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  • 1
    Electronic Resource
    Electronic Resource
    Thermal behaviour of uranium(VI) complexes (1983)
    Springer
    Journal of thermal analysis and calorimetry 28 (1983), S. 227-236 
    Details
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wurde versucht, Komplexe von Uranylacetat undN-phenylthioharnstoff in fester Phase durch Erhitzen verschiedener stöchiometrischer Gemische der Reaktanten direkt in einer DSC- und einer TA-Apparatur herzustellen. Sowohl die DSC- als auch die TG-Ergebnisse deuten darauf hin, dass nur das 1∶1-Addukt gebildet wird, und zwar unabhängig von den molaren Mischungsverhältnissen der Reaktanten. Übereinstimmend mit IR-Daten scheint die Reaktion nur bei einem grossen Überschuss anN-Phenylthioharnstoff vollständig zu verlaufen.
    Abstract: Резюме Предприняты попытки твердотельных синте зов комплексов уранилац етата с N-фенилтиомочевиной н агреванием их непоср едственно в приборах ДСК и ТА. Уста новлено, что независимо от мол ярного соотношения в зятых реагентов, всегда пол учали аддукт состава 1:1. Согласно дан ным ИК спектроскопии, реакция протекает полностью только в присутствии значит ельного избытка N-фенилтиомочевины.
    Notes: Abstract The solid-state syntheses of complexes of uranyl acetate dihydrate andN-phenylthiourea have been attempted by heating various stoichiometric mixtures of the reactants directly in a DSC and in a TA apparatus. Both the DSC and the TG results indicate that only the 1∶1 adduct is formed, independently of the molar ratios of the reactants. It appears that the reaction is complete only with a large excess ofN-phenylthiourea, in agreement with IR data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983256
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  • 2
    Electronic Resource
    Electronic Resource
    Increased activity of the insulin-like growth factor system in mesangial cells cultured in high glucose conditions. Relation to glucose-enhanced extracellular matrix production (1996)
    Springer
    Diabetologia 39 (1996), S. 775-784 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-like growth factor-I ; II ; binding proteins ; receptors ; transforming growth factor-b ; extracellular matrix ; mesangial cell ; diabetes mellitus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent evidence suggests that several growth factors participate in diabetic glomerular disease by mediating increased extracellular matrix accumulation and altered cell growth and turnover leading to mesangial expansion. Transforming growth factor (TGF)-β has been demonstrated to be upregulated both in vivo and in vitro, whereas studies on the activity of the renal insulin-like growth factor (IGF) system in experimental diabetes have provided conflicting results. We investigated the effects of prolonged exposure (4 weeks) of cultured human and rat mesangial cells to high (30 mmol/l) glucose vs iso-osmolar mannitol or normal (5.5 mmol/l) glucose levels on: 1) the autocrine/paracrine activity of the IGF system (as assessed by measuring IGF-I and II, IGF-I and II receptors, and IGF binding proteins); and, in parallel, on 2) TGF-β1 gene expression; 3) matrix production; and 4) cell proliferation. High glucose levels progressively increased the medium content of IGF-I and the mRNA levels for IGF-I and IGF-II, increased IGF-I and IGF-II binding and IGF-I receptor gene expression, and reduced IGF binding protein production. TGF-β1 transcripts and matrix accumulation and gene expression were increased in parallel, whereas cell proliferation was reduced. Iso-osmolar mannitol did not affect any of the above parameters. These experiments demonstrated that high glucose levels induce enhanced mesangial IGF activity, together with enhanced TGF-β1 gene expression, increased matrix production, and reduced cell proliferation. It is possible that IGFs participate in mediating diabetes-induced changes in matrix turnover leading to mesangial expansion, by acting in a paracrine/autocrine fashion within the glomerulus. [Diabetologia (1996) 39: 775–784]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050510
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  • 3
    Electronic Resource
    Electronic Resource
    Regulatory role of eicosanoids in extracellular matrix overproduction induced by long-term exposure to high glucose in cultured rat mesangial cells (1996)
    Springer
