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  • 1995-1999  (5)
  • 1975-1979  (7)
  • 1915-1919
  • 1890-1899
  • Analytical Chemistry and Spectroscopy  (10)
  • Cholecystokinin
  • 1
    Electronic Resource
    Electronic Resource
    Electrophysiological studies of the cholecystokininA receptor antagonists SR27897B and PD140548 in the rat isolated nodose ganglion (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 693-697 
    Details
    ISSN: 1432-1912
    Keywords: Rat nodose ganglion ; Cholecystokinin ; Depolarisation ; Receptor subtypes ; Receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With increased interest in the pharmacology of cholecystokininA (CCKA) receptors, including their trophic and mitogenic effects, the actions of two new non-peptide CCKA receptor antagonists, PD140548 and SR 2789713, were investigated in a convenient model system, the rat isolated nodose ganglion. CCK (1 nM-1 μM) caused concentration-dependent depolarisations when superfused over the nodose ganglion at 37° C as measured by a silicone grease gap technique, and both CCKA antagonists caused significant rightward shifts in the concentration response curve to CCK. SR 2789713 (3 and 10 nM) caused 7.9-and 17.9-fold shifts in the CCK concentration-response curve and the apparent — log KB values for each concentration of antagonist were calculated to be 9.36 and 9.23. Further experiments with PD140548 (30 and 100 nM) yielded shifts of 2.9- and 12.5-fold from which — log KB values were determined to be 7.80 and 8.06. Overall SR 2789713 was significantly more efficacious than PD140548. Thus, the isolated nodose ganglion preparation allows a functional assessment of CCKA-mediated responses, with the results indicating that both SR 27897B and PD 140548 are efficacious CCKA receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167190
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Electrophysiological studies of the cholecystokininA receptor antagonists SR 27897B and PD140548 in the rat isolated nodose ganglion (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 693-697 
    Details
    ISSN: 1432-1912
    Keywords: Key words Rat nodose ganglion ; Cholecystokinin ; Depolarisation ; Receptor subtypes ; Receptor antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  With increased interest in the pharmacology of cholecystokininA (CCKA) receptors, including their trophic and mitogenic effects, the actions of two new non-peptide CCKA receptor antagonists, PD140548 and SR 27897B, were investigated in a convenient model system, the rat isolated nodose ganglion. CCK (1 nM–1 μM) caused concentration-dependent depolarisations when superfused over the nodose ganglion at 37° C as measured by a silicone grease gap technique, and both CCKA antagonists caused significant rightward shifts in the concentration response curve to CCK. SR 27897B (3 and 10 nM) caused 7.9- and 17.9-fold shifts in the CCK concentration-response curve and the apparent −log KB values for each concentration of antagonist were calculated to be 9.36 and 9.23. Further experiments with PD140548 (30 and 100 nM) yielded shifts of 2.9- and 12.5-fold from which −log KB values were determined to be 7.80 and 8.06. Overall SR 27897B was significantly more efficacious than PD140548. Thus, the isolated nodose ganglion preparation allows a functional assessment of CCKA-mediated responses, with the results indicating that both SR 27897B and PD140548 are efficacious CCKA receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167190
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tris (2,2′-bipyridyl)ruthenium (III) as a chemiluminescent reagent for detection in capillary electrophresis (1997)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 20 (1997), S. 643-646 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrophoresis ; Electogenerated chemiluminescence ; Ru(bpy)32+ ; Tripropylamine ; Proline ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A post- column chemiluminescent technique for thedetection of compounds that are poor chromoshores using electorogenerated chemiluminescence following separation by capillartgy electrophoresis is described. The luminrescent signal is generated followintg the reaction of anlyres (e.g. amines) with Ru(bpy)33+, which isx electrochemically generated post-columan from Ru(bpy)32+. Tripropylamine and proline are used as two model compounds to demostrate the feasibility of the method. Detection limits for the prototype system were in the micromolar rage, suggesting that this technnique offers an alternative to indirect detection of compounds that are poor chromophores with an added selectivity advangage. The system includes the use of a conductive joint to isolate the separation field from the potential necessary to drive the elctrogenerated chemiluminescent reactiion. Addition of the chemiluminescent reagent Ru(bpy)32+ post-column did not decrease the efficiency of the separation. The design and favrication of the novel cell is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240201205
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mass fragmentographic determination of unlabeled and deuterium labeled methadone in human plasma. Possibilities for measurement of steady state pharmacokinetics (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 197-200 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A mass fragmentographic method for simultaneous measurement of unlabeled and deuterium labeled methadone in human plasma is described. This specific method has a lower sensitivity of about 16 pmol/ml with a coefficient of variation of less than 4%. The usefulness of the method was evaluated in studies on opiate dependent subjects undergoing methadone maintenance treatment. In one application methadone-d3 was given as a pulse dose during continuous treatment with unlabeled methadone and plasma levels of both species followed by mass fragmentography. The method will be of value in the study of methadone pharmacokinetics in the steady state and in other in vivo situations where multiple drug pools must exist.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020406
