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  • 1
    Electronic Resource
    Electronic Resource
    Degradation of aromatic carboxylic acids by Nocardia spec. DSM 43251 (1979)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 5 (1979), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1979.tb03314.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cometabolism of phenol and substituted phenols by nocardia spec. DSM 43251 (1979)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 5 (1979), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1979.tb03343.x
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  • 3
    Electronic Resource
    Electronic Resource
    Chondroneutrality of meloxicam in rats with spontaneous osteoarthrosis of the ankle joint (1997)
    Springer
    Zeitschrift für Rheumatologie 56 (1997), S. 21-30 
    Details
    ISSN: 0340-1855
    Keywords: Key words Meloxicam ; non-steroidal anti-inflammatory drug ; rats ; osteoarthrosis of ankle joints ; histology ; Schlüsselwörter Meloxicam ; nichtsteroidales Antiphlogistikum ; Ratten ; Sprunggelenkarthrose ; Histologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Meloxicam, einem neuen nichtsteroidalen Antiphlogistikum, auf die spontane Arthrose der Sprunggelenke von Crl:CDBR-Ratten wurde untersucht. Das Medikament war in einer Dosierung von 0,4, 0,6 und 0,8 mg/kg/Tag über einen Zeitraum von 2 Jahren 50 männlichen und 50 weiblichen Ratten (pro Dosis) mit dem Futter appliziert worden. 100 männliche und 100 weibliche unbehandelte Tiere dienten als Kontrollkollektiv. Histologisch wurden unterschiedliche arthrotische Veränderungen in Hüft-, Knie- und Sprunggelenken bei behandelten und unbehandelten Tieren beobachtet. Am häufigsten traten schwere Gelenkveränderungen in den Sprunggelenken auf. Wesentliche strukturelle Unterschiede zwischen behandelten und unbehandelten Tieren konnten histologisch nicht nachgewiesen werden. Es wird geschlossen, daß Meloxicam in der angewandten Dosierung keinen wesentlichen Einfluß auf die Sprunggelenkarthrose der Ratten ausübt und damit für diese Spezies als chondroneutral zu betrachten ist.
    Notes: Summary The effect of meloxicam, a new non-steroidal anti-inflammatory drug, on spontaneous osteoarthrosis of the ankle joint in Crl:CDBR rats was investigated. The drug was administered in the feed at doses of 0.4, 0.6 and 0.8 mg/kg/day over a period of 2 years to 50 males and 50 females per dose. 100 male rats and 100 female rats were used as controls. Histological examination revealed osteoarthrotic changes of varying degrees of severity in the hip, knee and ankle joints of both treated and untreated animals. The incidence and severity of these changes was greatest in the ankle joints. There was little difference between treated and untreated animals as regards the site, incidence, severity and histological appearance of the osteoarthrotic changes. At the doses tested, meloxicam does not affect the processes involved in spontaneous osteoarthrosis in the rat and can therefore be regarded as chondroneutral in this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050017
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  • 4
    Electronic Resource
    Electronic Resource
    Meloxicam: A potent inhibitor of adjuvant arthritis in the Lewis rat (1995)
    Springer
    Inflammation research 44 (1995), S. 548-555 
    Details
    ISSN: 1420-908X
    Keywords: Meloxicam ; Piroxicam ; Diclofenac ; Adjuvant arthritis ; Lewis rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of meloxicam, piroxicam, diclofenac and tenidap on the swelling of hind paws, radiologically-detectable bone and cartilage destruction of hind paws, increase in spleen weight, increase in erythrocyte sedimentation rate and changes in serum protein composition in male Lewis rats with adjuvant arthritis were studied following once-daily oral administration of these drugs for 21 days. All the drugs dose-dependently inhibited hind paw swelling. For equal activity against hind paw swelling caused by the secondary reaction, the required daily dose of piroxicam was about twice that of meloxicam; those of diclofenac and tenidap were about 3.5 and 60 times higher respectively. The bone and cartilage destruction induced by adjuvant arthritis were inhibited