotides ; Cell proliferation ; HIV-1 ; Integrin receptors ; Transfer peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Integrin receptor-targeted transfer of oligodeoxynucleotides (ODNs) by small synthetic peptides was used for improving delivery of antisense ODNs. An 18-mer phosphodiester bond containing ODN complementary to c-myb-encoded mRNA was complexed with several transfer peptides, containing as their parts two modules: (a) an RGD-motif as targeting sequence for integrin receptor and (b) nucleocapsid protein (NCp) 7 of HIV-1 or NCp7-derived peptides for complex formation with the ODNs. The amount of antisense ODN required for the inhibition of proliferation of human myeloid cell line HL-60 in vitro can be more than 50-fold reduced by complexing with transfer peptides. The efficiency of antisense delivery was increased by multimerization of the targeting sequence for the integrin receptor. Competition with integrin peptide abolished the effect, indicating that the integrin receptor is indeed responsible for the reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050200
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Generation of H2O2 by Human Neutrophils and Changes of Cytosolic Ca2+ and pH of Rat Thymocytes in Response to Galactoside-Binding Proteins (Lectins or Immunoglobulins) (1997)
    Springer
    Bioscience reports 17 (1997), S. 219-230 
    Details
    ISSN: 1573-4935
    Keywords: Endogenous lectins ; galectins ; hydrogen peroxide ; biosignaling pathways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In contrast to plant agglutinins, biological activities of animal/human lectins are not well defined yet. Testing a panel of seven mammalian carbohydrate-binding proteins we have found that the dimeric lectin from chicken liver (CL-16) was a stimulator of H2O2 release from human neutrophils as well as effector for induction of cytosolic Ca2+ and pH increase in rat thymocytes. Activity of this lectin was comparable to potent galactoside-specific plant lectins such as Viscum album L. agglutinin. The activities of the tested plant lectins depended significantly on their nominal carbohydrate specificity as well as on the source. The results indicate that endogenous lectins may be involved in the regulation of neutrophil and lymphocyte functions by elicitation of selective biosignaling reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027389614391
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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