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Simultaneous estimation of propoxyphene-d0 and propoxyphene-d2 levels by quantitative mass fragmentography. Potential utility in multidose investigations (1976)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 3 (1976), S. 212-216 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A quantitative mass fragmentographic method for the simultaneous determination of labeled and unlabeled propoxyphene in plasma is described. Dogs treated daily with propoxyphene-d0 were treated with a pulse dose of propoxyphene-d2 at day 20. It was found that following an initial rapid equilibrium phase levels of propoxyphene-d2 fell more rapidly than those of propoxyphene-d0. This result suggests that ‘deep’ pools of tissue bound propoxyphene exist which exchange very slowly with drug present in the central compartment. Experimental evidence is presented which demonstrates that the difference in behavior of propoxyphene-d0 and -d2 is not due to unanticipated secondary isotope effects.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200030504
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  • 6
    Electronic Resource
    Electronic Resource
    Propoxyphene: Pathways of metabolism in man and laboratory animals (1976)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 3 (1976), S. 217-225 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Through the combined use of stable isotope labeling and gas chromatographic mass spectrometric analysis, the metabolic patterns for propoxyphene have been determined in laboratory animals and man. The rat and dog eliminated propoxyphene and its metabolites principally via the bile, while the rabbit more closely resembled man in excreting the metabolic products into urine. Metabolites in rat and rabbit existed as conjugates, whereas in dog and man the metabolites were excreted as a mixture of the free and unconjugated forms. The primary route of metabolism in all species studied was N-demethylation. However, the rat and rabbit extensively hydroxylated propoxyphene and its metabolltes prior to elimination. Metabolites arising from ester hydrolysis were found in rat and man. N-acetylated products were identified in all four species. A metabolite formed from cyclization and dehydration of dinorpropoxyphene was isolated in urine and was further identified as a circulating metabolite in dog plasma.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200030505
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Rapid analysis of environmental samples using solid-phase microextraction (SPME) and narrow bore capillary columns (1995)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 18 (1995), S. 495-499 
    Details
    ISSN: 0935-6304
    Keywords: SPME ; Capillary columns ; Volatile organic compounds ; Purge and trap ; Chlorinated pesticides ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The application of SPME, a solventless extraction procedure, is demonstrated for two environmental applications. Extraction of VOCs by SPME is coupled with analysis on short narrow bore capillary gas chromatography columns. The technique is shown both as a fast screening tool and as part of an analytical procedure when combined with a mass spectrometer. Data show the linear range of the procedure. The extraction of chlorinated pesticides from hazardous wastewater and drinking water by SPME is also described in this paper. SPME is compared to traditional extraction procedures with respect to cost, time, ease of use, solvent usage, and sample usage.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240180807
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  • 8
    Electronic Resource
    Electronic Resource
    15N nuclear magnetic resonance spectroscopy. Natural-abundance 15N spectra of aliphatic oximesSupported by the Public Health Service, Research Grant No. GM-11073, from the Division of General Medical Sciences, and by the National Science Foundation. (1978)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 11 (1978), S. 510-515 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 15N chemical shifts of the Z and E isomers of twenty-two ketoximes and fourteen aldoximes have been determined at the natural-abundance level of 15N, using Fourier transform methods. The influences of π delocalization, methyl substituents and solute concentration on the oxime nitrogen shielding have been determined. The 15N shifts for oximes of several cycloalkanones have been measured and the influence of ring size on the chemical shifts is discussed.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270111008
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  • 9
    Electronic Resource
    Electronic Resource
    Mass spectra of a series of 2-p-substituted phenyl-1,3,2-dioxaborolanes (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 13 (1978), S. 425-428 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of a series of 2-p-substituted phenyl-1,3,2-dioxaborolanes have been examined and compared with the mass spectrum of 2-phenyl-1,3,2-dioxaborolane. Formation of the substituted ion [C7H6X]+ by electron impact induced rearrangement has been found to be influenced significantly by the presence and nature of the substituent at the para position of the phenyl ring.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210130711
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  • 10
    Electronic Resource
    Electronic Resource
    Unresolvable long range spin-spin coupling as a source of systematic error in proton NMR total bandshape analysis (1975)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 7 (1975), S. 307-308 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Unresolvable long range spin-spin coupling which is not explicitly taken into account in total NMR bandshape analysis is demonstrated to be a potentially important source of systematic error, leading to ΔH≠ and δS≠ values incorrect by c. 1 kcal/mol and 2 to 4 cal/(mol K), respectively.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270070702
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