by meloxicam at low daily doses and by piroxicam at doses approximately four times those of meloxicam. Diclofenac and tenidap had only a weak effect on radiologically-detectable lesions when administered at doses sufficient to reduce paw swelling. Meloxicam also had a dose-dependent corrective effect on the systemic changes which occur in adjuvant arthritic rats, e.g. increase in spleen weight, increase in erythrocyte sedimentation rate and changes in serum protein composition. Piroxicam produced similar effects, at 3–4 times higher doses. Diclofenac and tenidap did not show comparable effects when administered at appropriate doses. These findings indicate that the action of meloxicam and piroxicam differs from that of diclofenac and tenidap in adjuvant arthritis in the Lewis rat. At oral doses which significantly reduce edema formation, only meloxicam and piroxicam showed a significant effect on systemic parameters of adjuvant disease in the Lewis rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01757360
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  • 5
    Electronic Resource
    Electronic Resource
    Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4′-isomer (1998)
    Springer
    Inflammation research 47 (1998), S. 270-276 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Cyclooxygenase — COX-1 — COX-2 — Non-steroidal anti-inflammatory drugs (NSAIDs)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: Two structurally related compounds, meloxicam (Mel) and its structural 4′-isomer (4′-Mel), were compared to examine the role of a slightly different chemical structure on cyclooxygenase (COX) selectivity in in vitro and in vivo experimental models.¶Material or Subjects: In vitro studies were performed using human whole blood obtained from healthy volunteers, in vivo studies were performed in rats.¶Treatment: A concentration-response curve was obtained in the whole blood assay for Mel, 4′-Mel, indomethacin, piroxicam and diclofenac. These were used to calculate the respective IC50 values of either prostaglandin E2 (PGE2) or thromboxane B2 (TxB2). Similarly, a dose-response curve was obtained for Mel, 4′-Mel and piroxicam when measuring in vivo prostaglandin production, anti-inflammatory activity and gastric tolerance to determine the dose resulting in a 50% reduction of the each parameter.¶Methods: COX selectivity was investigated in vitro using a human whole blood assay. PGE2 synthesis in vivo was measured in inflammatory exudate, in the stomach and kidneys of rats. Anti-inflammatory effects were measured in an adjuvant arthritis model and gastric tolerance was tested in an ulcerogenicity model in vivo in rats.¶Results: In the human whole blood assay, the ratio of IC50 values for COX-1 vs. COX-2 inhibition was 13 for Mel and 1.8 for 4′-Mel. In inflammatory exudate in rats, Mel and 4′-Mel inhibited PGE2 synthesis to a similar extent, ID50 values ∼ 0.3 mg/kg. In contrast, Mel was a weaker inhibitor of PG synthesis than 4′-Mel in the rat stomach and in the rat kidney. Paw swelling was reduced by 50% with 0.1 and 0.2 mg/kg for Mel and 4′-Mel, respectively, in the rat adjuvant arthritis model. Gastric tolerance (UD50) was 2.4 mg/kg for Mel and 0.4 mg/kg for 4′-Mel.¶Conclusions: These data demonstrate that the in vitro and in vivo pharmacological profile of meloxicam is structurally dependent and that minor structural changes can lead to significant differences in the selectivity for COX-1 and COX-2 in vitro and to different profiles in vivo suggesting different therapeutic potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050329
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  • 6
    Electronic Resource
    Electronic Resource
    Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance (1995)
    Springer
    Inflammation research 44 (1995), S. 423-433 
    Details
    ISSN: 1420-908X