    Diabetologia 39 (1996), S. 1055-1062 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Extracellular matrix ; transforming growth factor-β ; prostaglandins ; thromboxane ; mesangial cell ; diabetes mellitus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Accumulation of extracellular matrix in the mesangium and altered renal eicosanoid synthesis are two prominent features of diabetic glomerular disease. We investigated the relationship between eicosanoid and extracellular matrix production in rat mesangial cells cultured under high glucose vs normal glucose conditions. Long-term exposure of rat mesangial cells to high glucose, but not to iso-osmolar mannitol, significantly increased extracellular matrix accumulation and gene expression and transforming growth factor-β (TGF-β) mRNA levels, and decreased prostaglandin (PG) E2 synthesis without affecting production of either thromboxane (TX) B2 or PGF2 a, with respect to cells incubated in normal glucose. Addition of exogenous PGE2 resulted in a dose-dependent reduction of matrix protein and mRNA levels and TGF-β gene expression in cells cultured in either normal or high glucose conditions, whereas exposure to exogenous PGF2α produced a significant increment in matrix production and matrix and TGF-β gene expression in cells grown in normal glucose, but only a slight increase in those cultured in high glucose. Stimulation of endogenous endoperoxide metabolism towards PGE2 and PGF2α synthesis with FCE-22,178, a drug originally developed as TXA2 synthase inhibitor, resulted in a dose-dependent decrease in matrix accumulation and matrix and TGF-β gene expression which was suppressed by co-incubation with the cyclo-oxygenase inhibitor fenoprofen blocking the FCE-22,178-enhanced PG production. In both cell lines, the rate of synthesis of TXA2 was very low and the selective blockade of its synthesis (by two other TXA2 synthase inhibitors, OKY-046 and Ridogrel) or action (by the TXA2 receptor antagonist BM-13,177) did not alter matrix production or TGF-β mRNA levels. These results suggest that the cyclo-oxygenase pathway is involved in the regulation of matrix changes induced by high glucose in rat mesangial cells; the reduced production of PGE2 may enhance the synthesis or potentiate the effect of stimulators of ECM formation such as TGF-β, whereas TXA2 does not appear to be involved. These data also indicate that glucose-enhanced mesangial matrix accumulation may be prevented by exogenous PGE2 or by drugs capable of increasing endogenous PGE2 synthesis. [Diabetologia (1996) 39: 1055–1062]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400654
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  • 4
    Electronic Resource
    Electronic Resource
    Regulatory role of eicosanoids in extracellular matrix overproduction induced by long-term exposure to high glucose in cultured rat mesangial cells (1996)
    Springer
    Diabetologia 39 (1996), S. 1055-1062 
    Details
    ISSN: 1432-0428
    Keywords: Extracellular matrix ; transforming growth factor-Β ; prostaglandins ; thromboxane ; mesangial cell ; diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Accumulation of extracellular matrix in the mesangium and altered renal eicosanoid synthesis are two prominent features of diabetic glomerular disease. We investigated the relationship between eicosanoid and extracellular matrix production in rat mesangial cells cultured under high glucose vs normal glucose conditions. Long-term exposure of rat mesangial cells to high glucose, but not to iso-osmolar mannitol, significantly increased extracellular matrix accumulation and gene expression and transforming growth factor-Β (TGF-Β) mRNA levels, and decreased prostaglandin (PG) E2 synthesis without affecting production of either thromboxane (TX) B2 or PGF2α, with respect to cells incubated in normal glucose. Addition of exogenous PGE2 resulted in a dose-dependent reduction of matrix protein and mRNA levels and TGF-Β gene expression in cells cultured in either normal or high glucose conditions, whereas exposure to exogenous PGF2α produced a significant increment in matrix production and matrix and TGF-Β gene expression in cells grown in normal glucose, but only a slight increase in those cultured in high glucose. Stimulation of endogenous endoperoxide metabolism towards PGE2 and PGF2α synthesis with FCE-22,178, a drug originally developed as TXA2 synthase inhibitor, resulted in a dose-dependent decrease in matrix accumulation and matrix and TGF-Β gene expression which was suppressed by co-incubation with the cyclo-oxygenase inhibitor feno-profen blocking the FCE-22,178-enhanced PG production. In both cell lines, the rate of synthesis of TXA2 was very low and the selective blockade of its synthesis (by two other TXA2 synthase inhibitors, OKY-046 and Ridogrel) or action (by the TXA2 receptor antagonist BM-13,177) did not alter matrix production or TGF-Β mRNA levels. These results suggest that the cyclo-oxygenase pathway is involved in the regulation of matrix changes induced by high glucose in rat mesangial cells; the reduced production of PGE2 may enhance the synthesis or potentiate the effect of stimulators of ECM formation such as TGF-Β, whereas TXA2 does not appear to be involved. These data also indicate that glucose-enhanced mesangial matrix accumulation may be prevented by exogenous PGE2 or by drugs capable of increasing endogenous PGE2 synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400654
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  • 5
    Electronic Resource
    Electronic Resource
    SH2D1A mutation analysis for diagnosis of XLP in typical and atypical patients (1999)
    Springer
    Human genetics 〈Berlin〉 105 (1999), S. 501-505 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency to Epstein-Barr virus (EBV). The gene responsible for XLP has recently been identified as the four-exon SH2D1A gene encoding a 128-amino-acid protein that contains an SH2-domain. Functional studies indicate the SH2D1A protein acts as a regulator of at least two signal transduction pathways initiated by the cell surface molecules SLAM and 2B4, respectively, and possibly related to the host immune response to EBV infection. We have carried out a systematic mutation study of the SH2D1A gene in our series of 19 typical and 8 atypical XLP patients by polymerase chain reaction (PCR), reverse transcription/PCR, and sequencing, and have reconstructed the haplotypes of the patients. Four out of the 13 mutations detected are previously unreported. The identification of SH2D1A mutations in carriers from all three XLP families screened and the detection of mutations in two out of eight atypical patients indicates the usefulness of a DNA-based diagnosis for XLP disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004399900168
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  • 6
    Electronic Resource
    Electronic Resource
    Jet production in highQ 2 deep-inelastic ep scattering at HERA (1995)
    Springer
    The European physical journal 67 (1995), S. 81-92 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Two-jet production in deep-inelastic electron-proton scattering has been studied for 160〈Q 2〈1280 GeV2, 0.01〈x〈0.1 and 0.04〈y〈0.95 with the ZEUS detector at HERA. The kinematic properties of the jets and the jet production rates are presented. The partonic scaling variables of the two-jet system and the rate of two-jet production are compared to perturbative next-to-leading order QCD calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01564823
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement of multiplicity and momentum spectra in the current fragmentation region of the Breit frame at HERA (1995)
    Springer
    The European physical journal 67 (1995), S. 93-107 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Charged particle production has been measured in Deep Inelastic Scattering (DIS) events using the ZEUS detector over a large range ofQ 2 from 10 to 1280 GeV2. The evolution withQ of the charged multiplicity and scaled momentum has been investigated in the current fragmentation region of the Breit frame. The data are used to study QCD coherence effects in DIS and are compared with correspondinge + e − data in order to test the universality of quark fragmentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01564824
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement of the proton structure functionF 2 from the 1993 HERA data (1995)
    Springer
    The European physical journal 65 (1995), S. 379-398 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The ZEUS detector has been used to measure the proton structure functionF 2. During 1993 HERA collided 26.7 GeV electrons on 820 GeV protons. The data sample corresponds to an integrated luminosity of 0.54 pb−1, representing a twenty fold increase in statistics compared to that of 1992. Results are presented for 7〈Q 2〈104 GeV2 andx values as low as 3×10−4. The rapid rise inF 2 asx decreases observed previously is now studied in greater detail and persists forQ 2 values up to 500 GeV2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556128
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  • 9
    Electronic Resource
    Electronic Resource
    A search for excited fermions in electron-proton collisions at HERA (1995)
    Springer
    The European physical journal 65 (1995), S. 627-647 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A search for excited states of the standard model fermions was performed using the ZEUS detector at the HERA electron-proton collider, operating at a centre of mass energy of 296 GeV. In a sample corresponding to an integrated luminosity of 0.55 pb−1, no evidence was found for any resonant state decaying into final states composed of a fermion and a gauge boson. Limits on the coupling strength times branching ratio of excited fermions are presented for masses between 50 GeV and 250 GeV, extending previous search regions significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578671
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  • 10
    Electronic Resource
    Electronic Resource
    Dijet cross sections in photoproduction at HERA (1998)
    Springer
    The European physical journal 1 (1998), S. 109-122 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Dijet cross sections are presented using photoproduction data obtained with the ZEUS detector during 1994. These measurements represent an extension of previous results, as the higher statistics allow cross sections to be measured at higher jet transverse energy (E τ jet ). Jets are identified in the hadronic final state using three different algorithms, and the cross sections compared to complete next-to-leading order QCD calculations. Agreement with these calculations is seen for the pseudorapidity dependence of the direct photon events with E T jet 〉 6 GeV and of the resolved photon events with E t jet 〉 11 GeV. Calculated cross sections for resolved photon processes with 6 GeV 〈 E T jet 〈 11 GeV lie below the data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245801
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