    Keywords: Meloxicam ; Non-steroid anti-inflammatory drugs ; Anti-inflammatory activity ; Analgesic activity ; Gastrointestinal tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The anti-inflammatory, analgesic and antipyretic properties of the new non-steroidal anti-inflammatory agent, meloxicam, were investigated in a variety of animal models and compared with the properties of piroxicam, diclofenac, indomethacin and several other NSAIDs. With respect to the total effect of a single oral dose, the anti-exudative effect of meloxicam on carrageenaninduced oedema in the rat exceeded that of all the NSAIDs included in the comparison. Additionally, meloxicam showed the greatest potency of all the compounds examined with respect to adjuvant-induced arthritis in the rat, the granuloma pouch model and the cotton pellet test in the rat. Unlike indomethacin, in the carrageenan pleurisy model in the rat, meloxicam caused both a dose-dependent reduction in exudate volume and also inhibition of leucocyte migration. Meloxicam showed a strong and lasting effect on inflammatory pain in the rat. Like other NSAIDs, but unlike dipyrone, meloxicam had no effect in the hot plate and tail clamp tests, which are used to identify weak central analgesic effects. Unlike dipyrone and like indomethacin, meloxicam had no effect in a model of visceral distention pain. In common with other NSAIDs, meloxicam had no influence on the body temperature of normothermic rats in the anti-inflammatory dose range, but did reduce yeastinduced fever in the rat in a dose-dependent manner. Like piroxicam, meloxicam had a uricosuric effect on rats treated with oxonic acid. Low-dose meloxicam inhibited both bradykinin-induced and PAF-induced bronchospasm in the guinea-pig, but had no effect on acetylcholine-induced bronchospasm. Piroxicam had greater ulcerogenic effects in the rat stomach than meloxicam. The therapeutic range of meloxicam in the rat, with regard to inhibition of adjuvant arthritis, was several times greater than that of piroxicam, indomethacin, diclofenac and naproxen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01757699
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  • 7
    Electronic Resource
    Electronic Resource
    Bacterial metabolism of substituted phenols (1977)
    Springer
    Archives of microbiology 114 (1977), S. 25-33 
    Details
    ISSN: 1432-072X
    Keywords: Substituted phenols ; Insecticides ; “Meta”fission ; Nocardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 4-(Methylmercapto)-phenol (MMP) and 4-(methylsulfinyl)-phenol (MSP) are oxidized by the soil isolate Nocardia spec. DSM 43251, which is closely related to Nocardia calcarea. The rate of degradation depends on the capability of a substrate to support growth and is strongly enhanced in the presence of a second carbon source under the conditions of cooxidation. MMP and MSP are cometabolized by hydroxylation of the benzene ring with the formation of the substituted catechol following by ring cleavage between carbon atoms 2 and 3 (“meta”fission) to give 2-hydroxy-5-methylmercapto-or 2-hydroxy-5-methylsulfinylmuconic semialdehyde. Oxidation of MMP to MSP represents a bypath of MMP-oxidation. The intermediates were identified on the basis of their physical properties. The enzymes responsible for the metabolism of MMP and MSP are induced by growth with MMP or MSP, but not with glucose. MMP- and MSP-induced cells catalyze the oxidation of a variety of substituted phenols. This indicates a rather low substrate specificity of the enzymes induced by MMP and MSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429626
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  • 8
    Electronic Resource
    Electronic Resource
    Anwendung von29Si-KMR zur Analyse der silylierten Verbindungen. KMR-Spektren von (CH3)3Si-O-C-Derivaten (1978)
    Springer
    Colloid & polymer science 256 (1978), S. 624-624 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01639398
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  • 9
    Electronic Resource
    Electronic Resource
    The microbial metabolism of Di-n-Butyl phthalate and related dialkyl phthalates (1975)
    Springer
    Bulletin of environmental contamination and toxicology 13 (1975), S. 342-347 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01685348
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  • 10
    Electronic Resource
    Electronic Resource
    29Si NMR spectroscopy of cyclosiloxanes (1977)
    Springer
    Journal of structural chemistry 18 (1977), S. 463-470 
    Details
    ISSN: 1573-8779
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00753093
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